4ZJ8 | | STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS | | Descriptor: | human OX1R fusion protein to P.abysii glycogen synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID | | Authors: | Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P., Renger, J.J., Rosenbaum, D.M. | | Deposit date: | 2015-04-29 | | Release date: | 2016-03-09 | | Last modified: | 2016-04-13 | | Method: | X-RAY DIFFRACTION (2.751 Å) | | Cite: | Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
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4ZJC | | STRUCTURES OF THE HUMAN OX1 OREXIN RECEPTOR BOUND TO SELECTIVE AND DUAL ANTAGONISTS | | Descriptor: | human OX1R fusion protein to P.abysii glycogen synthase, [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, OLEIC ACID | | Authors: | Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P.J., Renger, J.J., Rosenbaum, D.M. | | Deposit date: | 2015-04-29 | | Release date: | 2016-03-09 | | Last modified: | 2016-04-13 | | Method: | X-RAY DIFFRACTION (2.832 Å) | | Cite: | Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
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5DYS | | CRYSTAL STRUCTURE OF T94I RHODOPSIN MUTANT | | Descriptor: | Rhodopsin, RETINAL, ACETATE ION, ... | | Authors: | Singhal, A., Guo, Y., Matkovic, M., Schertler, G., Deupi, X., Yan, E., Standfuss, J. | | Deposit date: | 2015-09-25 | | Release date: | 2016-08-10 | | Last modified: | 2016-10-19 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.
Embo Rep., 17, 2016
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5EN0 | | CRYSTAL STRUCTURE OF T94I RHODOPSIN MUTANT | | Descriptor: | Rhodopsin, Guanine nucleotide-binding protein G(t) subunit alpha-3, RETINAL, ... | | Authors: | Singhal, A., Guo, Y., Matkovic, M., Schertler, G., Deupi, X., Yan, E., Standfuss, J. | | Deposit date: | 2015-11-08 | | Release date: | 2016-08-10 | | Last modified: | 2016-10-19 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.
Embo Rep., 17, 2016
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5KW2 | | THE EXTRA-HELICAL BINDING SITE OF GPR40 AND THE STRUCTURAL BASIS FOR ALLOSTERIC AGONISM AND INCRETIN STIMULATION | | Descriptor: | Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1, (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid | | Authors: | Ho, J.D., Chau, B., Rodgers, L., Lu, F., Wilbur, K.L., Otto, K.A., Chen, Y., Song, M., Riley, J.P., Yang, H.-C., Reynolds, N.A., Kahl, S.D., Lewis, A.P., Groshong, C., Madsen, R.E., Conners, K., Linswala, J.P., Gheyi, T., Saflor, M.D., Lee, M.R., Benach, J., Baker, K.A., Montrose-Rafizadeh, C., Genin, M.J., Miller, A.R., Hamdouchi, C. | | Deposit date: | 2016-07-15 | | Release date: | 2018-05-02 | | Last modified: | 2018-05-09 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structural basis for GPR40 allosteric agonism and incretin stimulation.
Nat Commun, 9, 2018
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5TE3 | | CRYSTAL STRUCTURE OF BOS TAURUS OPSIN AT 2.7 ANGSTROM | | Descriptor: | Rhodopsin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... | | Authors: | Gulati, S., Kiser, P.D., Palczewski, K. | | Deposit date: | 2016-09-20 | | Release date: | 2017-03-15 | | Last modified: | 2017-04-05 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TE5 | | CRYSTAL STRUCTURE OF BOS TAURUS OPSIN REGENERATED WITH 6-CARBON RING RETINAL CHROMOPHORE | | Descriptor: | Rhodopsin, (2E)-{(4E)-4-[(3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-ylidene]cyclohex-2-en-1-ylidene}acetaldehyde | | Authors: | Gulati, S., Banerjee, S., Katayama, K., Kiser, P.D., Palczewski, K. | | Deposit date: | 2016-09-20 | | Release date: | 2017-03-15 | | Last modified: | 2017-04-05 | | Method: | X-RAY DIFFRACTION (4.01 Å) | | Cite: | Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TZR | | GPR40 IN COMPLEX WITH PARTIAL AGONIST MK-8666 | | Descriptor: | Free fatty acid receptor 1,Endolysin,Free fatty acid receptor 1, SODIUM ION, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ... | | Authors: | Lu, J., Byrne, N., Patel, S., Sharma, S., Soisson, S.M. | | Deposit date: | 2016-11-22 | | Release date: | 2017-06-07 | | Last modified: | 2017-07-19 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
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5TZY | | GPR40 IN COMPLEX WITH AGOPAM AP8 AND PARTIAL AGONIST MK-8666 | | Descriptor: | Free fatty acid receptor 1,Endolysin,Free fatty acid receptor 1, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ... | | Authors: | Lu, J., Byrne, N., Patel, S., Sharma, S., Soisson, S.M. | | Deposit date: | 2016-11-22 | | Release date: | 2017-06-07 | | Last modified: | 2017-07-19 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
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5U09 | | HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN CB1 CANNABINOID RECEPTOR | | Descriptor: | Cannabinoid receptor 1,GlgA glycogen synthase, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | | Authors: | Shao, Z.H., Yin, J., Rosenbaum, D. | | Deposit date: | 2016-11-23 | | Release date: | 2016-12-07 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | High-resolution crystal structure of the human CB1 cannabinoid receptor.
Nature, 2016
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5WKT | | 3.2-ANGSTROM IN SITU MYLAR STRUCTURE OF BOVINE OPSIN AT 100 K | | Descriptor: | Rhodopsin, Transducin Galpha peptide, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Broecker, J., Morizumi, T., Ou, W.-L., Ernst, O.P. | | Deposit date: | 2017-07-25 | | Release date: | 2017-12-13 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.
Nat Protoc, 13, 2018
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5WQC | | CRYSTAL STRUCTURE OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY THE SYNCHROTRON LIGHT SOURCE AT SPRING-8. | | Descriptor: | Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ... | | Authors: | Suno, R., Hirata, K., Yamashita, K., Tsujimoto, H., Sasanuma, M., Horita, S., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T. | | Deposit date: | 2016-11-25 | | Release date: | 2017-11-29 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA
Structure, 26, 2018
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5WS3 | | CRYSTAL STRUCTURES OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT SACLA | | Descriptor: | Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ... | | Authors: | Suno, R., Kimura, K., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Tsujimoto, H., Sasanuma, M., Horita, S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T. | | Deposit date: | 2016-12-05 | | Release date: | 2017-12-13 | | Last modified: | 2018-06-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Structure, 26, 2018
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6E59 | | CRYSTAL STRUCTURE OF THE HUMAN NK1 TACHYKININ RECEPTOR | | Descriptor: | Substance-P receptor, GlgA glycogen synthase, Substance-P receptor chimera, ... | | Authors: | Yin, J., Clark, L., Chapman, K., Shao, Z., Borek, D., Xu, Q., Wang, J., Rosenbaum, D.M. | | Deposit date: | 2018-07-19 | | Release date: | 2018-12-12 | | Last modified: | 2019-01-09 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Crystal structure of the human NK1tachykinin receptor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FK6 | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS01 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FK7 | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS06 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FK8 | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS08 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FK9 | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS09 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FKA | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS11 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FKB | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS13 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (3.03 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FKC | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS15 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FKD | | CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS16 | | Descriptor: | Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Mattle, D., Standfuss, J., Dawson, R. | | Deposit date: | 2018-01-23 | | Release date: | 2018-04-04 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FUF | | CRYSTAL STRUCTURE OF THE RHODOPSIN-MINI-GO COMPLEX | | Descriptor: | Rhodopsin, Guanine nucleotide-binding protein G(o) subunit alpha, RETINAL, ... | | Authors: | Tsai, C.-J., Weinert, T., Muehle, J., Pamula, F., Nehme, R., Flock, T., Nogly, P., Edwards, P.C., Carpenter, B., Gruhl, T., Ma, P., Deupi, X., Standfuss, J., Tate, C.G., Schertler, G.F.X. | | Deposit date: | 2018-02-27 | | Release date: | 2018-10-03 | | Last modified: | 2018-10-10 | | Method: | X-RAY DIFFRACTION (3.117 Å) | | Cite: | Crystal structure of rhodopsin in complex with a mini-Gosheds light on the principles of G protein selectivity.
Sci Adv, 4, 2018
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6H7J | | ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY NB80 | | Descriptor: | Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, ... | | Authors: | Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. | | Deposit date: | 2018-07-31 | | Release date: | 2018-10-17 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
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6H7L | | ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY NB6B9 | | Descriptor: | Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ... | | Authors: | Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G. | | Deposit date: | 2018-07-31 | | Release date: | 2018-10-17 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
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