7C4S

Sphingosine-1-phosphate receptor 3 with a natural ligand.

Summary for 7C4S

• Entry DOI: 10.2210/pdb7c4s/pdb
• Descriptor: Antibody Fab fragment light chain, Antibody Fab fragment heavy chain, Sphingosine 1-phosphate receptor 3, ... (4 entities in total)
• Functional Keywords: g protein-coupled receptor, signaling protein, agonist, natural ligand, lysophospholipid, regulator of immune system and vascular integrity., membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 179359.97

Authors

Iwata, S.,Maeda, S.,Luo, F.,Nango, E.,hirata, K.,Asada, H. (deposition date: 2020-05-18, release date: 2021-06-09, Last modification date: 2023-11-29)

• Primary citation: Maeda, S.,Shiimura, Y.,Asada, H.,Hirata, K.,Luo, F.,Nango, E.,Tanaka, N.,Toyomoto, M.,Inoue, A.,Aoki, J.,Iwata, S.,Hagiwara, M.; Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.; Sci Adv, 7:-, 2021; PubMed: 34108205; DOI: 10.1126/sciadv.abf5325

Experimental method

X-RAY DIFFRACTION (3.2 Å)