2YDV
Thermostabilised HUMAN A2a Receptor with NECA bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADENOSINE RECEPTOR A2A | polymer | 325 | 36022.8 | 1 | UniProt (P29274) Pfam (PF00001) | HOMO SAPIENS (HUMAN) | THERMOSTABILISED HUMAN A2A RECEPTOR |
| 2 | B (A) | N-ETHYL-5'-CARBOXAMIDO ADENOSINE | non-polymer | 308.3 | 1 | Chemie (NEC) | |||
| 3 | C, D, E, F, G (A) | octyl 1-thio-beta-D-glucopyranoside | non-polymer | 308.4 | 5 | Chemie (SOG) | |||
| 4 | H (A) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 1 - 317 (UniProt: P29274)
| PDB | External Database | Details |
|---|---|---|
| Ala 48 | Leu 48 | engineered mutation |
| Leu 54 | Ala 54 | engineered mutation |
| Ala 65 | Thr 65 | engineered mutation |
| Ala 89 | Gln 89 | engineered mutation |
| Ala 154 | Asn 154 | engineered mutation |
| Ala 318 | - | expression tag |
| Ala 319 | - | expression tag |
| Glu 320 | - | expression tag |
| Asn 321 | - | expression tag |
| Leu 322 | - | expression tag |
| Tyr 323 | - | expression tag |
| Phe 324 | - | expression tag |
| Gln 325 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36022.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1850.5 | |
| All* | Total formula weight | 37873.2 |
