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3OP0

Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide

Summary for 3OP0
Entry DOI10.2210/pdb3op0/pdb
DescriptorSignal transduction protein CBL-C, Epidermal growth factor receptor, SODIUM ION, ... (5 entities in total)
Functional Keywordsstructural genomics, structural genomics consortium, sgc, signal transduction protein, sh3-binding protein, signaling protein-signaling protein regulator complex, signaling protein/signaling protein regulator
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains4
Total formula weight75084.49
Authors
Primary citationChaikuad, A.,Guo, K.,Cooper, C.D.O.,Ayinampudi, V.,Krojer, T.,Ugochukwu, E.,Muniz, J.R.C.,Vollmar, M.,Canning, P.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Bountra, C.,Bullock, A.
Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published,
Experimental method
X-RAY DIFFRACTION (2.52 Å)
Structure validation

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