Author results

3HHR
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HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
Descriptor:HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
Authors:De Vos, A.M., Ultsch, M., Kossiakoff, A.A.
Deposit date:1993-12-30
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
1TPK
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CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
Descriptor:TISSUE PLASMINOGEN ACTIVATOR, CHLORIDE ION
Authors:De vos, A.M., Ultsch, M.H., Kelley, R.F., Padmanabhan, K., Tulinsky, A., Westbrook, M.L., Kossiakoff, A.A.
Deposit date:1991-09-24
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
1A22
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HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
Descriptor:GROWTH HORMONE, GROWTH HORMONE RECEPTOR
Authors:De Vos, A.M., Ultsch, M.
Deposit date:1998-01-15
Release date:1998-04-29
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
2VPF
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VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1997-07-29
Release date:1998-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
1S78
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INSIGHTS INTO ERBB SIGNALING FROM THE STRUCTURE OF THE ERBB2-PERTUZUMAB COMPLEX
Descriptor:Receptor protein-tyrosine kinase erbB-2, Pertuzumab Fab light chain, Pertuzumab Fab heavy chain, ...
Authors:Franklin, M.C., Carey, K.D., Vajdos, F.F., Leahy, D.J., de Vos, A.M., Sliwkowski, M.X.
Deposit date:2004-01-29
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Cancer Cell, 5, 2004
1AXI
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STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor:GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
Authors:Atwell, S., Ultsch, M., De Vos, A.M., Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1F6F
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR
Descriptor:PLACENTAL LACTOGEN, PROLACTIN RECEPTOR
Authors:Elkins, P.A., Christinger, H.W., Sandowski, Y., Sakal, E., Gertler, A., De Vos, A.M., Kossiakoff, A.A.
Deposit date:2000-06-21
Release date:2000-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
1QTY
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR, FMS-LIKE TYROSINE KINASE 1
Authors:Wiesmann, C., de Vos, A.M.
Deposit date:1999-06-29
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
1RV6
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CRYSTAL STRUCTURE OF PLGF IN COMPLEX WITH DOMAIN 2 OF VEGFR1
Descriptor:placenta growth factor (PlGF), FLT1 protein, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Christinger, H.W., Fuh, G., de Vos, A.M., Wiesmann, C.
Deposit date:2003-12-12
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
1VPF
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STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1997-04-08
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
Proc.Natl.Acad.Sci.USA, 94, 1997
2HFT
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THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN TISSUE FACTOR AT 1.7 ANGSTROMS RESOLUTION
Descriptor:HUMAN TISSUE FACTOR, SULFATE ION
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1995-09-08
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:The crystal structure of the extracellular domain of human tissue factor refined to 1.7 A resolution.
J.Mol.Biol., 256, 1996
1CZ8
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Descriptor:Vascular endothelial growth factor A, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, HEAVY CHAIN OF NEUTRALIZING ANTIBODY, ...
Authors:Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B.
Deposit date:1999-09-01
Release date:2000-03-20
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
1M1L
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HUMAN SUPPRESSOR OF FUSED (N-TERMINAL DOMAIN)
Descriptor:Suppressor of Fused
Authors:Merchant, M., Vajdos, F.F., Ultsch, M., Maun, H.R., Wendt, U., Cannon, J., Lazarus, R.A., de Vos, A.M., de Sauvage, F.J.
Deposit date:2002-06-19
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Suppressor of fused regulates Gli activity through a dual binding mechanism
Mol.Cell.Biol., 24, 2004
1A21
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TISSUE FACTOR (TF) FROM RABBIT
Descriptor:TISSUE FACTOR
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1998-01-14
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Hinge bending within the cytokine receptor superfamily revealed by the 2.4 A crystal structure of the extracellular domain of rabbit tissue factor.
Protein Sci., 7, 1998
1BHT
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NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR
Descriptor:HEPATOCYTE GROWTH FACTOR, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Ultsch, M.H., Lokker, N.A., Godowski, P.J., De Vos, A.M.
Deposit date:1998-06-10
Release date:1998-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.
Structure, 6, 1998
1BJ1
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
Descriptor:Fab fragment, light chain, heavy chain, ...
Authors:Muller, Y.A., Christinger, H.W., De Vos, A.M.
Deposit date:1998-06-30
Release date:1999-01-13
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
1BP3
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THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Descriptor:PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION
Authors:Somers, W., Ultsch, M., De Vos, A.M., Kossiakoff, A.A.
Deposit date:1998-08-12
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
1D0G
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CRYSTAL STRUCTURE OF DEATH RECEPTOR 5 (DR5) BOUND TO APO2L/TRAIL
Descriptor:DEATH RECEPTOR-5, APOPTOSIS-2 LIGAND, ZINC ION, ...
Authors:Hymowitz, S.G., Christinger, H.W., Fuh, G., O'Connell, M.P., Kelley, R.F., Ashkenazi, A., de Vos, A.M.
Deposit date:1999-09-09
Release date:1999-10-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
Mol.Cell, 4, 1999
1DG6
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CRYSTAL STRUCTURE OF APO2L/TRAIL
Descriptor:APO2L/TNF-RELATED APOPOTIS INDUCING LIGAND (TRAIL), ZINC ION, CHLORIDE ION
Authors:Hymowitz, S.G., O'ConnelL, M.P., Ultsch, M.H., de Vos, A.M., Kelley, R.F.
Deposit date:1999-11-23
Release date:2000-01-26
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Biochemistry, 39, 2000
1DN2
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FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2
Descriptor:IMMUNOGLOBULIN LAMBDA HEAVY CHAIN, ENGINEERED PEPTIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:DeLano, W.L., Ultsch, M.H., de Vos, A.M., Wells, J.A.
Deposit date:1999-12-15
Release date:2000-05-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Convergent solutions to binding at a protein-protein interface.
Science, 287, 2000
1FLT
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VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR, FMS-LIKE TYROSINE KINASE 1
Authors:Wiesmann, C., De Vos, A.M.
Deposit date:1997-11-20
Release date:1999-01-13
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
1HUW
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THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
Descriptor:HUMAN GROWTH HORMONE
Authors:Ultsch, M.H., Somers, W.S., Kossiakoff, A.A., De Vos, A.M.
Deposit date:1993-09-22
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
1IMX
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1.8 ANGSTROM CRYSTAL STRUCTURE OF IGF-1
Descriptor:Insulin-like Growth Factor 1A, BROMIDE ION, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE
Authors:Vajdos, F.F., Ultsch, M., Schaffer, M.L., Deshayes, K.D., Liu, J., Skelton, N.J., de Vos, A.M.
Deposit date:2001-05-11
Release date:2001-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.
Biochemistry, 40, 2001
1JPY
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CRYSTAL STRUCTURE OF IL-17F
Descriptor:interleukin 17F, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hymowitz, S.G., Filvaroff, E.H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R., Pan, G., Gurney, A.L., de Vos, A.M., Starovasnik, M.A.
Deposit date:2001-08-03
Release date:2001-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20, 2001
1KF9
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PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Descriptor:PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238)
Authors:Schiffer, C.A., Ultsch, M., Walsh, S., Somers, W., De Vos, A.M., Kossiakoff, A.A.
Deposit date:2001-11-19
Release date:2002-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
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