6NDS
| |
2FTP
| Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa | Descriptor: | GLYCEROL, SODIUM ION, hydroxymethylglutaryl-CoA lyase | Authors: | Xiao, T, Evdokimova, E, Liu, Y, Kudritska, M, Savchenko, A, Pai, E.F, Edwards, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2006-01-24 | Release date: | 2006-03-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa To be Published
|
|
6E1J
| |
6KTQ
| Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA | Descriptor: | 2-OXOGLUTARIC ACID, COENZYME A, Homocitrate synthase, ... | Authors: | Suzuki, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2019-08-28 | Release date: | 2020-09-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius. Febs J., 288, 2021
|
|
2CW6
| Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria | Descriptor: | 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, mitochondrial, ... | Authors: | Fu, Z, Runquist, J.A, Hunt, J.F, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2005-06-17 | Release date: | 2005-12-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria J.Biol.Chem., 281, 2006
|
|
2ZTK
| Crystal structure of homocitrate synthase from Thermus thermophilus complexed with homocitrate | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, COPPER (II) ION, Homocitrate synthase | Authors: | Okada, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2008-10-06 | Release date: | 2009-10-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus J.Biol.Chem., 285, 2010
|
|
2ZTJ
| Crystal structure of homocitrate synthase from Thermus thermophilus complexed with alpha-ketoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, COPPER (II) ION, Homocitrate synthase | Authors: | Okada, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2008-10-06 | Release date: | 2009-10-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus J.Biol.Chem., 285, 2010
|
|
2ZYF
| Crystal structure of homocitrate synthase from Thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, Homocitrate synthase, MAGNESIUM ION | Authors: | Okada, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2009-01-20 | Release date: | 2009-12-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from thermus thermophilus J.Biol.Chem., 2009
|
|
3RMJ
| Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis | Descriptor: | 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J. | Deposit date: | 2011-04-20 | Release date: | 2012-03-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding Biochemistry, 51, 2012
|
|
3MP4
| Crystal structure of Human lyase R41M mutant | Descriptor: | Hydroxymethylglutaryl-CoA lyase | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2010-04-24 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285, 2010
|
|
3MP3
| Crystal Structure of Human Lyase in complex with inhibitor HG-CoA | Descriptor: | (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ... | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2010-04-24 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285, 2010
|
|
3MP5
| Crystal Structure of Human Lyase R41M in complex with HMG-CoA | Descriptor: | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, Hydroxymethylglutaryl-CoA lyase, MAGNESIUM ION | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2010-04-24 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285, 2010
|
|
3MI3
| Homocitrate Synthase Lys4 bound to Lysine | Descriptor: | Homocitrate synthase, mitochondrial, LYSINE, ... | Authors: | Bulfer, S.L, Scott, E.M, Pillus, L, Trievel, R.C. | Deposit date: | 2010-04-09 | Release date: | 2010-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase J.Biol.Chem., 285, 2010
|
|
3U6W
| Truncated M. tuberculosis LeuA (1-425) complexed with KIV | Descriptor: | 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, GLYCEROL, ... | Authors: | Koon, N, Baker, E.N, Squire, C.J. | Deposit date: | 2011-10-13 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding. Biochemistry, 51, 2012
|
|
1YDO
| Crystal Structure of the Bacillis subtilis HMG-CoA Lyase, Northeast Structural Genomics Target SR181. | Descriptor: | HMG-CoA Lyase, IODIDE ION | Authors: | Forouhar, F, Hussain, M, Edstrom, W, Vorobiev, S.M, Xiao, R, Ciano, M, Shih, L, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2004-12-24 | Release date: | 2005-07-05 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds. J.Biol.Chem., 281, 2006
|
|
1YDN
| Crystal Structure of the HMG-CoA Lyase from Brucella melitensis, Northeast Structural Genomics Target LR35. | Descriptor: | CALCIUM ION, HYDROXYMETHYLGLUTARYL-COA LYASE | Authors: | Forouhar, F, Abashidze, M, Hussain, M, Vorobiev, S.M, Xiao, R, Ciano, M, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2004-12-24 | Release date: | 2005-07-05 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds. J.Biol.Chem., 281, 2006
|
|
4OV9
| Structure of isopropylmalate synthase binding with alpha-isopropylmalate | Descriptor: | (2S)-2-hydroxy-2-(propan-2-yl)butanedioic acid, ZINC ION, isopropylmalate synthase | Authors: | Zhang, Z, Wu, J, Wang, C, Zhang, P. | Deposit date: | 2014-02-20 | Release date: | 2014-08-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J.Biol.Chem., 289, 2014
|
|
4OV4
| Isopropylmalate synthase binding with ketoisovalerate | Descriptor: | 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, ZINC ION | Authors: | Zhang, Z, Wu, J, Wang, C, Zhang, P. | Deposit date: | 2014-02-20 | Release date: | 2014-08-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J.Biol.Chem., 289, 2014
|
|
3A9I
| Crystal structure of homocitrate synthase from Thermus thermophilus complexed with Lys | Descriptor: | COBALT (II) ION, Homocitrate synthase, LYSINE | Authors: | Okada, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2009-10-28 | Release date: | 2009-12-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus J.Biol.Chem., 285, 2010
|
|
3BLI
| |
3BLE
| |
3BLF
| |
3HPX
| |
3IVS
| Homocitrate Synthase Lys4 | Descriptor: | COBALT (II) ION, Homocitrate synthase, mitochondrial, ... | Authors: | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | Deposit date: | 2009-09-01 | Release date: | 2009-09-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J.Biol.Chem., 284, 2009
|
|
3IVU
| Homocitrate Synthase Lys4 bound to 2-OG | Descriptor: | 2-OXOGLUTARIC ACID, COBALT (II) ION, Homocitrate synthase, ... | Authors: | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | Deposit date: | 2009-09-01 | Release date: | 2009-09-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J.Biol.Chem., 284, 2009
|
|