8GNG
Crystal structure of human adenosine A2A receptor in complex with istradefylline.
Summary for 8GNG
| Entry DOI | 10.2210/pdb8gng/pdb |
| Related | 8GNE |
| Descriptor | Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain, ... (8 entities in total) |
| Functional Keywords | adenosine a2a receptor, istradefylline, neutral antagonist, membrane protein, membrane protein-immune system complex, membrane protein/immune system |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 174796.92 |
| Authors | Suzuki, M.,Saito, J.,Miyagi, H.,Yasunaga, M. (deposition date: 2022-08-23, release date: 2023-03-22, Last modification date: 2023-11-29) |
| Primary citation | Ohno, Y.,Suzuki, M.,Asada, H.,Kanda, T.,Saki, M.,Miyagi, H.,Yasunaga, M.,Suno, C.,Iwata, S.,Saito, J.I.,Uchida, S. In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A 2A Receptor Antagonist/Inverse Agonist. Mol.Pharmacol., 103:311-324, 2023 Cited by PubMed: 36894319DOI: 10.1124/molpharm.122.000633 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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