3HPX
Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)
Summary for 3HPX
| Entry DOI | 10.2210/pdb3hpx/pdb |
| Related | 1SR9 3FIG 3HPS 3HPZ 3HQ1 |
| Descriptor | 2-isopropylmalate synthase, NICKEL (II) ION, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | 2-isopropylmalate synthase, leua, mycobacterium tuberculosis, truncation mutant, active site domain, tim barrel, amino-acid biosynthesis, branched-chain amino acid biosynthesis, leucine biosynthesis, transferase |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 2 |
| Total formula weight | 95376.16 |
| Authors | Koon, N.,Squire, C.J.,Baker, E.N. (deposition date: 2009-06-05, release date: 2010-05-19, Last modification date: 2023-09-06) |
| Primary citation | Huisman, F.H.,Koon, N.,Bulloch, E.M.,Baker, H.M.,Baker, E.N.,Squire, C.J.,Parker, E.J. Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding Biochemistry, 51:2289-2297, 2012 Cited by PubMed: 22352945DOI: 10.1021/bi201717j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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