2YDV

Thermostabilised HUMAN A2a Receptor with NECA bound

Summary for 2YDV

Related1UPE 1MMH 2YDO
DescriptorADENOSINE RECEPTOR A2A, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL, ... (4 entities in total)
Functional Keywordsreceptor, g protein coupled receptor, seven-helix receptor, agonist bound form, thermostabilising point mutations, gpcr, 7tm receptor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane; Multi-pass membrane protein P29274
Total number of polymer chains1
Total molecular weight37873.24
Authors
Lebon, G.,Warne, T.,Edwards, P.C.,Bennett, K.,Langmead, C.J.,Leslie, A.G.W.,Tate, C.G. (deposition date: 2011-03-24, release date: 2011-05-18, Last modification date: 2011-07-13)
Primary citation
Lebon, G.,Warne, T.,Edwards, P.C.,Bennett, K.,Langmead, C.J.,Leslie, A.G.W.,Tate, C.G.
Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474:521-, 2011
PubMed: 21593763 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE10136
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers500.4%5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2ydv
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Molmil generated image of 2ydv
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Molmil generated image of 2ydv
rotated about y axis by 90°
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