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8V52
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Crystal structure of 2A10 Fab bound to Human TGF-beta3
分子名称: 2A10 Fab Heavy Chain, 2A10 Fab Light chain, Transforming growth factor beta-3
著者Yin, J, Lupardus, P.J.
登録日2023-11-30
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Isoform-selective TGF-beta 3 inhibition for systemic sclerosis.
Med, 5, 2024
1AGQ
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GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT
分子名称: GLIAL CELL-DERIVED NEUROTROPHIC FACTOR
著者Eigenbrot, C, Gerber, N.
登録日1997-03-25
公開日1997-06-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.
Nat.Struct.Biol., 4, 1997
6I9J
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Human transforming growth factor beta2 in a tetragonal crystal form
分子名称: Transforming growth factor beta-2 proprotein
著者Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T.
登録日2018-11-23
公開日2019-07-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation.
Sci Rep, 9, 2019
6XM2
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The structure of the 4A11.v7 antibody in complex with human TGFb2
分子名称: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2
著者Lupardus, P.J, Yin, J.P.
登録日2020-06-29
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis.
Sci Transl Med, 13, 2021
7ZJF
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R399E, a mutated form of GDF5, for disease modification of osteoarthritis
分子名称: Growth/differentiation factor 5
著者Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K.
登録日2022-04-10
公開日2022-09-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis.
Arthritis Rheumatol, 75, 2023
7L0J
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Structure of AMH bound to AMHR2-ECD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ...
著者Hart, K.N, Thompson, T.B.
登録日2020-12-11
公開日2021-06-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family.
Proc.Natl.Acad.Sci.USA, 118, 2021
5MR9
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Ligand-receptor complex.
分子名称: Neurturin
著者Sandmark, J, Oster, L, Aagaard, A, Roth, R.G, Dahl, G.
登録日2016-12-21
公開日2018-01-17
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure and biophysical characterisation of the human complex - a role for heparan sulfate
To Be Published
6OMO
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Human BMP6 homodimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 6, ...
著者Juo, Z.S, Seeherman, H.
登録日2019-04-19
公開日2019-05-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
1WAQ
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Crystal structure of human Growth and Differentiation Factor 5 (GDF-5)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GROWTH/DIFFERENTIATION FACTOR 5
著者Mueller, T.D, Nickel, J, Sebald, W.
登録日2004-10-27
公開日2005-05-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献A Single Residue of Gdf-5 Defines Binding Specificity to Bmp Receptor Ib.
J.Mol.Biol., 349, 2005
6OMN
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Glycosylated BMP2 homodimer
分子名称: Bone morphogenetic protein 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Juo, Z.S, Seeherman, H.
登録日2019-04-19
公開日2019-05-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
8E3G
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BMP2/GDF5 heterodimer
分子名称: Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5
著者Gipson, G.R, Nolan, K.T, Thompson, T.B.
登録日2022-08-17
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.
Bmc Biol., 21, 2023
5JI1
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BU of 5ji1 by Molmil
Crystal Structure of GDF8
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Growth/differentiation factor 8
著者Walker, R.G, Thompson, T.B.
登録日2016-04-21
公開日2017-03-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for potency differences between GDF8 and GDF11.
BMC Biol., 15, 2017
1BMP
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BONE MORPHOGENETIC PROTEIN-7
分子名称: BONE MORPHOGENETIC PROTEIN-7
著者Griffith, D.L, Scott, D.L.
登録日1995-12-14
公開日1997-07-23
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
Proc.Natl.Acad.Sci.USA, 93, 1996
4KV5
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BU of 4kv5 by Molmil
scFv GC1009 in complex with TGF-beta1.
分子名称: Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein
著者Wei, R, Moulin, A.G, Mathieu, M.
登録日2013-05-22
公開日2014-09-24
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
1ZKZ
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BU of 1zkz by Molmil
Crystal Structure of BMP9
分子名称: Growth/differentiation factor 2
著者Brown, M.A, Zhao, Q, Baker, K.A, Naik, C, Chen, C, Pukac, L, Singh, M, Tsareva, T, Parice, Y, Mahoney, A, Roschke, V, Sanyal, I, Choe, S.
登録日2005-05-04
公開日2005-05-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Crystal structure of BMP-9 and functional interactions with pro-region and receptors
J.Biol.Chem., 280, 2005
4KXZ
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crystal structure of tgfb2 in complex with GC2008.
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ...
著者Mathieu, M, Moulin, A.G, Wei, R.
登録日2013-05-28
公開日2014-09-24
最終更新日2014-12-03
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
4MID
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BU of 4mid by Molmil
Crystal Structure of Activin A/BMP2 chimera
分子名称: AB204 Activin A/BMP2 chimera
著者Esquivies, L.
登録日2013-08-30
公開日2014-05-07
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.139 Å)
主引用文献An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2.
J.Bone Miner.Res., 29, 2014
4MPL
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Crystal structure of BMP9 at 1.90 Angstrom
分子名称: Growth/differentiation factor 2
著者Li, W, Morrell, N.W, Wei, Z.
登録日2013-09-13
公開日2014-09-17
最終更新日2021-06-02
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis.
J.Biol.Chem., 289, 2014
5E4G
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BU of 5e4g by Molmil
Crystal structure of human growth differentiation factor 11 (GDF-11)
分子名称: Growth/differentiation factor 11, TETRAETHYLENE GLYCOL
著者Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A.
登録日2015-10-06
公開日2016-03-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of human GDF11.
Acta Crystallogr.,Sect.F, 72, 2016
5F3H
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Structure of myostatin in complex with humanized RK35 antibody
分子名称: Growth/differentiation factor 8, humanized RK35 antibody heavy chain, humanized RK35 antibody light chain
著者Parris, K.D, Mosyak, L.
登録日2015-12-02
公開日2016-09-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
5F3B
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Structure of myostatin in complex with chimeric RK35 antibody
分子名称: GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ...
著者Parris, K.D, Mosyak, L.
登録日2015-12-02
公開日2016-09-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
4N1D
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BU of 4n1d by Molmil
Nodal/BMP2 chimera NB250
分子名称: Nodal/BMP2 chimera protein
著者Esquivies, L.
登録日2013-10-04
公開日2013-12-04
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.912 Å)
主引用文献Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure.
J.Biol.Chem., 289, 2014
3BMP
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HUMAN BONE MORPHOGENETIC PROTEIN-2 (BMP-2)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEIN (BONE MORPHOGENETIC PROTEIN 2 (BMP-2))
著者Scheufler, C, Sebald, W, Huelsmeyer, M.
登録日1999-03-12
公開日2000-03-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution.
J.Mol.Biol., 287, 1999
3BK3
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Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2
分子名称: Bone morphogenetic protein 2, Crossveinless 2
著者Mueller, T.D, Sebald, W, Zhang, J.-L.
登録日2007-12-05
公開日2008-05-27
最終更新日2021-11-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding
Dev.Cell, 14, 2008
8BWN
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Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation Factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4010 eV)
分子名称: CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1
著者Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C.
登録日2022-12-07
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024

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