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8RWX
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BU of 8rwx by Molmil
Steady state structure of the human adenosine A2A receptor bound to synthetic photoswitch 'StilSwitch3' determined by serial synchrotron crystallography
Descriptor: 1,3-diethyl-8-[(~{E})-2-(4-methoxy-3-oxidanyl-phenyl)ethenyl]-7-methyl-purine-2,6-dione, Adenosine receptor A2a,Soluble cytochrome b562, OLEIC ACID, ...
Authors:Glover, H, Bertrand, Q, Weinert, T.
Deposit date:2024-02-05
Release date:2025-01-08
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography.
Nat Commun, 15, 2024
8RW0
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BU of 8rw0 by Molmil
Crystal structure of the adenosine A2A receptor in complex with Istradefylline
Descriptor: 8-[(~{E})-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione, Adenosine receptor A2a,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Glover, H.
Deposit date:2024-02-02
Release date:2025-01-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography.
Nat Commun, 15, 2024
8RW7
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BU of 8rw7 by Molmil
Crystal structure of the adenosine A2A receptor in complex with the synthetic photoswitch 'StilSwitch1
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 8-[(~{E})-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7~{H}-purine-2,6-dione, ...
Authors:Glover, H, Standfuss, J.
Deposit date:2024-02-02
Release date:2025-01-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography.
Nat Commun, 15, 2024
8RVW
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BU of 8rvw by Molmil
Dark structure of the human adenosine A2A receptor bound to synthetic photoswitch "StilSwitch3" determined by serial synchrotron crystallography
Descriptor: 1,3-diethyl-8-[(~{E})-2-(4-methoxy-3-oxidanyl-phenyl)ethenyl]-7-methyl-purine-2,6-dione, Adenosine receptor A2a,Adenosine receptor A2a,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Glover, H, Bertrand, Q.
Deposit date:2024-02-02
Release date:2025-01-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography.
Nat Commun, 15, 2024
8RWH
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BU of 8rwh by Molmil
Dark structure of the human adenosine A2A receptor bound to synthetic photoswitch 'StilSwitch2' determined by serial synchrotron crystallography
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 8-[(~{E})-2-[3,4-bis(oxidanyl)phenyl]ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione, ...
Authors:Glover, H, Weinert, T.
Deposit date:2024-02-04
Release date:2025-01-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography.
Nat Commun, 15, 2024
7C4S
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BU of 7c4s by Molmil
Sphingosine-1-phosphate receptor 3 with a natural ligand.
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ...
Authors:Iwata, S, Maeda, S, Luo, F, Nango, E, hirata, K, Asada, H.
Deposit date:2020-05-18
Release date:2021-06-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.
Sci Adv, 7, 2021
7WC4
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BU of 7wc4 by Molmil
Crystal structure of serotonin 2A receptor in complex with serotonin
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7VV0
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BU of 7vv0 by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local
Descriptor: CHOLESTEROL, Mas-related G-protein coupled receptor member X2, peptide from Pro-adrenomedullin
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VV6
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BU of 7vv6 by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local)
Descriptor: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Mas-related G-protein coupled receptor member X2
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7WC5
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BU of 7wc5 by Molmil
Crystal structure of serotonin 2A receptor in complex with psilocin
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
8JPF
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BU of 8jpf by Molmil
Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, NTS, Neurotensin receptor type 1
Authors:Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E.
Deposit date:2023-06-11
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
8K5C
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BU of 8k5c by Molmil
Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 (Local refinement)
Descriptor: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Human hydroxycarboxylic acid receptor 2
Authors:Park, J.H, Ishimoto, N, Park, S.Y.
Deposit date:2023-07-21
Release date:2023-11-22
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun, 14, 2023
8K5B
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BU of 8k5b by Molmil
Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 (Local refinement)
Descriptor: Human Hydroxycarboxylic acid receptor 2, NICOTINIC ACID
Authors:Park, J.H, Ishimoto, N, Park, S.Y.
Deposit date:2023-07-21
Release date:2023-11-22
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun, 14, 2023
8K5D
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BU of 8k5d by Molmil
Cryo-EM structure of GSK256073 bound human hydroxy-carboxylic acid receptor 2 (Local refinement)
Descriptor: 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Human hydroxycarboxylic acid receptor 2
Authors:Park, J.H, Ishimoto, N, Park, S.Y.
Deposit date:2023-07-21
Release date:2023-11-22
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun, 14, 2023
8IWE
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BU of 8iwe by Molmil
Cryo-EM structure of the SPE-mTAAR9 complex
Descriptor: SPERMIDINE, Trace amine-associated receptor 9
Authors:Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K.
Deposit date:2023-03-29
Release date:2023-05-31
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of amine odorant perception by a mammal olfactory receptor.
Nature, 618, 2023
8IWM
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BU of 8iwm by Molmil
Cryo-EM structure of the PEA-bound mTAAR9 complex
Descriptor: 2-PHENYLETHYLAMINE, Trace amine-associated receptor 9
Authors:Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K.
Deposit date:2023-03-30
Release date:2023-05-31
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis of amine odorant perception by a mammal olfactory receptor.
Nature, 618, 2023
8KIG
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BU of 8kig by Molmil
Cryo-EM structure of MC3R in complex with SHU9119
Descriptor: CALCIUM ION, SHU9119, Soluble cytochrome b562,Melanocortin receptor 3,GlgA glycogen synthase,Fusion protein
Authors:Chen, Q, Fu, J.
Deposit date:2023-08-23
Release date:2025-02-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure basis of ligand selectivity and signal transduction in human melanocortin-3 receptor
To Be Published
8GNG
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BU of 8gng by Molmil
Crystal structure of human adenosine A2A receptor in complex with istradefylline.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 8-[(~{E})-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione, Adenosine receptor A2a, ...
Authors:Suzuki, M, Saito, J, Miyagi, H, Yasunaga, M.
Deposit date:2022-08-23
Release date:2023-03-22
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A 2A Receptor Antagonist/Inverse Agonist.
Mol.Pharmacol., 103, 2023
8GGI
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BU of 8ggi by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGJ
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BU of 8ggj by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGK
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BU of 8ggk by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #3 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGL
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BU of 8ggl by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #4 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGM
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BU of 8ggm by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGS
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BU of 8ggs by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #11 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGO
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BU of 8ggo by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024

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PDB entries from 2025-07-09

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