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7SIY
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BU of 7siy by Molmil
cCBL TKB domain in complex with pZAP70 peptide
Descriptor: E3 ubiquitin-protein ligase CBL, MAGNESIUM ION, Peptide from Tyrosine-protein kinase ZAP-70
Authors:Murray, J.M, Yu, C.
Deposit date:2021-10-15
Release date:2022-11-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:cCBL TKB domain in complex with pZAP70 peptide
To Be Published
3BUO
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BU of 3buo by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
Descriptor: 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
1B47
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BU of 1b47 by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
Descriptor: CALCIUM ION, CBL
Authors:Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
Deposit date:1999-01-06
Release date:1999-04-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
2CBL
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BU of 2cbl by Molmil
N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70
Descriptor: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70
Authors:Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
Deposit date:1998-08-28
Release date:1999-05-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
5O76
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BU of 5o76 by Molmil
Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2017-06-08
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.473 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
6XAR
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BU of 6xar by Molmil
Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2)
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Src-like-adapter 2
Authors:Wybenga-Groot, L.E, McGlade, C.J.
Deposit date:2020-06-04
Release date:2021-03-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function.
J.Mol.Biol., 433, 2021
8GCY
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BU of 8gcy by Molmil
Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor
Descriptor: 1,2-ETHANEDIOL, 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, ...
Authors:Kimani, S, Zeng, H, Dong, A, Li, Y, Santhakumar, V, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2023-03-03
Release date:2023-03-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition.
Commun Biol, 6, 2023
1FBV
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BU of 1fbv by Molmil
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Descriptor: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
Authors:Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P.
Deposit date:2000-07-17
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
5AXI
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BU of 5axi by Molmil
Crystal structure of Cbl-b TKB domain in complex with Cblin
Descriptor: CALCIUM ION, CHLORIDE ION, Cblin, ...
Authors:Ohno, A, Maita, N, Ochi, A, Nakao, R, Nikawa, T.
Deposit date:2015-07-29
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin
Arch.Biochem.Biophys., 594, 2016
4GPL
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BU of 4gpl by Molmil
Structure of Cbl(TKB) bound to a phosphorylated pentapeptide
Descriptor: ACE-PTR-THR-PRO-GLU-PRO, PEPTIDE INHIBITOR, E3 ubiquitin-protein ligase CBL
Authors:Borgstahl, G, Natarajan, A.
Deposit date:2012-08-21
Release date:2013-09-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides.
Sci Rep, 3, 2013
1YVH
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BU of 1yvh by Molmil
Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide
Descriptor: 13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION
Authors:Hu, J, Hubbard, S.R.
Deposit date:2005-02-15
Release date:2005-03-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
J.Biol.Chem., 280, 2005
6BK5
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BU of 6bk5 by Molmil
Inactive choanoflagellate E3 ubiquitin ligase Cbl TKB
Descriptor: CALCIUM ION, Ubiquitin Ligase Cbl
Authors:Amacher, J.F, Kuriyan, J.
Deposit date:2017-11-07
Release date:2018-03-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.
Protein Sci., 27, 2018
6O02
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BU of 6o02 by Molmil
Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
Descriptor: E3 ubiquitin-protein ligase CBL, Monobody (MC3)
Authors:Kukenshoner, T, Pojer, F, Hantschel, O.
Deposit date:2019-02-15
Release date:2020-08-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.953 Å)
Cite:Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
To Be Published
6O03
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BU of 6o03 by Molmil
Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
Descriptor: E3 ubiquitin-protein ligase CBL, Monobody (MC17)
Authors:Kukenshoner, T, Pojer, F, Hantschel, O.
Deposit date:2019-02-15
Release date:2020-08-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Monobody (MC17) bound to tyrosine kinase binding domain of E3 ligase CBL
To Be Published
3ZNI
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BU of 3zni by Molmil
Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL-B, ...
Authors:Dou, H, Buetow, L, Sibbet, G.J, Cameron, K, Huang, D.T.
Deposit date:2013-02-14
Release date:2013-07-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3.
Nat.Struct.Mol.Biol., 20, 2013
4A4C
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BU of 4a4c by Molmil
Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ...
Authors:Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4A4B
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BU of 4a4b by Molmil
Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ...
Authors:Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
8VW5
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BU of 8vw5 by Molmil
Crystal structure of Cbl-b TKB bound to compound 2
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL-B, MAGNESIUM ION, ...
Authors:Yu, C, Murray, J, Hsu, P.L.
Deposit date:2024-01-31
Release date:2024-07-03
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Acs Med.Chem.Lett., 15, 2024
8VW4
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BU of 8vw4 by Molmil
Crystal structure of Cbl-b TKB bound to compound 26
Descriptor: (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ...
Authors:Yu, C, Murray, J, Hsu, P.L.
Deposit date:2024-01-31
Release date:2024-07-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Acs Med.Chem.Lett., 15, 2024
3PLF
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BU of 3plf by Molmil
Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain
Descriptor: CALCIUM ION, CHLORIDE ION, E3 ubiquitin-protein ligase CBL, ...
Authors:Sun, Q, Sivaraman, J.
Deposit date:2010-11-15
Release date:2010-12-01
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Febs Lett., 585, 2011
3OB2
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BU of 3ob2 by Molmil
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide
Descriptor: 12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Sun, Q, Sivaraman, J.
Deposit date:2010-08-06
Release date:2010-08-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OP0
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BU of 3op0 by Molmil
Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
Descriptor: Epidermal growth factor receptor, NICKEL (II) ION, SODIUM ION, ...
Authors:Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Ugochukwu, E, Muniz, J.R.C, Vollmar, M, Canning, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published
9FQI
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BU of 9fqi by Molmil
E3 ligase Cbl-b in complex with a lactam scaffold inhibitor (compound 7)
Descriptor: 8-[3-[(4~{R})-4-methyl-2-oxidanylidene-piperidin-4-yl]phenyl]-3-[[(3~{S})-3-methylpiperidin-1-yl]methyl]-5-(trifluoromethyl)-1$l^{4},7,8-triazabicyclo[4.3.0]nona-1(6),2,4-trien-9-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ...
Authors:Schimpl, M.
Deposit date:2024-06-17
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.954 Å)
Cite:Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.
J.Med.Chem., 67, 2024
9FQJ
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BU of 9fqj by Molmil
E3 ligase Cbl-b in complex with a carbamate scaffold inhibitor (compound 12)
Descriptor: 2-cyclopropyl-6-methyl-~{N}-[3-[(6~{S})-6-methyl-2-oxidanylidene-1,3-oxazinan-6-yl]phenyl]pyrimidine-4-carboxamide, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ...
Authors:Schimpl, M.
Deposit date:2024-06-17
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.563 Å)
Cite:Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.
J.Med.Chem., 67, 2024
3PFV
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BU of 3pfv by Molmil
Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
Descriptor: 1,2-ETHANEDIOL, 11-meric peptide from Epidermal growth factor receptor, CHLORIDE ION, ...
Authors:Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Muniz, J.R.C, Vollmar, M, Canning, P, Gileadi, O, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-10-29
Release date:2010-12-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
To be Published

 

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