3J79

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit

This is a large structure.

> Summary

Summary for 3J79

Related3J7A
Integrates1VX6 1VX7
EMDB informationEMD-2660 EMD-2661
DescriptorPROTEIN/RNA Complex
Functional Keywordsemetine, ribosome-inhibitor complex, ribosome/inhibitor
Biological sourcePlasmodium falciparum
Total number of polymer chains45
Total molecular weight2135897.1
Authors
Wong, W.,Bai, X.C.,Brown, A.,Fernandez, I.S.,Hanssen, E.,Condron, M.,Tan, Y.H.,Baum, J.,Scheres, S.H.W. (deposition date: 2014-06-02, release date: 2014-07-16, modification date: 2015-06-03)
Primary citation
Wong, W.,Bai, X.C.,Brown, A.,Fernandez, I.S.,Hanssen, E.,Condron, M.,Tan, Y.H.,Baum, J.,Scheres, S.H.
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3:e03080-e03080, 2014
PubMed: 24913268
DOI: 10.7554/eLife.03080
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone42.4%10.6%0.43MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 3j79
no rotation
Molmil generated image of 3j79
rotated about x axis by 90°
Molmil generated image of 3j79
rotated about y axis by 90°

> Structural details

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
A28S ribosomal RNApolymer37881216213.41
Plasmodium falciparum
B5S ribosomal RNApolymer11938411.11
Plasmodium falciparum
C5.8S ribosomal RNApolymer15951206.81
Plasmodium falciparum
D60S ribosomal protein uL2polymer26028065.21
UniProt (Q8I3T9)
Pfam (PF00181)
Pfam (PF03947)
Plasmodium falciparum
E60S ribosomal protein uL3polymer38644318.61
UniProt (Q8IJC6)
Pfam (PF00297)
Plasmodium falciparum
F60S ribosomal protein uL4polymer41146312.11
UniProt (Q8I431)
Pfam (PF00573)
Pfam (PF14374)
Plasmodium falciparum
G60S ribosomal protein uL5polymer17320268.81
UniProt (Q8IBQ6)
Pfam (PF00281)
Pfam (PF00673)
Plasmodium falciparum
H60S ribosomal protein uL6polymer19021638.71
UniProt (Q8IE85)
Pfam (PF00347)
Plasmodium falciparum
I60S ribosomal protein eL6polymer22125587.81
UniProt (Q8IDV1)
Pfam (PF01159)
Plasmodium falciparum
J60S ribosomal protein eL8polymer28332760.71
UniProt (Q8ILL2)
Pfam (PF01248)
Plasmodium falciparum
K60S ribosomal protein uL13polymer20223805.51
UniProt (Q8IJZ7)
Pfam (PF00572)
Plasmodium falciparum
L60S ribosomal protein eL13polymer21525508.41
UniProt (Q8IAX6)
Pfam (PF01294)
Plasmodium falciparum
M60S ribosomal protein uL14polymer13915015.81
UniProt (Q8IE09)
Pfam (PF00238)
Plasmodium falciparum
N60S ribosomal protein eL14polymer16519340.51
UniProt (Q8ILE8)
Pfam (PF01929)
Plasmodium falciparum
O60S ribosomal protein uL15polymer14816766.01
UniProt (C6KT23)
Pfam (PF00828)
Plasmodium falciparum
P60S ribosomal protein eL15polymer20524197.91
UniProt (C0H4A6)
Pfam (PF00827)
Plasmodium falciparum
Q60S ribosomal protein uL16polymer21925265.71
UniProt (Q8ILV2)
Pfam (PF00252)
Plasmodium falciparum
R60S ribosomal protein uL18polymer29434067.61
UniProt (Q8ILL3)
Pfam (PF14204)
Pfam (PF17144)
Plasmodium falciparum
S60S ribosomal protein eL18polymer18721509.01
UniProt (C0H5G3)
Pfam (PF17135)
Plasmodium falciparum
T60S ribosomal protein eL19polymer18221641.31
UniProt (C6KSY6)
Pfam (PF01280)
Plasmodium falciparum
U60S ribosomal protein eL20polymer18421793.81
UniProt (Q8IDS6)
Pfam (PF01775)
Plasmodium falciparum
V60S ribosomal protein eL21polymer16118840.41
UniProt (Q8ILK3)
Pfam (PF01157)
Plasmodium falciparum
W60S ribosomal protein uL22polymer20323470.11
UniProt (Q8IDI5)
Pfam (PF00237)
Plasmodium falciparum
X60S ribosomal protein eL22polymer13916423.11
UniProt (Q8IB51)
Pfam (PF01776)
Plasmodium falciparum
Y60S ribosomal protein uL23polymer19022152.91
UniProt (Q8IE82)
Pfam (PF00276)
Pfam (PF03939)
Plasmodium falciparum
Z60S ribosomal protein uL24polymer12614855.81
UniProt (O77364)
Pfam (PF00467)
Pfam (PF16906)
Plasmodium falciparum
060S ribosomal protein eL24polymer16219296.11
UniProt (Q8IEM3)
Pfam (PF01246)
Plasmodium falciparum
160S ribosomal protein eL27polymer14616785.31
UniProt (Q8IKM5)
Pfam (PF01777)
Plasmodium falciparum
260S ribosomal protein eL28polymer12714437.91
UniProt (Q8IHU0)
Pfam (PF01778)
Plasmodium falciparum
360S ribosomal protein uL29polymer12414788.01
UniProt (Q8IIB4)
Pfam (PF00831)
Plasmodium falciparum
460S ribosomal protein eL29polymer678041.71
UniProt (C6S3J6)
Pfam (PF01779)
Plasmodium falciparum
560S ribosomal protein uL30polymer25730593.41
UniProt (O97250)
Pfam (PF00327)
Pfam (PF08079)
Plasmodium falciparum
660S ribosomal protein eL30polymer10811794.81
UniProt (Q8IJK8)
Pfam (PF01248)
Plasmodium falciparum
760S ribosomal protein eL31polymer12014100.01
UniProt (Q8I463)
Pfam (PF01198)
Plasmodium falciparum
860S ribosomal protein eL32polymer13115565.91
UniProt (Q8I3B0)
Pfam (PF01655)
Plasmodium falciparum
960S ribosomal protein eL33polymer14016306.61
UniProt (Q8IHT9)
Pfam (PF01247)
Plasmodium falciparum
a60S ribosomal protein eL34polymer15017407.11
UniProt (Q8IBY4)
Pfam (PF01199)
Plasmodium falciparum
b60S ribosomal protein eL36polymer11212825.61
UniProt (Q8I713)
Pfam (PF01158)
Plasmodium falciparum
c60S ribosomal protein eL37polymer9210571.71
UniProt (C0H4L5)
Pfam (PF01907)
Plasmodium falciparum
d60S ribosomal protein eL38polymer8710341.81
UniProt (Q8II62)
Pfam (PF01781)
Plasmodium falciparum
e60S ribosomal protein eL39polymer516541.01
UniProt (C0H4H3)
Pfam (PF00832)
Plasmodium falciparum
f60S ribosomal protein eL40polymer12814645.31
UniProt (Q8ID50)
Pfam (PF00240)
Pfam (PF01020)
Plasmodium falciparum
g60S ribosomal protein eL41polymer395108.31
UniProt (C6S3G4)
Pfam (PF05162)
Plasmodium falciparum
h60S ribosomal protein eL43polymer9610826.21
UniProt (O96184)
Pfam (PF01780)
Plasmodium falciparum
i60S ribosomal protein eL44polymer10412195.01
UniProt (O97231)
Pfam (PF00935)
Plasmodium falciparum
MAGNESIUM IONnon-polymer24.3163
ZINC IONnon-polymer65.45

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains45
Total molecular weight2131608.5
Non-Polymers*Number of molecules168
Total molecular weight4288.6
All*Total molecular weight2135897.1
*Water molecules are not included.

> Experimental details

Refinement Statistics

Experimental method:ELECTRON MICROSCOPY

Cell axes1.0001.0001.000
Cell angles90.0090.0090.00
SpacegroupP 1
Resolution limits -
the highest resolution shell value -

Data Collection Statistics

Resolution limits -
the highest resolution shell value -

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
Annotated Information is extracted from Literature Info*

> Functional details

?

Functional Information from GO Data

ChainGOidnamespacecontents
h0005840cellular_componentribosome
h0046872molecular_functionmetal ion binding
h0003735molecular_functionstructural constituent of ribosome
h0006412biological_processtranslation
i0022625cellular_componentcytosolic large ribosomal subunit
i0003735molecular_functionstructural constituent of ribosome
i0006412biological_processtranslation
R0022625cellular_componentcytosolic large ribosomal subunit
R0008097molecular_function5S rRNA binding
R0003735molecular_functionstructural constituent of ribosome
R0000027biological_processribosomal large subunit assembly
R0006412biological_processtranslation
N0022627cellular_componentcytosolic small ribosomal subunit
N0003735molecular_functionstructural constituent of ribosome
N0006412biological_processtranslation
J0022625cellular_componentcytosolic large ribosomal subunit
J0003723molecular_functionRNA binding
J0003735molecular_functionstructural constituent of ribosome
J0000470biological_processmaturation of LSU-rRNA
J0006412biological_processtranslation
d0022625cellular_componentcytosolic large ribosomal subunit
d0003735molecular_functionstructural constituent of ribosome
d0006412biological_processtranslation
30022625cellular_componentcytosolic large ribosomal subunit
30015934cellular_componentlarge ribosomal subunit
30003729molecular_functionmRNA binding
30003735molecular_functionstructural constituent of ribosome
30000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
30006412biological_processtranslation
90015934cellular_componentlarge ribosomal subunit
90003735molecular_functionstructural constituent of ribosome
90006412biological_processtranslation
E0022625cellular_componentcytosolic large ribosomal subunit
E0003735molecular_functionstructural constituent of ribosome
E0006412biological_processtranslation
10022625cellular_componentcytosolic large ribosomal subunit
10003735molecular_functionstructural constituent of ribosome
10006412biological_processtranslation
40022625cellular_componentcytosolic large ribosomal subunit
40003735molecular_functionstructural constituent of ribosome
40002181biological_processcytoplasmic translation
V0022625cellular_componentcytosolic large ribosomal subunit
V0003735molecular_functionstructural constituent of ribosome
V0006412biological_processtranslation
Q0022625cellular_componentcytosolic large ribosomal subunit
Q0003735molecular_functionstructural constituent of ribosome
Q0000027biological_processribosomal large subunit assembly
Q0006412biological_processtranslation
b0022625cellular_componentcytosolic large ribosomal subunit
b0003735molecular_functionstructural constituent of ribosome
b0002181biological_processcytoplasmic translation
b0006412biological_processtranslation
g0005840cellular_componentribosome
g0003735molecular_functionstructural constituent of ribosome
g0006412biological_processtranslation
K0022625cellular_componentcytosolic large ribosomal subunit
K0003729molecular_functionmRNA binding
K0003735molecular_functionstructural constituent of ribosome
K0006412biological_processtranslation
20022625cellular_componentcytosolic large ribosomal subunit
20003735molecular_functionstructural constituent of ribosome
20006412biological_processtranslation
60022625cellular_componentcytosolic large ribosomal subunit
60003723molecular_functionRNA binding
60003735molecular_functionstructural constituent of ribosome
60006412biological_processtranslation
U0022625cellular_componentcytosolic large ribosomal subunit
U0003735molecular_functionstructural constituent of ribosome
U0006412biological_processtranslation
50022625cellular_componentcytosolic large ribosomal subunit
50003735molecular_functionstructural constituent of ribosome
50002181biological_processcytoplasmic translation
50000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
50006412biological_processtranslation
f0022625cellular_componentcytosolic large ribosomal subunit
f0031386molecular_functionprotein tag
f0003735molecular_functionstructural constituent of ribosome
f0006464biological_processcellular protein modification process
f0006412biological_processtranslation
f0006511biological_processubiquitin-dependent protein catabolic process
70022625cellular_componentcytosolic large ribosomal subunit
70003735molecular_functionstructural constituent of ribosome
70006412biological_processtranslation
L0022625cellular_componentcytosolic large ribosomal subunit
L0003723molecular_functionRNA binding
L0003735molecular_functionstructural constituent of ribosome
L0006412biological_processtranslation
S0022625cellular_componentcytosolic large ribosomal subunit
S0003735molecular_functionstructural constituent of ribosome
S0006412biological_processtranslation
Z0022625cellular_componentcytosolic large ribosomal subunit
Z0003735molecular_functionstructural constituent of ribosome
Z0006412biological_processtranslation
M0022625cellular_componentcytosolic large ribosomal subunit
M0070180molecular_functionlarge ribosomal subunit rRNA binding
M0003735molecular_functionstructural constituent of ribosome
M0006412biological_processtranslation
D0022625cellular_componentcytosolic large ribosomal subunit
D0003735molecular_functionstructural constituent of ribosome
D0002181biological_processcytoplasmic translation
D0006412biological_processtranslation
P0022625cellular_componentcytosolic large ribosomal subunit
P0005840cellular_componentribosome
P0003735molecular_functionstructural constituent of ribosome
P0002181biological_processcytoplasmic translation
P0006412biological_processtranslation
e0022625cellular_componentcytosolic large ribosomal subunit
e0003723molecular_functionRNA binding
e0003735molecular_functionstructural constituent of ribosome
e0006412biological_processtranslation
00022625cellular_componentcytosolic large ribosomal subunit
00003735molecular_functionstructural constituent of ribosome
01902626biological_processassembly of large subunit precursor of preribosome
00000027biological_processribosomal large subunit assembly
00006412biological_processtranslation
W0022625cellular_componentcytosolic large ribosomal subunit
W0003735molecular_functionstructural constituent of ribosome
W0006412biological_processtranslation
Y0022625cellular_componentcytosolic large ribosomal subunit
Y0000166molecular_functionnucleotide binding
Y0019843molecular_functionrRNA binding
Y0003735molecular_functionstructural constituent of ribosome
Y0000027biological_processribosomal large subunit assembly
Y0006412biological_processtranslation
80022625cellular_componentcytosolic large ribosomal subunit
80003735molecular_functionstructural constituent of ribosome
80006412biological_processtranslation
a0022625cellular_componentcytosolic large ribosomal subunit
a0003723molecular_functionRNA binding
a0003735molecular_functionstructural constituent of ribosome
a0042254biological_processribosome biogenesis
a0006412biological_processtranslation
c0022625cellular_componentcytosolic large ribosomal subunit
c0046872molecular_functionmetal ion binding
c0003723molecular_functionRNA binding
c0019843molecular_functionrRNA binding
c0003735molecular_functionstructural constituent of ribosome
c0006412biological_processtranslation
H0022625cellular_componentcytosolic large ribosomal subunit
H0015934cellular_componentlarge ribosomal subunit
H0003723molecular_functionRNA binding
H0019843molecular_functionrRNA binding
H0003735molecular_functionstructural constituent of ribosome
H0002181biological_processcytoplasmic translation
H0006412biological_processtranslation
G0022625cellular_componentcytosolic large ribosomal subunit
G0003735molecular_functionstructural constituent of ribosome
G0000027biological_processribosomal large subunit assembly
G0006412biological_processtranslation
O0022625cellular_componentcytosolic large ribosomal subunit
O0015934cellular_componentlarge ribosomal subunit
O0003735molecular_functionstructural constituent of ribosome
O0006412biological_processtranslation
T0022625cellular_componentcytosolic large ribosomal subunit
T0003735molecular_functionstructural constituent of ribosome
T0006412biological_processtranslation
F0022625cellular_componentcytosolic large ribosomal subunit
F0003735molecular_functionstructural constituent of ribosome
F0006412biological_processtranslation
I0022625cellular_componentcytosolic large ribosomal subunit
I0003735molecular_functionstructural constituent of ribosome
I0002181biological_processcytoplasmic translation
I0000027biological_processribosomal large subunit assembly
I0006412biological_processtranslation
X0022625cellular_componentcytosolic large ribosomal subunit
X0003735molecular_functionstructural constituent of ribosome
X0002181biological_processcytoplasmic translation
X0006412biological_processtranslation
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC11BINDING SITE FOR RESIDUE MG A 3801
ChainResidue
AG1592

AC23BINDING SITE FOR RESIDUE MG A 3802
ChainResidue
AA1584
AU1585
AC1586

AC31BINDING SITE FOR RESIDUE MG A 3803
ChainResidue
AG1589

AC42BINDING SITE FOR RESIDUE MG A 3804
ChainResidue
AC726
AG2669

AC51BINDING SITE FOR RESIDUE MG A 3805
ChainResidue
AA1271

AC65BINDING SITE FOR RESIDUE MG A 3806
ChainResidue
8ASP39
AU720
AA723
AG1270
AA1271

AC71BINDING SITE FOR RESIDUE MG A 3807
ChainResidue
AC1269

AC81BINDING SITE FOR RESIDUE MG A 3808
ChainResidue
AC923

AC92BINDING SITE FOR RESIDUE MG A 3809
ChainResidue
AC719
AU1061

BC12BINDING SITE FOR RESIDUE MG A 3810
ChainResidue
AC2955
AU2956

BC21BINDING SITE FOR RESIDUE MG A 3811
ChainResidue
AC1080

BC32BINDING SITE FOR RESIDUE MG A 3812
ChainResidue
AA40
AU2704

BC45BINDING SITE FOR RESIDUE MG A 3813
ChainResidue
AG41
AC42
AU2704
AG2705
AU2951

BC52BINDING SITE FOR RESIDUE MG A 3814
ChainResidue
AU2710
AG2945

BC63BINDING SITE FOR RESIDUE MG A 3815
ChainResidue
AU2709
AG2946
DPRO206

BC73BINDING SITE FOR RESIDUE MG A 3816
ChainResidue
AG1035
AG1043
AG3316

BC84BINDING SITE FOR RESIDUE MG A 3817
ChainResidue
AA1034
AG1035
AA3317
DASN205

BC91BINDING SITE FOR RESIDUE MG A 3818
ChainResidue
AC2425

CC11BINDING SITE FOR RESIDUE MG A 3819
ChainResidue
AC2439

CC21BINDING SITE FOR RESIDUE MG A 3820
ChainResidue
AA2481

CC31BINDING SITE FOR RESIDUE MG A 3821
ChainResidue
AA2606

CC42BINDING SITE FOR RESIDUE MG A 3822
ChainResidue
AG2478
AU2479

CC51BINDING SITE FOR RESIDUE MG A 3823
ChainResidue
AU749

CC61BINDING SITE FOR RESIDUE MG A 3824
ChainResidue
AA62

CC74BINDING SITE FOR RESIDUE MG A 3825
ChainResidue
AA1542
AG1543
AC1568
AA1569

CC82BINDING SITE FOR RESIDUE MG A 3826
ChainResidue
AG1069
AG1516

CC93BINDING SITE FOR RESIDUE MG A 3827
ChainResidue
AU1067
AA1515
AG1516

DC15BINDING SITE FOR RESIDUE MG A 3828
ChainResidue
AG3175
AA3176
AC3225
AC3226
AU3227

DC23BINDING SITE FOR RESIDUE MG A 3829
ChainResidue
AG3309
AG3310
AG3311

DC33BINDING SITE FOR RESIDUE MG A 3830
ChainResidue
AC2622
AA3278
AU3279

DC44BINDING SITE FOR RESIDUE MG A 3831
ChainResidue
AA2169
AG2170
AU2171
AA3278

DC51BINDING SITE FOR RESIDUE MG A 3832
ChainResidue
AA1729

DC62BINDING SITE FOR RESIDUE MG A 3833
ChainResidue
AC1681
AA1729

DC72BINDING SITE FOR RESIDUE MG A 3834
ChainResidue
AG1733
AG1735

DC81BINDING SITE FOR RESIDUE MG A 3835
ChainResidue
AG1973

DC92BINDING SITE FOR RESIDUE MG A 3836
ChainResidue
AC2107
AC2116

EC13BINDING SITE FOR RESIDUE MG A 3837
ChainResidue
AA2117
AA2146
AA2147

EC23BINDING SITE FOR RESIDUE MG A 3838
ChainResidue
AU1657
AG1658
AA2146

EC33BINDING SITE FOR RESIDUE MG A 3839
ChainResidue
AU1657
AG1658
AA1659

EC41BINDING SITE FOR RESIDUE MG A 3840
ChainResidue
AU1117

EC51BINDING SITE FOR RESIDUE MG A 3841
ChainResidue
AG1119

EC62BINDING SITE FOR RESIDUE MG A 3842
ChainResidue
AA2976
AU2977

EC71BINDING SITE FOR RESIDUE MG A 3843
ChainResidue
AA3043

EC81BINDING SITE FOR RESIDUE MG A 3844
ChainResidue
AG1293

EC92BINDING SITE FOR RESIDUE MG A 3846
ChainResidue
AA713
AU2672

FC13BINDING SITE FOR RESIDUE MG A 3847
ChainResidue
AA713
AC714
AU2672

FC22BINDING SITE FOR RESIDUE MG A 3848
ChainResidue
AU1301
AG1302

FC34BINDING SITE FOR RESIDUE MG A 3849
ChainResidue
AA1278
AU1279
AG1280
AC1327

FC43BINDING SITE FOR RESIDUE MG A 3850
ChainResidue
5LYS228
AA1297
AA1298

FC55BINDING SITE FOR RESIDUE MG A 3851
ChainResidue
AC1303
AU1305
AA1306
AA1307
KLYS24

FC62BINDING SITE FOR RESIDUE MG A 3852
ChainResidue
AU1296
AC1456

FC73BINDING SITE FOR RESIDUE MG A 3853
ChainResidue
AC273
AG274
AA325

FC82BINDING SITE FOR RESIDUE MG A 3855
ChainResidue
AA227
AA1566

FC91BINDING SITE FOR RESIDUE MG A 3856
ChainResidue
AA1566

GC11BINDING SITE FOR RESIDUE MG A 3857
ChainResidue
AA2679

GC22BINDING SITE FOR RESIDUE MG A 3858
ChainResidue
AA2526
AG2527

GC32BINDING SITE FOR RESIDUE MG A 3859
ChainResidue
AA2692
AG3233

GC44BINDING SITE FOR RESIDUE MG A 3860
ChainResidue
AA2690
AA2691
AU3232
AG3233

GC53BINDING SITE FOR RESIDUE MG A 3861
ChainResidue
AG2686
AG2688
AA3341

GC63BINDING SITE FOR RESIDUE MG A 3862
ChainResidue
AG2687
AG3304
AA3305

GC72BINDING SITE FOR RESIDUE MG A 3864
ChainResidue
AA3246
AU3247

GC81BINDING SITE FOR RESIDUE MG A 3865
ChainResidue
AA3471

GC94BINDING SITE FOR RESIDUE MG A 3866
ChainResidue
AA3435
AU3436
AA3472
ELYS361

HC12BINDING SITE FOR RESIDUE MG A 3867
ChainResidue
AA3727
AA3728

HC23BINDING SITE FOR RESIDUE MG A 3868
ChainResidue
AG2696
AC3229
AG3230

HC32BINDING SITE FOR RESIDUE MG A 3869
ChainResidue
AG3174
AG3230

HC41BINDING SITE FOR RESIDUE MG A 3870
ChainResidue
AC1681

HC52BINDING SITE FOR RESIDUE MG A 3871
ChainResidue
AA1684
AG1685

HC62BINDING SITE FOR RESIDUE MG A 3872
ChainResidue
AA936
AC937

HC72BINDING SITE FOR RESIDUE MG A 3874
ChainResidue
AU49
AU97

HC81BINDING SITE FOR RESIDUE MG A 3875
ChainResidue
AU287

HC92BINDING SITE FOR RESIDUE MG A 3876
ChainResidue
AA1688
AG1701

IC14BINDING SITE FOR RESIDUE MG A 3877
ChainResidue
AG641
AA642
AG643
AG644

IC21BINDING SITE FOR RESIDUE MG A 3878
ChainResidue
AA2176

IC32BINDING SITE FOR RESIDUE MG A 3879
ChainResidue
AG994
AC996

IC46BINDING SITE FOR RESIDUE MG A 3880
ChainResidue
AU3186
AG3187
AU3188
AG3189
AC3216
AU3217

IC51BINDING SITE FOR RESIDUE MG A 3881
ChainResidue
AG3190

IC61BINDING SITE FOR RESIDUE MG A 3882
ChainResidue
AG3470

IC71BINDING SITE FOR RESIDUE MG A 3883
ChainResidue
AC2626

IC81BINDING SITE FOR RESIDUE MG A 3884
ChainResidue
AA3261

IC92BINDING SITE FOR RESIDUE MG A 3885
ChainResidue
AG2170
AU2171

JC13BINDING SITE FOR RESIDUE MG A 3886
ChainResidue
AG3233
AG3304
AU3339

JC22BINDING SITE FOR RESIDUE MG A 3887
ChainResidue
AA3315
AG3316

JC33BINDING SITE FOR RESIDUE MG A 3888
ChainResidue
AG1337
AU1338
AA3507

JC42BINDING SITE FOR RESIDUE MG A 3889
ChainResidue
AG3697
AA3768

JC52BINDING SITE FOR RESIDUE MG A 3890
ChainResidue
AU1038
AU1041

JC63BINDING SITE FOR RESIDUE MG A 3891
ChainResidue
AA2431
AU2433
AU2434

JC71BINDING SITE FOR RESIDUE MG A 3892
ChainResidue
AC1665

JC82BINDING SITE FOR RESIDUE MG A 3893
ChainResidue
AG1640
eGLY2

JC92BINDING SITE FOR RESIDUE MG A 3894
ChainResidue
AG1634
AG1635

KC14BINDING SITE FOR RESIDUE MG A 3895
ChainResidue
AG1637
AA1748
AA2102
AC2103

KC22BINDING SITE FOR RESIDUE MG A 3896
ChainResidue
AU1747
AC2103

KC31BINDING SITE FOR RESIDUE MG A 3897
ChainResidue
AG33

KC41BINDING SITE FOR RESIDUE MG A 3898
ChainResidue
AA52

KC53BINDING SITE FOR RESIDUE MG A 3899
ChainResidue
AG21
AG22
AG56

KC63BINDING SITE FOR RESIDUE MG A 3900
ChainResidue
AG924
AA925
AU1053

KC73BINDING SITE FOR RESIDUE MG A 3901
ChainResidue
AG3182
AU3219
AU3220

KC81BINDING SITE FOR RESIDUE MG A 3902
ChainResidue
AG976

KC91BINDING SITE FOR RESIDUE MG A 3903
ChainResidue
AG2427

LC13BINDING SITE FOR RESIDUE MG A 3904
ChainResidue
AG2696
AA2697
AA3172

LC21BINDING SITE FOR RESIDUE MG A 3905
ChainResidue
AU1058

LC32BINDING SITE FOR RESIDUE MG A 3906
ChainResidue
AG366
AG2112

LC41BINDING SITE FOR RESIDUE MG A 3907
ChainResidue
AC2111

LC54BINDING SITE FOR RESIDUE MG A 3908
ChainResidue
AU84
AG86
AG795
AC796

LC62BINDING SITE FOR RESIDUE MG A 3909
ChainResidue
AA1582
AG1583

LC72BINDING SITE FOR RESIDUE MG A 3910
ChainResidue
AG730
AA2654

LC85BINDING SITE FOR RESIDUE MG A 3911
ChainResidue
AU408
AA409
AG416
AU1563
AG1564

LC92BINDING SITE FOR RESIDUE MG A 3912
ChainResidue
AA2572
AG2595

MC13BINDING SITE FOR RESIDUE MG A 3913
ChainResidue
AG736
AG737
AC1581

MC22BINDING SITE FOR RESIDUE MG A 3914
ChainResidue
AA1518
AG1519

MC32BINDING SITE FOR RESIDUE MG A 3915
ChainResidue
AU1061
AG1583

MC43BINDING SITE FOR RESIDUE MG A 3916
ChainResidue
8ASP39
AU718
AA723

MC53BINDING SITE FOR RESIDUE MG A 3917
ChainResidue
AG722
AA3176
AU3227

MC62BINDING SITE FOR RESIDUE MG A 3918
ChainResidue
AG1082
AG1243

MC75BINDING SITE FOR RESIDUE MG A 3919
ChainResidue
AA2440
AU2441
AG2480
DLYS198
DARG200

MC81BINDING SITE FOR RESIDUE MG A 3920
ChainResidue
AC3318

MC92BINDING SITE FOR RESIDUE MG A 3921
ChainResidue
AG2608
AC3319

NC12BINDING SITE FOR RESIDUE MG A 3922
ChainResidue
AU2567
AA2568

NC23BINDING SITE FOR RESIDUE MG A 3923
ChainResidue
AG2566
AG2604
AU3321

NC33BINDING SITE FOR RESIDUE MG A 3924
ChainResidue
AU990
AU2434
AA2435

NC44BINDING SITE FOR RESIDUE MG A 3925
ChainResidue
AG3439
AU3440
AA3471
AG3473

NC53BINDING SITE FOR RESIDUE MG A 3926
ChainResidue
AA2164
AG2165
AG2628

NC62BINDING SITE FOR RESIDUE MG A 3927
ChainResidue
AA1673
AU2101

NC72BINDING SITE FOR RESIDUE MG A 3928
ChainResidue
AC1676
AG1677

NC84BINDING SITE FOR RESIDUE MG A 3929
ChainResidue
AA727
AC728
AA3231
AU3232

NC93BINDING SITE FOR RESIDUE MG A 3930
ChainResidue
AA935
AA936
cGLN33

OC11BINDING SITE FOR RESIDUE MG A 3931
ChainResidue
AU1628

OC21BINDING SITE FOR RESIDUE MG A 3932
ChainResidue
AG997

OC32BINDING SITE FOR RESIDUE MG A 3933
ChainResidue
AC1627
AU2138

OC44BINDING SITE FOR RESIDUE MG A 3934
ChainResidue
AC1627
AU1628
AG1629
AU2138

OC52BINDING SITE FOR RESIDUE MG A 3935
ChainResidue
AA738
AU1579

OC62BINDING SITE FOR RESIDUE MG A 3936
ChainResidue
AA1118
AA1170

OC73BINDING SITE FOR RESIDUE MG A 3937
ChainResidue
AA39
AG41
AC42

OC82BINDING SITE FOR RESIDUE MG A 3938
ChainResidue
AU36
AU2950

OC91BINDING SITE FOR RESIDUE MG A 3939
ChainResidue
AA2706

PC12BINDING SITE FOR RESIDUE MG A 3940
ChainResidue
AA58
CG38

PC21BINDING SITE FOR RESIDUE MG A 3941
ChainResidue
AC329

PC32BINDING SITE FOR RESIDUE MG A 3942
ChainResidue
AA70
AG311

PC42BINDING SITE FOR RESIDUE MG A 3943
ChainResidue
AG353
AA356

PC53BINDING SITE FOR RESIDUE MG A 3944
ChainResidue
AG353
AA355
FGLY99

PC64BINDING SITE FOR RESIDUE MG A 3945
ChainResidue
AC413
AC414
AU415
AG416

PC74BINDING SITE FOR RESIDUE MG A 3946
ChainResidue
AA608
AC609
AG611
AG612

PC82BINDING SITE FOR RESIDUE MG A 3947
ChainResidue
AA1122
AA1169

PC92BINDING SITE FOR RESIDUE MG A 3948
ChainResidue
AC3248
AA3249

QC11BINDING SITE FOR RESIDUE MG A 3949
ChainResidue
AU83

QC21BINDING SITE FOR RESIDUE MG A 3950
ChainResidue
AG1540

QC31BINDING SITE FOR RESIDUE MG A 3951
ChainResidue
AA2660

QC43BINDING SITE FOR RESIDUE MG A 3952
ChainResidue
AU1645
AC1646
AA1663

QC51BINDING SITE FOR RESIDUE MG A 3953
ChainResidue
AG1662

QC62BINDING SITE FOR RESIDUE MG B 201
ChainResidue
BG83
BU84

QC74BINDING SITE FOR RESIDUE MG B 202
ChainResidue
BG21
BU53
BA54
BA55

QC81BINDING SITE FOR RESIDUE MG B 203
ChainResidue
BG65

QC92BINDING SITE FOR RESIDUE MG C 201
ChainResidue
AA1569
CU24

RC12BINDING SITE FOR RESIDUE MG C 202
ChainResidue
CA108
CU109

RC21BINDING SITE FOR RESIDUE MG C 204
ChainResidue
CA69

RC31BINDING SITE FOR RESIDUE MG C 205
ChainResidue
CA7

RC42BINDING SITE FOR RESIDUE MG M 201
ChainResidue
AG3276
MASN49

RC52BINDING SITE FOR RESIDUE MG Q 301
ChainResidue
AG1254
QASN14

RC65BINDING SITE FOR RESIDUE ZN a 200
ChainResidue
aCYS44
aCYS47
aTHR49
aCYS81
aCYS84

RC75BINDING SITE FOR RESIDUE ZN c 100
ChainResidue
cCYS22
cCYS25
cCYS37
cSER39
cCYS40

RC84BINDING SITE FOR RESIDUE ZN f 100
ChainResidue
fCYS20
fCYS23
fCYS34
fCYS39

RC94BINDING SITE FOR RESIDUE ZN h 100
ChainResidue
hCYS39
hCYS42
hCYS57
hCYS60

SC15BINDING SITE FOR RESIDUE ZN i 201
ChainResidue
iCYS12
iASN14
iCYS16
iCYS73
iCYS76

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails

> Sequence Neighbor

Sequence navigator - 3j79: Chain A
Sequence navigator - 3j79: Chain B
Sequence navigator - 3j79: Chain C
Sequence navigator - 3j79: Chain D
Sequence navigator - 3j79: Chain E
Sequence navigator - 3j79: Chain F
Sequence navigator - 3j79: Chain G
Sequence navigator - 3j79: Chain H
Sequence navigator - 3j79: Chain I
Sequence navigator - 3j79: Chain J
Sequence navigator - 3j79: Chain K
Sequence navigator - 3j79: Chain L
Sequence navigator - 3j79: Chain M
Sequence navigator - 3j79: Chain N
Sequence navigator - 3j79: Chain O
Sequence navigator - 3j79: Chain P
Sequence navigator - 3j79: Chain Q
Sequence navigator - 3j79: Chain R
Sequence navigator - 3j79: Chain S
Sequence navigator - 3j79: Chain T
Sequence navigator - 3j79: Chain U
Sequence navigator - 3j79: Chain V
Sequence navigator - 3j79: Chain W
Sequence navigator - 3j79: Chain X
Sequence navigator - 3j79: Chain Y
Sequence navigator - 3j79: Chain Z
Sequence navigator - 3j79: Chain 0
Sequence navigator - 3j79: Chain 1
Sequence navigator - 3j79: Chain 2
Sequence navigator - 3j79: Chain 3
Sequence navigator - 3j79: Chain 4
Sequence navigator - 3j79: Chain 5
Sequence navigator - 3j79: Chain 6
Sequence navigator - 3j79: Chain 7
Sequence navigator - 3j79: Chain 8
Sequence navigator - 3j79: Chain 9
Sequence navigator - 3j79: Chain a
Sequence navigator - 3j79: Chain b
Sequence navigator - 3j79: Chain c
Sequence navigator - 3j79: Chain d
Sequence navigator - 3j79: Chain e
Sequence navigator - 3j79: Chain f
Sequence navigator - 3j79: Chain g
Sequence navigator - 3j79: Chain h
Sequence navigator - 3j79: Chain i

> Downloads

PDBj@FacebookPDBj@TwitterwwPDBwwPDB FoundationEM DataBank

Copyright © 2013-2017 Protein Data Bank Japan