6G54
Crystal structure of ERK2 covalently bound to SM1-71
Summary for 6G54
Entry DOI | 10.2210/pdb6g54/pdb |
Descriptor | Mitogen-activated protein kinase 1, SULFATE ION, N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide, ... (6 entities in total) |
Functional Keywords | kinase, covalent inhibitor, mapk, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43032.17 |
Authors | Chaikuad, A.,Suman, R.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gray, N.S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-03-29, release date: 2019-02-27, Last modification date: 2024-01-17) |
Primary citation | Rao, S.,Gurbani, D.,Du, G.,Everley, R.A.,Browne, C.M.,Chaikuad, A.,Tan, L.,Schroder, M.,Gondi, S.,Ficarro, S.B.,Sim, T.,Kim, N.D.,Berberich, M.J.,Knapp, S.,Marto, J.A.,Westover, K.D.,Sorger, P.K.,Gray, N.S. Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol, 26:818-, 2019 Cited by PubMed: 30982749DOI: 10.1016/j.chembiol.2019.02.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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