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7SGM

Crystal structure of a Fab variant containing a fluorescent noncanonical amino acid with blocked excited state proton transfer and in complex with its antigen, CD40L

Summary for 7SGM
Entry DOI10.2210/pdb7sgm/pdb
DescriptorCD40 ligand, 5c8* Fab heavy chain, 5c8* Fab light chain, ... (8 entities in total)
Functional Keywordsfragment antigen binding (fab), noncanonical amino acid, 7-hydroxycoumarin, immune system, cytokine-immune system complex, cytokine/immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains9
Total formula weight193887.32
Authors
Henderson, J.N.,Mills, J.H.,Simmons, C.R. (deposition date: 2021-10-06, release date: 2022-02-02, Last modification date: 2023-11-15)
Primary citationHenderson, J.N.,Simmons, C.R.,Mills, J.H.
Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid-Containing Antibody Fragment.
J.Mol.Biol., 434:167455-167455, 2022
Cited by
PubMed: 35033559
DOI: 10.1016/j.jmb.2022.167455
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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