3U6W

Truncated M. tuberculosis LeuA (1-425) complexed with KIV

Summary for 3U6W

• Entry DOI: 10.2210/pdb3u6w/pdb
• Related: 1SR9 3FIG 3HPS 3HPX 3HPZ 3HQ1
• Descriptor: 2-isopropylmalate synthase, MANGANESE (II) ION, 3-METHYL-2-OXOBUTANOIC ACID, ... (5 entities in total)
• Functional Keywords: tim barrel, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 95857.14

Authors

Koon, N.,Baker, E.N.,Squire, C.J. (deposition date: 2011-10-13, release date: 2012-03-14, Last modification date: 2023-09-13)

• Primary citation: Huisman, F.H.,Koon, N.,Bulloch, E.M.,Baker, H.M.,Baker, E.N.,Squire, C.J.,Parker, E.J.; Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding.; Biochemistry, 51:2289-2297, 2012; PubMed: 22352945; DOI: 10.1021/bi201717j

Experimental method

X-RAY DIFFRACTION (2.21 Å)