4EYJ

MAPK13 Complex with inhibitor

Summary for 4EYJ

Entry DOI	10.2210/pdb4eyj/pdb
Related	4EXU 4EYM
Descriptor	Mitogen-activated protein kinase 13, 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-[4-(pyridin-4-yloxy)phenyl]urea (3 entities in total)
Functional Keywords	p38 family kinase, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42999.33
Authors	Miller, C.A.,Brett, T.J. (deposition date: 2012-05-01, release date: 2012-12-19, Last modification date: 2023-09-13)
Primary citation	Alevy, Y.G.,Patel, A.C.,Romero, A.G.,Patel, D.A.,Tucker, J.,Roswit, W.T.,Miller, C.A.,Heier, R.F.,Byers, D.E.,Brett, T.J.,Holtzman, M.J. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. J.Clin.Invest., 122:4555-4568, 2012 Cited by PubMed: 23187130 DOI: 10.1172/JCI64896 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.102 Å)

Structure validation