8GNE

Crystal structure of human adenosine A2A receptor in complex with an insurmountable inverse agonist, KW-6356.

Summary for 8GNE

Entry DOI	10.2210/pdb8gne/pdb
Descriptor	Adenosine receptor A2a,Soluble cytochrome b562, ~{N}-[4-(furan-2-yl)-5-(oxan-4-ylcarbonyl)-1,3-thiazol-2-yl]-6-methyl-pyridine-3-carboxamide, CHOLESTEROL, ... (7 entities in total)
Functional Keywords	adenosine a2a receptor, inverse agonist, insurmountable antagonism, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	56524.57
Authors	Suzuki, M.,Saito, J.,Miyagi, H.,Yasunaga, M. (deposition date: 2022-08-23, release date: 2023-03-22, Last modification date: 2023-11-29)
Primary citation	Ohno, Y.,Suzuki, M.,Asada, H.,Kanda, T.,Saki, M.,Miyagi, H.,Yasunaga, M.,Suno, C.,Iwata, S.,Saito, J.I.,Uchida, S. In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A 2A Receptor Antagonist/Inverse Agonist. Mol.Pharmacol., 103:311-324, 2023 Cited by PubMed: 36894319 DOI: 10.1124/molpharm.122.000633 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation