7DMU

Structure of SARS-CoV-2 spike receptor-binding domain complexed with high affinity ACE2 mutant 3N39

Summary for 7DMU

• Entry DOI: 10.2210/pdb7dmu/pdb
• Descriptor: Angiotensin-converting enzyme 2, Spike protein S1, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: sars-cov-2, covid-19, ace2, viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 196426.79

Authors

Arimori, T.,Takagi, J. (deposition date: 2020-12-07, release date: 2020-12-23, Last modification date: 2023-11-29)

• Primary citation: Higuchi, Y.,Suzuki, T.,Arimori, T.,Ikemura, N.,Mihara, E.,Kirita, Y.,Ohgitani, E.,Mazda, O.,Motooka, D.,Nakamura, S.,Sakai, Y.,Itoh, Y.,Sugihara, F.,Matsuura, Y.,Matoba, S.,Okamoto, T.,Takagi, J.,Hoshino, A.; Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.; Nat Commun, 12:3802-3802, 2021; PubMed: 34155214; DOI: 10.1038/s41467-021-24013-y

Experimental method

X-RAY DIFFRACTION (3.2 Å)