[English] 日本語
Yorodumi- PDB-1ikf: A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED B... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1ikf | ||||||
---|---|---|---|---|---|---|---|
Title | A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX | ||||||
Components |
| ||||||
Keywords | IMMUNE SYSTEM/IMMUNOSUPPRESSANT / IMMUNE SYSTEM-IMMUNOSUPPRESSANT COMPLEX / FAB-CYCLOSPORIN COMPLEX / CYCLOSPORIN A / IMMUNOSUPPRESSANT | ||||||
Function / homology | Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta / Cyclosporin A / : Function and homology information | ||||||
Biological species | HOMO SAPIENS (human) TOLYPOCLADIUM INFLATUM (fungus) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 2.5 Å | ||||||
Authors | Vix, O. / Altschuh, D. / Rees, B. / Thierry, J.-C. | ||||||
Citation | Journal: Science / Year: 1992 Title: A Conformation of Cyclosporin a in Aqueous Environment Revealed by the X-Ray Structure of a Cyclosporin-Fab Complex. Authors: Altschuh, D. / Vix, O. / Rees, B. / Thierry, J.C. #1: Journal: Proteins / Year: 1993 Title: Crystallographic Analysis of the Interaction between Cyclosporin a and the Fab Fragment of a Monoclonal Antibody. Authors: Vix, O. / Rees, B. / Thierry, J.C. / Altschuh, D. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 1ikf.cif.gz | 103.8 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb1ikf.ent.gz | 79 KB | Display | PDB format |
PDBx/mmJSON format | 1ikf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1ikf_validation.pdf.gz | 444 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 1ikf_full_validation.pdf.gz | 460.3 KB | Display | |
Data in XML | 1ikf_validation.xml.gz | 22.5 KB | Display | |
Data in CIF | 1ikf_validation.cif.gz | 30.9 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ik/1ikf ftp://data.pdbj.org/pub/pdb/validation_reports/ik/1ikf | HTTPS FTP |
-Related structure data
Related structure data | |
---|---|
Similar structure data |
-Links
-Assembly
Deposited unit |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||
Unit cell |
| ||||||||
Atom site foot note | 1: CIS PROLINE - PRO L 95 / 2: CIS PROLINE - PRO L 141 / 3: CIS PROLINE - PRO H 160 / 4: CIS PROLINE - PRO H 162 / 5: CIS PROLINE - PRO H 202 |
-Components
#1: Antibody | Mass: 23549.000 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) HOMO SAPIENS (human) |
---|---|
#2: Antibody | Mass: 24777.887 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) HOMO SAPIENS (human) |
#3: Protein/peptide | Type: Cyclic peptide / Class: Immunosuppressant / Mass: 1220.625 Da / Num. of mol.: 1 / Source method: obtained synthetically Details: CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE. CYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI. Source: (synth.) TOLYPOCLADIUM INFLATUM (fungus) / References: NOR: NOR00033, Cyclosporin A |
#4: Water | ChemComp-HOH / |
Compound details | CYCLOSPORI |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
---|
-Sample preparation
Crystal | Density Matthews: 2.2 Å3/Da / Density % sol: 44.22 % |
---|---|
Crystal grow | *PLUS Method: unknown |
-Data collection
Radiation | Scattering type: x-ray |
---|---|
Radiation wavelength | Relative weight: 1 |
Reflection | *PLUS Highest resolution: 2.6 Å / Num. obs: 14219 / Num. measured all: 63899 / Rmerge(I) obs: 0.087 |
-Processing
Software |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Resolution: 2.5→8 Å / Rfactor Rwork: 0.164 / Rfactor obs: 0.164 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.5→8 Å
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Num. reflection obs: 11236 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS |