3OP0
Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Signal transduction protein CBL-C | polymer | 323 | 36185.3 | 2 | UniProt (Q9ULV8) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) | Homo sapiens (human) | SH3-binding protein CBL-C, SH3-binding protein CBL-3, RING finger protein 57 |
| 2 | C, D (C, D) | Epidermal growth factor receptor | polymer | 11 | 1275.2 | 2 | UniProt (P00533) | Homo sapiens | Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1 |
| 3 | E, G (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | F, H (A, B) | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 323 (UniProt: Q9ULV8)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | expression tag |
| Glu 64 | Ala 64 | engineered mutation |
| Ala 324 | - | expression tag |
| Glu 325 | - | expression tag |
| Asn 326 | - | expression tag |
| Leu 327 | - | expression tag |
| Tyr 328 | - | expression tag |
| Phe 329 | - | expression tag |
| Gln 330 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74921.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 163.4 | |
| All* | Total formula weight | 75084.5 |
