6I50
| |
8KB6
| |
7SGM
| Crystal structure of a Fab variant containing a fluorescent noncanonical amino acid with blocked excited state proton transfer and in complex with its antigen, CD40L | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c8* Fab heavy chain, ... | 著者 | Henderson, J.N, Mills, J.H, Simmons, C.R. | 登録日 | 2021-10-06 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid-Containing Antibody Fragment. J.Mol.Biol., 434, 2022
|
|
5MU8
| HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525 | 分子名称: | Tumor necrosis factor, ~{N}4-(phenylmethyl)-~{N}4-[2-[3-(2-piperazin-1-ylpyrimidin-5-yl)phenyl]phenyl]pyrimidine-2,4-diamine | 著者 | Blevitt, J.M, Hack, M.D, Herman, K.L, Jackson, P.F, Krawczuk, P.J, Lebsack, A.D, Liu, A.X, Mirzadegan, T, Nelen, M.I, Patrick, A.P, Steinbacher, S, Milla, M.E, Lumb, K.J. | 登録日 | 2017-01-12 | 公開日 | 2017-03-29 | 最終更新日 | 2019-02-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. J. Med. Chem., 60, 2017
|
|
8SLR
| |
3WD5
| Crystal structure of TNFalpha in complex with Adalimumab Fab fragment | 分子名称: | Adalimumab Heavy Chain, Adalimumab Light Chain, Tumor necrosis factor | 著者 | Hu, S, Liang, S.Y, Guo, Y.J, Lou, Z.Y. | 登録日 | 2013-06-06 | 公開日 | 2013-08-14 | 最終更新日 | 2015-07-01 | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | 主引用文献 | Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor alpha-associated diseases from a molecular view J.Biol.Chem., 288, 2013
|
|
7X9G
| Crystal structure of human EDA and EDAR | 分子名称: | Ectodysplasin-A, secreted form, Tumor necrosis factor receptor superfamily member EDAR | 著者 | Yu, K, Wan, F, Huang, C, Wu, J, Lei, M. | 登録日 | 2022-03-15 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants. Nat Commun, 14, 2023
|
|
8Z8M
| |
6ZT0
| Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex | 分子名称: | 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald | 著者 | Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M. | 登録日 | 2020-07-17 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions. Nat Commun, 12, 2021
|
|
6RMJ
| Crystal structure of human NGR-TNF | 分子名称: | Tumor necrosis factor | 著者 | Degano, M, Garau, G. | 登録日 | 2019-05-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling. Int J Mol Sci, 20, 2019
|
|
3FC0
| 1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells | 分子名称: | ACETATE ION, GITR ligand | 著者 | Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | 登録日 | 2008-11-20 | 公開日 | 2008-12-30 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells. Acta Crystallogr.,Sect.D, 65, 2009
|
|
7TA6
| Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1 | 分子名称: | 1,2-ETHANEDIOL, AMINO GROUP, Alpha/Beta-peptide-1, ... | 著者 | Niu, J, Bingman, C.A, Gellman, S.H. | 登録日 | 2021-12-20 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling. J.Am.Chem.Soc., 144, 2022
|
|
1ALY
| |
7TA3
| |
1A8M
| TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT | 分子名称: | TUMOR NECROSIS FACTOR ALPHA | 著者 | Reed, C, Fu, Z.-Q, Wu, J, Xue, Y.-N, Harrison, R.W, Chen, M.-J, Weber, I.T. | 登録日 | 1998-03-27 | 公開日 | 1998-06-17 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2. Protein Eng., 10, 1997
|
|
6FXN
| Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab | 分子名称: | Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain | 著者 | Lammens, A, Maskos, K, Willen, L, Jiang, X, Schneider, P. | 登録日 | 2018-03-09 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors. Nat Commun, 9, 2018
|
|
4ZCH
| Single-chain human APRIL-BAFF-BAFF Heterotrimer | 分子名称: | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B | 著者 | Lammens, A, Jiang, X, Maskos, K, Schneider, P. | 登録日 | 2015-04-16 | 公開日 | 2015-05-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties. J.Biol.Chem., 290, 2015
|
|
6FIB
| Structure of human 4-1BB ligand | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein | 著者 | Joseph, C, Claus, C, Ferrara, C, von Hirschheydt, T, Prince, C, Funk, D, Klein, C, Benz, J. | 登録日 | 2018-01-17 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy. Sci Transl Med, 11, 2019
|
|
7DOV
| |
2E7A
| |
2O0O
| Crystal structure of TL1A | 分子名称: | MAGNESIUM ION, TNF superfamily ligand TL1A | 著者 | Jin, T.C, Kim, S, Guo, F, Howard, A.J, Zhang, Y.Z. | 登録日 | 2006-11-27 | 公開日 | 2007-10-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | X-ray crystal structure of TNF ligand family member TL1A at 2.1A. Biochem.Biophys.Res.Commun., 364, 2007
|
|
2AZ5
| Crystal Structure of TNF-alpha with a small molecule inhibitor | 分子名称: | 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE, Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, ... | 著者 | He, M.M. | 登録日 | 2005-09-09 | 公開日 | 2005-11-29 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Small-molecule inhibition of TNF-alpha. Science, 310, 2005
|
|
7E57
| Crystal structure of murine GITR-GITRL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18, ... | 著者 | Zhao, M, Tan, S, Fu, L, Chai, Y, Qi, J, Gao, G.F. | 登録日 | 2021-02-18 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.302 Å) | 主引用文献 | Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation. Cell Rep, 36, 2021
|
|
2Q8O
| |
5TSW
| |