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2ECW
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BU of 2ecw by Molmil
Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30
分子名称: Tripartite motif-containing protein 30, ZINC ION
著者Abe, H, Miyamoto, K, Tochio, N, Yoneyama, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-02-14
公開日2008-02-26
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30
To be Published
5YUF
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BU of 5yuf by Molmil
Crystal Structure of PML RING tetramer
分子名称: Protein PML, ZINC ION
著者Wang, P, Benhend, S, Wu, H, Breitenbach, V, Zhen, T, Jollivet, F, Peres, L, Li, Y, Chen, S, Chen, Z, de THE, H, Meng, G.
登録日2017-11-22
公開日2018-04-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献RING tetramerization is required for nuclear body biogenesis and PML sumoylation.
Nat Commun, 9, 2018
1BOR
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BU of 1bor by Molmil
TRANSCRIPTION FACTOR PML, A PROTO-ONCOPROTEIN, NMR, 1 REPRESENTATIVE STRUCTURE AT PH 7.5, 30 C, IN THE PRESENCE OF ZINC
分子名称: TRANSCRIPTION FACTOR PML, ZINC ION
著者Borden, K.L.B, Freemont, P.S.
登録日1995-09-27
公開日1997-04-01
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.
EMBO J., 14, 1995
4R7E
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BU of 4r7e by Molmil
Structure of Bre1 RING domain
分子名称: E3 ubiquitin-protein ligase BRE1, ZINC ION
著者Kumar, P, Wolberger, C.
登録日2014-08-27
公開日2015-05-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.251 Å)
主引用文献Structure of the yeast Bre1 RING domain.
Proteins, 83, 2015
2K4D
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BU of 2k4d by Molmil
E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity
分子名称: E3 ubiquitin-protein ligase CBL, ZINC ION
著者Huang, A, De Jong, R.N, Wienk, H, Winkler, S.G, Timmers, H.T.M, Boelens, R.
登録日2008-06-06
公開日2009-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity
J.Mol.Biol., 385, 2009
2LDR
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BU of 2ldr by Molmil
Solution structure of Helix-RING domain of Cbl-b in the Tyr363 phosphorylated form
分子名称: E3 ubiquitin-protein ligase CBL-B, ZINC ION
著者Kumeta, H, Kobashigawa, Y, Inagaki, F.
登録日2011-06-01
公開日2011-12-14
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
Proc.Natl.Acad.Sci.USA, 108, 2011
2MWX
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BU of 2mwx by Molmil
The RING Domain of human Promyelocytic Leukemia Protein (PML)
分子名称: Protein PML, ZINC ION
著者Huang, S.Y, Chang, C.F, Fan, P.J, Guntert, P, Shih, H.M, Huang, T.H.
登録日2014-12-02
公開日2015-02-11
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The RING domain of human promyelocytic leukemia protein (PML).
J.Biomol.Nmr, 61, 2015
1CHC
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BU of 1chc by Molmil
STRUCTURE OF THE C3HC4 DOMAIN BY 1H-NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; A NEW STRUCTURAL CLASS OF ZINC-FINGER
分子名称: EQUINE HERPES VIRUS-1 RING DOMAIN, ZINC ION
著者Barlow, P.N, Everett, R.D, Luisi, B.
登録日1994-02-02
公開日1994-04-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-finger.
J.Mol.Biol., 237, 1994
5H7R
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BU of 5h7r by Molmil
Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain
分子名称: E3 ubiquitin-protein ligase LNX, ZINC ION
著者Nayak, D, Sivaraman, J.
登録日2016-11-21
公開日2017-11-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.
J. Mol. Biol., 430, 2018
5TRB
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BU of 5trb by Molmil
Crystal structure of the RNF20 RING domain
分子名称: E3 ubiquitin-protein ligase BRE1A, ZINC ION
著者Foglizzo, M, Middleton, A.J, Day, C.L.
登録日2016-10-25
公開日2016-11-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.
J.Mol.Biol., 428, 2016
7BBD
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BU of 7bbd by Molmil
Crystal structure of monoubiquitinated TRIM21 RING (Ub-RING) In complex with ubiquitin charged Ube2N (Ube2N~Ub) and Ube2V2
分子名称: Polyubiquitin-B,E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, ...
著者Kiss, L, Neuhaus, D, James, L.C.
登録日2020-12-17
公開日2021-01-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
6FGA
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BU of 6fga by Molmil
Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating enzyme UBE2E1
分子名称: E3 ubiquitin-protein ligase TRIM21, GLYCEROL, Ubiquitin-conjugating enzyme E2 E1, ...
著者Anandapadamanaban, M, Moche, M, Sunnerhagen, M.
登録日2018-01-10
公開日2019-06-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
J.Biol.Chem., 294, 2019
3KNV
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BU of 3knv by Molmil
Crystal structure of the RING and first zinc finger domains of TRAF2
分子名称: TNF receptor-associated factor 2, ZINC ION
著者Yin, Q, Wu, H.
登録日2009-11-12
公開日2009-11-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
Biochemistry, 48, 2009
7LYB
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BU of 7lyb by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c
分子名称: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
登録日2021-03-06
公開日2021-07-28
最終更新日2021-09-01
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
1RMD
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BU of 1rmd by Molmil
RAG1 DIMERIZATION DOMAIN
分子名称: RAG1, ZINC ION
著者Bellon, S.F, Rodgers, K.K, Schatz, D.G, Coleman, J.E, Steitz, T.A.
登録日1997-01-10
公開日1997-07-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.
Nat.Struct.Biol., 4, 1997
7JZV
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BU of 7jzv by Molmil
Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome
分子名称: BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ...
著者Witus, S.R, Burrell, A.L, Hansen, J.M, Farrell, D.P, Dimaio, F, Kollman, J.M, Klevit, R.E.
登録日2020-09-02
公開日2021-02-17
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1.
Nat.Struct.Mol.Biol., 28, 2021
6S53
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BU of 6s53 by Molmil
Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ...
著者Kiss, L, Boland, A, Neuhaus, D, James, L.C.
登録日2019-06-30
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.
Nat Commun, 10, 2019
1JM7
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BU of 1jm7 by Molmil
Solution structure of the BRCA1/BARD1 RING-domain heterodimer
分子名称: BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, ZINC ION
著者Brzovic, P.S, Rajagopal, P, Hoyt, D.W, King, M.-C, Klevit, R.E.
登録日2001-07-17
公開日2001-10-03
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Nat.Struct.Biol., 8, 2001
3VGO
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BU of 3vgo by Molmil
Crystal structure of the N-terminal fragment of Cbl-b
分子名称: E3 ubiquitin-protein ligase CBL-B
著者Kobashigawa, Y, Noda, N.N, Inagaki, F.
登録日2011-08-18
公開日2011-12-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
Proc.Natl.Acad.Sci.USA, 108, 2011
8A58
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BU of 8a58 by Molmil
X-ray structure of TRIM21 RING E3 ligase in complex with E2 enzyme Ube2W
分子名称: E3 ubiquitin-protein ligase TRIM21, Ubiquitin-conjugating enzyme E2 W, ZINC ION
著者James, L.C, Kiss, L.
登録日2022-06-14
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Nat Commun, 14, 2023
5O76
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BU of 5o76 by Molmil
Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant
分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ...
著者Gabrielsen, M, Buetow, L, Huang, D.T.
登録日2017-06-08
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.473 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
2Y1M
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BU of 2y1m by Molmil
Structure of native c-Cbl
分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION
著者Dou, H, Sibbet, G.J, Huang, D.T.
登録日2010-12-08
公開日2012-01-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
4KBL
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BU of 4kbl by Molmil
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism
分子名称: E3 ubiquitin-protein ligase ARIH1, ZINC ION
著者Duda, D.M, Olszewski, J.L, Schulman, B.A.
登録日2013-04-23
公開日2013-05-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism.
Structure, 21, 2013
5OLM
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BU of 5olm by Molmil
TRIM21
分子名称: E3 ubiquitin-protein ligase TRIM21, ZINC ION
著者James, L.C.
登録日2017-07-28
公開日2018-04-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
Elife, 7, 2018
6L8O
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BU of 6l8o by Molmil
Crystal structure of the K. lactis Rad5 (Hg-derivative)
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA repair protein RAD5, MERCURY (II) ION
著者Shen, M, Xiang, S.
登録日2019-11-06
公開日2020-11-11
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural basis for the multi-activity factor Rad5 in replication stress tolerance.
Nat Commun, 12, 2021

 

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