3PFV
Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0023051 | biological_process | regulation of signaling |
| B | 0001784 | molecular_function | phosphotyrosine residue binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0023051 | biological_process | regulation of signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1 |
| Chain | Residue |
| A | ASP221 |
| A | THR223 |
| A | ASN225 |
| A | TYR227 |
| A | GLU232 |
| A | HOH432 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 3 |
| Chain | Residue |
| A | HOH409 |
| A | HOH410 |
| A | ASN104 |
| A | GLU105 |
| A | TYR106 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 4 |
| Chain | Residue |
| A | HIS312 |
| A | ASN313 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | THR174 |
| A | LYS175 |
| A | ARG238 |
| A | GLN241 |
| A | HOH444 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 352 |
| Chain | Residue |
| A | ARG335 |
| A | SER336 |
| B | GLN206 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | ARG325 |
| A | HOH393 |
| B | ARG44 |
| B | LYS48 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 7 |
| Chain | Residue |
| A | ARG172 |
| B | ARG291 |
| D | LEU1066 |
| D | ARG1068 |
| D | PTR1069 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 8 |
| Chain | Residue |
| A | LYS195 |
| A | ARG198 |
| B | ARG272 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 9 |
| Chain | Residue |
| A | HOH430 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 10 |
| Chain | Residue |
| A | ARG272 |
| A | HOH437 |
| B | ARG198 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 2 |
| Chain | Residue |
| B | ASP221 |
| B | THR223 |
| B | ASN225 |
| B | TYR227 |
| B | GLU232 |
| B | HOH388 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1 |
| Chain | Residue |
| B | LYS175 |
| B | ARG238 |
| B | GLN241 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3 |
| Chain | Residue |
| A | GLN206 |
| B | HOH25 |
| B | ARG335 |
| B | SER336 |
| B | HOH392 |
| B | HOH406 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| B | GLN138 |
| B | ARG141 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 B 11 |
| Chain | Residue |
| A | ARG141 |
| A | HOH436 |
| B | TRP194 |
| B | MET214 |
| B | HOH398 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 144 |
| Details | Region: {"description":"EF-hand-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 204 |
| Details | Region: {"description":"SH2-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P22681","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCQ","evidences":[{"source":"PubMed","id":"19549985","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23774213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22888118","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"3138233","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
