7JVB
 
 | Crystal structure of the SARS-CoV-2 spike receptor-binding domain (RBD) with nanobody Nb20 | 分子名称: | CACODYLATE ION, Nanobody Nb20, Spike protein S1 | 著者 | Xiang, Y, Xiao, Z, Liu, H, Sang, Z, Schneidman-Duhovny, D, Zhang, C, Shi, Y. | 登録日 | 2020-08-20 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (3.287 Å) | 主引用文献 | Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2. Science, 370, 2020
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7KFV
 
 | Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B12 Fab) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody C1A-B12 Fab, Spike glycoprotein, ... | 著者 | Pan, J, Abraham, J, Clark, L, Clark, S. | 登録日 | 2020-10-15 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. Biorxiv, 2020
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7KFW
 
 | Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B3 Fab) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of antibody C1A-B3 Fab, ... | 著者 | Pan, J, Abraham, J, Clark, L, Clark, S. | 登録日 | 2020-10-15 | 公開日 | 2020-12-02 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.792 Å) | 主引用文献 | Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. Biorxiv, 2020
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7KFX
 
 | Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-C2 Fab) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of human antibody C1A-C2 Fab, ... | 著者 | Pan, J, Abraham, J, Clark, L, Clark, S. | 登録日 | 2020-10-15 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | 主引用文献 | Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. Biorxiv, 2020
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7KFY
 
 | Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-F10 Fab) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of human antibody C1A-F10 Fab, ... | 著者 | Pan, J, Abraham, J, Clark, L, Clark, S. | 登録日 | 2020-10-15 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.157 Å) | 主引用文献 | Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. Biorxiv, 2020
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7CYQ
 
 | Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... | 著者 | Yan, L, Ge, J, Zheng, L, Zhang, Y, Gao, Y, Wang, T, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | 登録日 | 2020-09-04 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell, 184, 2021
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7K0R
 
 | Nucleotide bound SARS-CoV-2 Nsp15 | 分子名称: | PHOSPHATE ION, URIDINE-5'-MONOPHOSPHATE, Uridylate-specific endoribonuclease | 著者 | Pillon, M.C, Stanley, R.E. | 登録日 | 2020-09-04 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun, 12, 2021
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7KMB
 
 | ACE2-RBD Focused Refinement Using Symmetry Expansion of Applied C3 for Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Gorman, J, Kwong, P.D, Shapiro, L. | 登録日 | 2020-11-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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7KMS
 
 | Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Gorman, J, Kwong, P.D, Shapiro, L. | 登録日 | 2020-11-03 | 公開日 | 2020-12-09 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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7KMZ
 
 | Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Gorman, J, Kwong, P.D, Shapiro, L. | 登録日 | 2020-11-03 | 公開日 | 2020-12-09 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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7KR0
 
 | Crystal structure of SARS-CoV-2 NSP3 macrodomain (C2 crystal form, 100 K) | 分子名称: | Non-structural protein 3 | 著者 | Correy, G.J, Young, I.D, Thompson, M.C, Fraser, J.S. | 登録日 | 2020-11-18 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (0.77 Å) | 主引用文献 | Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci Adv, 7, 2021
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7B3O
 
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7CAB
 
 | Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhe, L, Cao, L, Deng, Y, Sun, Y, Wang, N, Xie, L, Wang, Y, Rao, Z, Qin, C, Wang, X. | 登録日 | 2020-06-08 | 公開日 | 2020-12-16 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. Science, 369, 2020
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7CWM
 
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7CWN
 
 | P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Wang, N, Wang, X. | 登録日 | 2020-08-29 | 公開日 | 2020-12-16 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection. Cell Res., 31, 2021
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7CWS
 
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7CWU
 
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7DF3
 
 | SARS-CoV-2 S trimer, S-closed | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cong, X, Yao, C. | 登録日 | 2020-11-06 | 公開日 | 2020-12-16 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv, 7, 2021
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7DF4
 
 | SARS-CoV-2 S-ACE2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Cong, X, Yao, C. | 登録日 | 2020-11-06 | 公開日 | 2020-12-16 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv, 7, 2021
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6ZLR
 
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7B3B
 
 | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1) | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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7B3C
 
 | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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7B3D
 
 | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with AMP at position -4 (structure 3) | 分子名称: | RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase nsp12, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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7DMU
 
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7L09
 
 | Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound domain-swapped antibody 2G12 from masked 3D refinement | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2G12 heavy chain, ... | 著者 | Manne, K, Henderson, R, Acharya, P. | 登録日 | 2020-12-11 | 公開日 | 2020-12-30 | 最終更新日 | 2024-11-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021
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