5TSW

HIGH RESOLUTION CRYSTAL STRUCTURE OF A HUMAN TNF-ALPHA MUTANT

Replaces:  4TSW

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	PROTEIN (TUMOR NECROSIS FACTOR-ALPHA)	polymer	150	16578.8	6	UniProt (P01375) Pfam (PF00229)	Homo sapiens (human)
2	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	356	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 8 - 157 (UniProt: P01375)

PDB	External Database	Details
Ser 29	Leu 105	engineered mutation
Ile 52	Ser 128	engineered mutation
Phe 56	Tyr 132	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	99472.8
All*	Total formula weight	99472.8

*Water molecules are not included.