4ZJ8
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STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS
Descriptor:human OX1R fusion protein to P.abysii glycogen synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID
Authors:Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P., Renger, J.J., Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
4ZJC
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STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS
Descriptor:human OX1R fusion protein to P.abysii glycogen synthase, [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, OLEIC ACID
Authors:Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P.J., Renger, J.J., Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.832 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
5DYS
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CRYSTAL STRUCTURE OF T94I RHODOPSIN MUTANT
Descriptor:Rhodopsin, RETINAL, ACETATE ION, ...
Authors:Singhal, A., Guo, Y., Matkovic, M., Schertler, G., Deupi, X., Yan, E., Standfuss, J.
Deposit date:2015-09-25
Release date:2016-08-10
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.
Embo Rep., 17, 2016
5EN0
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CRYSTAL STRUCTURE OF T94I RHODOPSIN MUTANT
Descriptor:Rhodopsin, Guanine nucleotide-binding protein G(t) subunit alpha-3, RETINAL, ...
Authors:Singhal, A., Guo, Y., Matkovic, M., Schertler, G., Deupi, X., Yan, E., Standfuss, J.
Deposit date:2015-11-08
Release date:2016-08-10
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.
Embo Rep., 17, 2016
5KW2
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THE EXTRA-HELICAL BINDING SITE OF GPR40 AND THE STRUCTURAL BASIS FOR ALLOSTERIC AGONISM AND INCRETIN STIMULATION
Descriptor:Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1, (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid
Authors:Ho, J.D., Chau, B., Rodgers, L., Lu, F., Wilbur, K.L., Otto, K.A., Chen, Y., Song, M., Riley, J.P., Yang, H.-C., Reynolds, N.A., Kahl, S.D., Lewis, A.P., Groshong, C., Madsen, R.E., Conners, K., Linswala, J.P., Gheyi, T., Saflor, M.D., Lee, M.R., Benach, J., Baker, K.A., Montrose-Rafizadeh, C., Genin, M.J., Miller, A.R., Hamdouchi, C.
Deposit date:2016-07-15
Release date:2018-05-02
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural basis for GPR40 allosteric agonism and incretin stimulation.
Nat Commun, 9, 2018
5TE3
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CRYSTAL STRUCTURE OF BOS TAURUS OPSIN AT 2.7 ANGSTROM
Descriptor:Rhodopsin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Gulati, S., Kiser, P.D., Palczewski, K.
Deposit date:2016-09-20
Release date:2017-03-15
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TE5
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CRYSTAL STRUCTURE OF BOS TAURUS OPSIN REGENERATED WITH 6-CARBON RING RETINAL CHROMOPHORE
Descriptor:Rhodopsin, (2E)-{(4E)-4-[(3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-ylidene]cyclohex-2-en-1-ylidene}acetaldehyde
Authors:Gulati, S., Banerjee, S., Katayama, K., Kiser, P.D., Palczewski, K.
Deposit date:2016-09-20
Release date:2017-03-15
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (4.01 Å)
Cite:Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TZR
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GPR40 IN COMPLEX WITH PARTIAL AGONIST MK-8666
Descriptor:Free fatty acid receptor 1,Endolysin,Free fatty acid receptor 1, SODIUM ION, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ...
Authors:Lu, J., Byrne, N., Patel, S., Sharma, S., Soisson, S.M.
Deposit date:2016-11-22
Release date:2017-06-07
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
5TZY
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GPR40 IN COMPLEX WITH AGOPAM AP8 AND PARTIAL AGONIST MK-8666
Descriptor:Free fatty acid receptor 1,Endolysin,Free fatty acid receptor 1, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ...
Authors:Lu, J., Byrne, N., Patel, S., Sharma, S., Soisson, S.M.
Deposit date:2016-11-22
Release date:2017-06-07
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
5U09
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN CB1 CANNABINOID RECEPTOR
Descriptor:Cannabinoid receptor 1,GlgA glycogen synthase, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Shao, Z.H., Yin, J., Rosenbaum, D.
Deposit date:2016-11-23
Release date:2016-12-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:High-resolution crystal structure of the human CB1 cannabinoid receptor.
Nature, 2016
5WKT
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3.2-ANGSTROM IN SITU MYLAR STRUCTURE OF BOVINE OPSIN AT 100 K
Descriptor:Rhodopsin, Transducin Galpha peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broecker, J., Morizumi, T., Ou, W.-L., Ernst, O.P.
Deposit date:2017-07-25
Release date:2017-12-13
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.
Nat Protoc, 13, 2018
5WQC
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CRYSTAL STRUCTURE OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY THE SYNCHROTRON LIGHT SOURCE AT SPRING-8.
Descriptor:Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ...
Authors:Suno, R., Hirata, K., Yamashita, K., Tsujimoto, H., Sasanuma, M., Horita, S., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T.
Deposit date:2016-11-25
Release date:2017-11-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA
Structure, 26, 2018
5WS3
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CRYSTAL STRUCTURES OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT SACLA
Descriptor:Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ...
Authors:Suno, R., Kimura, K., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Tsujimoto, H., Sasanuma, M., Horita, S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T.
Deposit date:2016-12-05
Release date:2017-12-13
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Structure, 26, 2018
6E59
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CRYSTAL STRUCTURE OF THE HUMAN NK1 TACHYKININ RECEPTOR
Descriptor:Substance-P receptor, GlgA glycogen synthase, Substance-P receptor chimera, ...
Authors:Yin, J., Clark, L., Chapman, K., Shao, Z., Borek, D., Xu, Q., Wang, J., Rosenbaum, D.M.
Deposit date:2018-07-19
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the human NK1tachykinin receptor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FK6
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS01
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FK7
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS06
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FK8
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS08
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FK9
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS09
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FKA
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS11
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FKB
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS13
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FKC
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS15
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FKD
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS16
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FUF
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CRYSTAL STRUCTURE OF THE RHODOPSIN-MINI-GO COMPLEX
Descriptor:Rhodopsin, Guanine nucleotide-binding protein G(o) subunit alpha, RETINAL, ...
Authors:Tsai, C.-J., Weinert, T., Muehle, J., Pamula, F., Nehme, R., Flock, T., Nogly, P., Edwards, P.C., Carpenter, B., Gruhl, T., Ma, P., Deupi, X., Standfuss, J., Tate, C.G., Schertler, G.F.X.
Deposit date:2018-02-27
Release date:2018-10-03
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (3.117 Å)
Cite:Crystal structure of rhodopsin in complex with a mini-Gosheds light on the principles of G protein selectivity.
Sci Adv, 4, 2018
6H7J
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY NB80
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7L
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
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