8V52
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1AGQ
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6I9J
| Human transforming growth factor beta2 in a tetragonal crystal form | 分子名称: | Transforming growth factor beta-2 proprotein | 著者 | Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T. | 登録日 | 2018-11-23 | 公開日 | 2019-07-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation. Sci Rep, 9, 2019
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6XM2
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7ZJF
| R399E, a mutated form of GDF5, for disease modification of osteoarthritis | 分子名称: | Growth/differentiation factor 5 | 著者 | Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K. | 登録日 | 2022-04-10 | 公開日 | 2022-09-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis. Arthritis Rheumatol, 75, 2023
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7L0J
| Structure of AMH bound to AMHR2-ECD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ... | 著者 | Hart, K.N, Thompson, T.B. | 登録日 | 2020-12-11 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family. Proc.Natl.Acad.Sci.USA, 118, 2021
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5MR9
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6OMO
| Human BMP6 homodimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 6, ... | 著者 | Juo, Z.S, Seeherman, H. | 登録日 | 2019-04-19 | 公開日 | 2019-05-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med, 11, 2019
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1WAQ
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6OMN
| Glycosylated BMP2 homodimer | 分子名称: | Bone morphogenetic protein 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Juo, Z.S, Seeherman, H. | 登録日 | 2019-04-19 | 公開日 | 2019-05-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med, 11, 2019
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8E3G
| BMP2/GDF5 heterodimer | 分子名称: | Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5 | 著者 | Gipson, G.R, Nolan, K.T, Thompson, T.B. | 登録日 | 2022-08-17 | 公開日 | 2023-02-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers. Bmc Biol., 21, 2023
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5JI1
| Crystal Structure of GDF8 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Growth/differentiation factor 8 | 著者 | Walker, R.G, Thompson, T.B. | 登録日 | 2016-04-21 | 公開日 | 2017-03-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for potency differences between GDF8 and GDF11. BMC Biol., 15, 2017
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1BMP
| BONE MORPHOGENETIC PROTEIN-7 | 分子名称: | BONE MORPHOGENETIC PROTEIN-7 | 著者 | Griffith, D.L, Scott, D.L. | 登録日 | 1995-12-14 | 公開日 | 1997-07-23 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. Proc.Natl.Acad.Sci.USA, 93, 1996
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4KV5
| scFv GC1009 in complex with TGF-beta1. | 分子名称: | Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein | 著者 | Wei, R, Moulin, A.G, Mathieu, M. | 登録日 | 2013-05-22 | 公開日 | 2014-09-24 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23, 2014
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1ZKZ
| Crystal Structure of BMP9 | 分子名称: | Growth/differentiation factor 2 | 著者 | Brown, M.A, Zhao, Q, Baker, K.A, Naik, C, Chen, C, Pukac, L, Singh, M, Tsareva, T, Parice, Y, Mahoney, A, Roschke, V, Sanyal, I, Choe, S. | 登録日 | 2005-05-04 | 公開日 | 2005-05-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Crystal structure of BMP-9 and functional interactions with pro-region and receptors J.Biol.Chem., 280, 2005
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4KXZ
| crystal structure of tgfb2 in complex with GC2008. | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ... | 著者 | Mathieu, M, Moulin, A.G, Wei, R. | 登録日 | 2013-05-28 | 公開日 | 2014-09-24 | 最終更新日 | 2014-12-03 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23, 2014
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4MID
| Crystal Structure of Activin A/BMP2 chimera | 分子名称: | AB204 Activin A/BMP2 chimera | 著者 | Esquivies, L. | 登録日 | 2013-08-30 | 公開日 | 2014-05-07 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.139 Å) | 主引用文献 | An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2. J.Bone Miner.Res., 29, 2014
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4MPL
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5E4G
| Crystal structure of human growth differentiation factor 11 (GDF-11) | 分子名称: | Growth/differentiation factor 11, TETRAETHYLENE GLYCOL | 著者 | Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A. | 登録日 | 2015-10-06 | 公開日 | 2016-03-09 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of human GDF11. Acta Crystallogr.,Sect.F, 72, 2016
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5F3H
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5F3B
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4N1D
| Nodal/BMP2 chimera NB250 | 分子名称: | Nodal/BMP2 chimera protein | 著者 | Esquivies, L. | 登録日 | 2013-10-04 | 公開日 | 2013-12-04 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (1.912 Å) | 主引用文献 | Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure. J.Biol.Chem., 289, 2014
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3BMP
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3BK3
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8BWN
| Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation Factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4010 eV) | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-07 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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