3PFV

Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide

Summary for 3PFV

• Entry DOI: 10.2210/pdb3pfv/pdb
• Descriptor: E3 ubiquitin-protein ligase CBL-B, 11-meric peptide from Epidermal growth factor receptor, SODIUM ION, ... (8 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, signal transduction protein, cbl-b, sh3-binding protein, ligase-protein binding complex, ligase/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q13191; Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 4
• Total formula weight: 77583.04

Authors

Chaikuad, A.,Guo, K.,Cooper, C.D.O.,Ayinampudi, V.,Krojer, T.,Muniz, J.R.C.,Vollmar, M.,Canning, P.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-10-29, release date: 2010-12-08, Last modification date: 2023-12-06)

• Primary citation: Chaikuad, A.,Guo, K.,Cooper, C.D.O.,Ayinampudi, V.,Krojer, T.,Muniz, J.R.C.,Vollmar, M.,Canning, P.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC); Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide; To be Published,

Experimental method

X-RAY DIFFRACTION (2.27 Å)