5NZZ

Crystal structure of phosphorylated p38aMAPK in complex with TAB1

Summary for 5NZZ

Entry DOI	10.2210/pdb5nzz/pdb
Descriptor	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase 14, NICKEL (II) ION, ... (6 entities in total)
Functional Keywords	mapk activated phosphorylated p38 regulation, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	387382.88
Authors	Nichols, C.E.,De Nicola, G.F. (deposition date: 2017-05-15, release date: 2018-05-30, Last modification date: 2018-09-19)
Primary citation	De Nicola, G.F.,Bassi, R.,Nichols, C.,Fernandez-Caggiano, M.,Golforoush, P.A.,Thapa, D.,Anderson, R.,Martin, E.D.,Verma, S.,Kleinjung, J.,Laing, A.,Hutchinson, J.P.,Eaton, P.,Clark, J.,Marber, M.S. The TAB1-p38 alpha complex aggravates myocardial injury and can be targeted by small molecules. JCI Insight, 3:-, 2018 Cited by PubMed: 30135318 DOI: 10.1172/jci.insight.121144 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation