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Yorodumi- PDB-3cys: DETERMINATION OF THE NMR SOLUTION STRUCTURE OF THE CYCLOPHILIN A-... -
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-Basic information
Entry | Database: PDB / ID: 3cys | |||||||||
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Title | DETERMINATION OF THE NMR SOLUTION STRUCTURE OF THE CYCLOPHILIN A-CYCLOSPORIN A COMPLEX | |||||||||
Components |
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Keywords | ISOMERASE/IMMUNOSUPPRESSANT / ISOMERASE-IMMUNOSUPPRESSANT COMPLEX / CYCLOPHILIN-CYCLOSPORIN COMPLEX / CYCLOSPORIN A / IMMUNOSUPPRESSANT / CYCLOPHILIN | |||||||||
Function / homology | Function and homology information negative regulation of protein K48-linked ubiquitination / negative regulation of viral life cycle / regulation of apoptotic signaling pathway / cell adhesion molecule production / lipid droplet organization / heparan sulfate binding / regulation of viral genome replication / leukocyte chemotaxis / endothelial cell activation / virion binding ...negative regulation of protein K48-linked ubiquitination / negative regulation of viral life cycle / regulation of apoptotic signaling pathway / cell adhesion molecule production / lipid droplet organization / heparan sulfate binding / regulation of viral genome replication / leukocyte chemotaxis / endothelial cell activation / virion binding / Basigin interactions / negative regulation of stress-activated MAPK cascade / cyclosporin A binding / Minus-strand DNA synthesis / Plus-strand DNA synthesis / Uncoating of the HIV Virion / Early Phase of HIV Life Cycle / Integration of provirus / APOBEC3G mediated resistance to HIV-1 infection / Calcineurin activates NFAT / viral release from host cell / positive regulation of viral genome replication / Binding and entry of HIV virion / protein peptidyl-prolyl isomerization / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of protein dephosphorylation / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / activation of protein kinase B activity / neutrophil chemotaxis / negative regulation of protein phosphorylation / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / positive regulation of protein secretion / Assembly Of The HIV Virion / negative regulation of protein kinase activity / Budding and maturation of HIV virion / neuron differentiation / platelet activation / platelet aggregation / SARS-CoV-1 activates/modulates innate immune responses / unfolded protein binding / integrin binding / protein folding / Platelet degranulation / positive regulation of NF-kappaB transcription factor activity / cellular response to oxidative stress / secretory granule lumen / vesicle / ficolin-1-rich granule lumen / positive regulation of MAPK cascade / response to hypoxia / positive regulation of protein phosphorylation / intracellular membrane-bounded organelle / focal adhesion / apoptotic process / Neutrophil degranulation / protein-containing complex / RNA binding / extracellular space / extracellular exosome / extracellular region / membrane / nucleus / cytoplasm / cytosol Similarity search - Function | |||||||||
Biological species | HOMO SAPIENS (human) TOLYPOCLADIUM INFLATUM (fungus) | |||||||||
Method | SOLUTION NMR | |||||||||
Authors | Spitzfaden, C. / Braun, W. / Wider, G. / Widmer, H. / Wuthrich, K. | |||||||||
Citation | Journal: J.Biomol.NMR / Year: 1994 Title: Determination of the NMR Solution Structure of the Cyclophilin A-Cyclosporin a Complex. Authors: Spitzfaden, C. / Braun, W. / Wider, G. / Widmer, H. / Wuthrich, K. #1: Journal: Biochemistry / Year: 1991 Title: The NMR Structure of Cyclosporin a Bound to Cyclophilin in Aqueous Solution. Authors: Weber, C. / Wider, G. / Von Freyberg, B. / Traber, R. / Braun, W. / Widmer, H. / Wuthrich, K. #2: Journal: Science / Year: 1991 Title: Receptor-Induced Conformation Change of the Immunosuppressant Cyclosporin A. Authors: Wuthrich, K. / Von Freyberg, B. / Weber, C. / Wider, G. / Traber, R. / Widmer, H. / Braun, W. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3cys.cif.gz | 1.2 MB | Display | PDBx/mmCIF format |
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PDB format | pdb3cys.ent.gz | 1.1 MB | Display | PDB format |
PDBx/mmJSON format | 3cys.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3cys_validation.pdf.gz | 356.6 KB | Display | wwPDB validaton report |
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Full document | 3cys_full_validation.pdf.gz | 515.1 KB | Display | |
Data in XML | 3cys_validation.xml.gz | 105.9 KB | Display | |
Data in CIF | 3cys_validation.cif.gz | 115.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/cy/3cys ftp://data.pdbj.org/pub/pdb/validation_reports/cy/3cys | HTTPS FTP |
-Related structure data
Related structure data | |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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1 |
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Atom site foot note | 1: RESIDUE ALA B 208 IS A D-ALANINE. MODEL | |||||||||
NMR ensembles |
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-Components
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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-Processing
NMR software | Name: DIANA, FANTOM 3.1 Developer: GUNTERT,BRAUN,WUTHRICH (DIANA), VON FREYBERG, SCHAUMANN,BRAUN (FANTOM) Classification: refinement |
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NMR ensemble | Conformers submitted total number: 22 |