3PFV
Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | E3 ubiquitin-protein ligase CBL-B | polymer | 315 | 36931.4 | 2 | UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) In PDB | Homo sapiens (human) | Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56, SH3-binding protein CBL-B, Signal transduction protein CBL-B |
2 | C, D | 11-meric peptide from Epidermal growth factor receptor | polymer | 11 | 1275.2 | 2 | UniProt (P00533) In PDB | Homo sapiens | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
3 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
4 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | A, B | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
7 | B | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
8 | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 38 - 344 (UniProt: Q13191)
PDB | External Database | Details |
---|---|---|
Met 37 | - | initiating methionine |
Ala 345 | - | expression tag |
Glu 346 | - | expression tag |
Asn 347 | - | expression tag |
Leu 348 | - | expression tag |
Tyr 349 | - | expression tag |
Phe 350 | - | expression tag |
Gln 351 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 76413.3 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 1169.8 | |
All* | Total formula weight | 77583.0 |