3PFV
Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase CBL-B | polymer | 315 | 36931.4 | 2 | UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) | Homo sapiens (human) | Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56, SH3-binding protein CBL-B, Signal transduction protein CBL-B |
| 2 | C, D (C, D) | 11-meric peptide from Epidermal growth factor receptor | polymer | 11 | 1275.2 | 2 | UniProt (P00533) | Homo sapiens | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 3 | E, O (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | H, I, J, K, P... (A, B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 6 | L, M, N (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 7 | S (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 8 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 38 - 344 (UniProt: Q13191)
| PDB | External Database | Details |
|---|---|---|
| Met 37 | - | initiating methionine |
| Ala 345 | - | expression tag |
| Glu 346 | - | expression tag |
| Asn 347 | - | expression tag |
| Leu 348 | - | expression tag |
| Tyr 349 | - | expression tag |
| Phe 350 | - | expression tag |
| Gln 351 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 76413.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1169.8 | |
| All* | Total formula weight | 77583.0 |
