Summary for 5TSW
| Entry DOI | 10.2210/pdb5tsw/pdb |
| Descriptor | PROTEIN (TUMOR NECROSIS FACTOR-ALPHA) (2 entities in total) |
| Functional Keywords | lymphokine, low systemic toxicity, mutant |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375 |
| Total number of polymer chains | 6 |
| Total formula weight | 99472.78 |
| Authors | Cha, S.-S.,Kim, J.-S.,Cho, H.-S.,Oh, B.-H. (deposition date: 1999-04-22, release date: 1999-05-07, Last modification date: 2023-12-27) |
| Primary citation | Cha, S.S.,Kim, J.S.,Cho, H.S.,Shin, N.K.,Jeong, W.,Shin, H.C.,Kim, Y.J.,Hahn, J.H.,Oh, B.H. High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity. J.Biol.Chem., 273:2153-2160, 1998 Cited by PubMed: 9442056DOI: 10.1074/jbc.273.4.2153 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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