4MYG
| MAPK13, active form | 分子名称: | Mitogen-activated protein kinase 13 | 著者 | Yurtsever, Z, Brett, T.J, Scheaffer, S.M. | 登録日 | 2013-09-27 | 公開日 | 2015-03-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.594 Å) | 主引用文献 | The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation. Acta Crystallogr.,Sect.D, 71, 2015
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6SFO
| MAPK14 with bound inhibitor SR-318 | 分子名称: | 5-azanyl-~{N}-[[4-(3-cyclohexylpropylcarbamoyl)phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, GLYCEROL, Mitogen-activated protein kinase 14, ... | 著者 | Schroeder, M, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2019-08-01 | 公開日 | 2019-09-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | MAPK14 with bound inhibitor SR-318 To Be Published
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4EYM
| MAPK13 complex with inhibitor | 分子名称: | 2-(morpholin-4-yl)-N-[4-(pyridin-4-yloxy)phenyl]pyridine-4-carboxamide, Mitogen-activated protein kinase 13 | 著者 | Miller, C.A, Brett, T.J. | 登録日 | 2012-05-01 | 公開日 | 2012-12-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | 主引用文献 | IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. J.Clin.Invest., 122, 2012
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4EYJ
| MAPK13 Complex with inhibitor | 分子名称: | 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-[4-(pyridin-4-yloxy)phenyl]urea, Mitogen-activated protein kinase 13 | 著者 | Miller, C.A, Brett, T.J. | 登録日 | 2012-05-01 | 公開日 | 2012-12-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. J.Clin.Invest., 122, 2012
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5EKN
| Crystal structure of MAPK13 complex with inhibitor | 分子名称: | 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-[4-(pyridin-4-ylsulfanyl)phenyl]urea, Mitogen-activated protein kinase 13 | 著者 | Brett, T.J, Miller, C.A, Yurtsever, Z. | 登録日 | 2015-11-03 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.594 Å) | 主引用文献 | First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochim.Biophys.Acta, 1860, 2016
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5EKO
| Crystal structure of MAPK13 complex with inhibitor | 分子名称: | 3-(4-methyl-1H-imidazol-1-yl)-N-[4-(pyridin-4-yloxy)phenyl]benzamide, Mitogen-activated protein kinase 13 | 著者 | Brett, T.J, Miller, C.A, Yurtsever, Z. | 登録日 | 2015-11-03 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochim.Biophys.Acta, 1860, 2016
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4YNO
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8YGW
| The Crystal Structure of MAPK11 from Biortus | 分子名称: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Mitogen-activated protein kinase 11 | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. | 登録日 | 2024-02-27 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.301 Å) | 主引用文献 | The Crystal Structure of MAPK11 from Biortus. To Be Published
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8X23
| The Crystal Structure of MAPK13 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Mitogen-activated protein kinase 13 | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Pan, W. | 登録日 | 2023-11-09 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The Crystal Structure of MAPK13 from Biortus. To Be Published
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5ETA
| Structure of MAPK14 with bound the KIM domain of the Toxoplasma protein GRA24 | 分子名称: | Mitogen-activated protein kinase 14, Putative transmembrane protein | 著者 | Pellegrini, E, Palencia, A, Braun, L, Kapp, U, Bougdour, A, Belrhali, H, Bowler, M.W, Hakimi, M. | 登録日 | 2015-11-17 | 公開日 | 2016-10-26 | 最終更新日 | 2019-02-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist. Structure, 25, 2017
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5ETF
| Structure of dead kinase MAPK14 with bound the KIM domain of MKK6 | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase 14 | 著者 | Pellegrini, E, Palencia, A, Braun, L, Kapp, U, Bougdour, A, Belrhali, H, Bowler, M.W, Hakimi, M. | 登録日 | 2015-11-17 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist. Structure, 25, 2017
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4QUM
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7BDQ
| MAPK14 bound with SR300 | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 14, ... | 著者 | Schroeder, M, Roehm, S, Joerger, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-12-22 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J.Med.Chem., 64, 2021
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7BDO
| MAPK14 bound with SR302 | 分子名称: | Mitogen-activated protein kinase 14, ~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{S})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide | 著者 | Schroeder, M, Roehm, S, Joerger, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-12-22 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J.Med.Chem., 64, 2021
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6G54
| Crystal structure of ERK2 covalently bound to SM1-71 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Mitogen-activated protein kinase 1, ... | 著者 | Chaikuad, A, Suman, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2018-03-29 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol, 26, 2019
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5ETI
| Structure of dead kinase MAPK14 | 分子名称: | Mitogen-activated protein kinase 14 | 著者 | Pellegrini, E, Bowler, M.W. | 登録日 | 2015-11-17 | 公開日 | 2016-01-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation. Science, 381, 2023
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5ETC
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5LAR
| Crystal structure of p38 alpha MAPK14 in complex with VPC00628 | 分子名称: | 5-azanyl-~{N}-[[4-[[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Chaikuad, A, Petersen, L.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-14 | 公開日 | 2016-07-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Novel p38alpha MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library Medchemcomm, 7, 2016
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5NZZ
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4QUN
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8CPD
| Cryo-EM structure of CRaf dimer with 14:3:3 | 分子名称: | 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase | 著者 | Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J. | 登録日 | 2023-03-02 | 公開日 | 2024-02-21 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
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3KN6
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8CHF
| cryo-EM Structure of Craf:14-3-3:Mek1 | 分子名称: | 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Dedden, D, Ulrich, G. | 登録日 | 2023-02-07 | 公開日 | 2024-02-21 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
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7Z38
| Structure of the RAF1-HSP90-CDC37 complex (RHC-I) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... | 著者 | Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G. | 登録日 | 2022-03-01 | 公開日 | 2022-09-14 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol.Cell, 82, 2022
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7Z37
| Structure of the RAF1-HSP90-CDC37 complex (RHC-II) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... | 著者 | Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G. | 登録日 | 2022-03-01 | 公開日 | 2022-09-14 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | 主引用文献 | Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol.Cell, 82, 2022
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