8BTK
| Structure of the TRAP complex with the Sec translocon and a translating ribosome | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Jaskolowski, M, Jomaa, A, Gamerdinger, M, Shrestha, S, Leibundgut, M, Deuerling, E, Ban, N. | Deposit date: | 2022-11-29 | Release date: | 2023-05-24 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of the TRAP complex function in ER protein biogenesis. Nat.Struct.Mol.Biol., 30, 2023
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8BHF
| Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4 | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S11, ... | Authors: | Absmeier, E, Chandrasekaran, V, O'Reilly, F.J, Stowell, J.A.W, Rappsilber, J, Passmore, L.A. | Deposit date: | 2022-10-31 | Release date: | 2023-09-06 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
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7TOR
| Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | Deposit date: | 2022-01-24 | Release date: | 2022-05-25 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TOQ
| Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | Deposit date: | 2022-01-24 | Release date: | 2022-05-25 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TM3
| Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | Deposit date: | 2022-01-19 | Release date: | 2022-10-19 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
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7UCK
| 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | Deposit date: | 2022-03-16 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022
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7UCJ
| Mammalian 80S translation initiation complex with mRNA and Harringtonine | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | Deposit date: | 2022-03-16 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022
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7TUT
| Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | Deposit date: | 2022-02-03 | Release date: | 2022-10-19 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
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6R6P
| Structure of XBP1u-paused ribosome nascent chain complex (rotated state) | Descriptor: | 18S rRNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2019-03-27 | Release date: | 2019-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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6QZP
| High-resolution cryo-EM structure of the human 80S ribosome | Descriptor: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ... | Authors: | Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P. | Deposit date: | 2019-03-12 | Release date: | 2019-04-24 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Visualization of chemical modifications in the human 80S ribosome structure. Nature, 551, 2017
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6R6G
| Structure of XBP1u-paused ribosome nascent chain complex with SRP. | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. | Deposit date: | 2019-03-27 | Release date: | 2019-07-10 | Last modified: | 2019-10-30 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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6R7Q
| Structure of XBP1u-paused ribosome nascent chain complex with Sec61. | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. | Deposit date: | 2019-03-29 | Release date: | 2019-07-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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6R5Q
| Structure of XBP1u-paused ribosome nascent chain complex (post-state) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2019-03-25 | Release date: | 2019-07-10 | Last modified: | 2019-10-30 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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6SGC
| Rabbit 80S ribosome stalled on a poly(A) tail | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Chandrasekaran, V, Juszkiewicz, S, Choi, J, Puglisi, J.D, Brown, A, Shao, S, Ramakrishnan, V, Hegde, R.S. | Deposit date: | 2019-08-03 | Release date: | 2019-12-04 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of ribosome stalling during translation of a poly(A) tail. Nat.Struct.Mol.Biol., 26, 2019
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6SWA
| Mus musculus brain neocortex ribosome 60S bound to Ebp1 | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kraushar, M.L, Sprink, T. | Deposit date: | 2019-09-20 | Release date: | 2020-09-30 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit. Mol.Cell, 81, 2021
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6T59
| Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 and nascent chain-associated complex | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Lin, Z, Gasic, I, Chandrasekaran, V, Peters, N, Shao, S, Ramakrishnan, V, Mitchison, T.J, Hegde, R.S. | Deposit date: | 2019-10-15 | Release date: | 2019-11-27 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | TTC5 mediates autoregulation of tubulin via mRNA degradation. Science, 367, 2020
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3JBO
| Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... | Authors: | Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. | Deposit date: | 2015-09-16 | Release date: | 2015-10-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015
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3JCS
| 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania | Descriptor: | 26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S epsilon ribosomal RNA, ... | Authors: | Shalev-Benami, M, Zhang, Y, Matzov, D, Halfon, Y, Zackay, A, Rozenberg, H, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. | Deposit date: | 2016-01-21 | Release date: | 2016-07-20 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania. Cell Rep, 16, 2016
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3JAH
| Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. | Deposit date: | 2015-06-10 | Release date: | 2015-08-12 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis for stop codon recognition in eukaryotes. Nature, 524, 2015
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3JAG
| Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. | Deposit date: | 2015-06-10 | Release date: | 2015-08-12 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Structural basis for stop codon recognition in eukaryotes. Nature, 524, 2015
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3J79
| Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W. | Deposit date: | 2014-06-02 | Release date: | 2014-07-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. Elife, 3, 2014
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3JBP
| Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... | Authors: | Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. | Deposit date: | 2015-09-16 | Release date: | 2015-10-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015
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3JBN
| Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... | Authors: | Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. | Deposit date: | 2015-09-16 | Release date: | 2015-10-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015
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3JAI
| Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. | Deposit date: | 2015-06-10 | Release date: | 2015-08-12 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Structural basis for stop codon recognition in eukaryotes. Nature, 524, 2015
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5LKS
| Structure-function insights reveal the human ribosome as a cancer target for antibiotics | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P. | Deposit date: | 2016-07-23 | Release date: | 2017-04-26 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure-function insights reveal the human ribosome as a cancer target for antibiotics. Nat Commun, 7, 2016
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