Author results

3HHR
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HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
分子名称:HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
著者De Vos, A.M., Ultsch, M., Kossiakoff, A.A.
登録日1993-12-30
公開日1994-04-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
1TPK
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CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
分子名称:TISSUE PLASMINOGEN ACTIVATOR, CHLORIDE ION
著者De vos, A.M., Ultsch, M.H., Kelley, R.F., Padmanabhan, K., Tulinsky, A., Westbrook, M.L., Kossiakoff, A.A.
登録日1991-09-24
公開日1992-07-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
1A22
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HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
分子名称:GROWTH HORMONE, GROWTH HORMONE RECEPTOR
著者De Vos, A.M., Ultsch, M.
登録日1998-01-15
公開日1998-04-29
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
2VPF
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VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Muller, Y.A., De Vos, A.M.
登録日1997-07-29
公開日1998-07-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
1S78
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INSIGHTS INTO ERBB SIGNALING FROM THE STRUCTURE OF THE ERBB2-PERTUZUMAB COMPLEX
分子名称:Receptor protein-tyrosine kinase erbB-2, Pertuzumab Fab light chain, Pertuzumab Fab heavy chain, ...
著者Franklin, M.C., Carey, K.D., Vajdos, F.F., Leahy, D.J., de Vos, A.M., Sliwkowski, M.X.
登録日2004-01-29
公開日2004-04-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Cancer Cell, 5, 2004
1AXI
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STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
分子名称:GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
著者Atwell, S., Ultsch, M., De Vos, A.M., Wells, J.A.
登録日1997-10-15
公開日1998-01-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1F6F
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR
分子名称:PLACENTAL LACTOGEN, PROLACTIN RECEPTOR
著者Elkins, P.A., Christinger, H.W., Sandowski, Y., Sakal, E., Gertler, A., De Vos, A.M., Kossiakoff, A.A.
登録日2000-06-21
公開日2000-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
1QTY
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR, FMS-LIKE TYROSINE KINASE 1
著者Wiesmann, C., de Vos, A.M.
登録日1999-06-29
公開日2000-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
1RV6
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CRYSTAL STRUCTURE OF PLGF IN COMPLEX WITH DOMAIN 2 OF VEGFR1
分子名称:placenta growth factor (PlGF), FLT1 protein, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Christinger, H.W., Fuh, G., de Vos, A.M., Wiesmann, C.
登録日2003-12-12
公開日2004-01-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
1VPF
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STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Muller, Y.A., De Vos, A.M.
登録日1997-04-08
公開日1998-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
Proc.Natl.Acad.Sci.USA, 94, 1997
2HFT
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THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN TISSUE FACTOR AT 1.7 ANGSTROMS RESOLUTION
分子名称:HUMAN TISSUE FACTOR, SULFATE ION
著者Muller, Y.A., De Vos, A.M.
登録日1995-09-08
公開日1996-01-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献The crystal structure of the extracellular domain of human tissue factor refined to 1.7 A resolution.
J.Mol.Biol., 256, 1996
1CZ8
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
分子名称:Vascular endothelial growth factor A, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, HEAVY CHAIN OF NEUTRALIZING ANTIBODY, ...
著者Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B.
登録日1999-09-01
公開日2000-03-20
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
1M1L
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HUMAN SUPPRESSOR OF FUSED (N-TERMINAL DOMAIN)
分子名称:Suppressor of Fused
著者Merchant, M., Vajdos, F.F., Ultsch, M., Maun, H.R., Wendt, U., Cannon, J., Lazarus, R.A., de Vos, A.M., de Sauvage, F.J.
登録日2002-06-19
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Suppressor of fused regulates Gli activity through a dual binding mechanism
Mol.Cell.Biol., 24, 2004
1A21
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TISSUE FACTOR (TF) FROM RABBIT
分子名称:TISSUE FACTOR
著者Muller, Y.A., De Vos, A.M.
登録日1998-01-14
公開日1998-05-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Hinge bending within the cytokine receptor superfamily revealed by the 2.4 A crystal structure of the extracellular domain of rabbit tissue factor.
Protein Sci., 7, 1998
1BHT
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NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR
分子名称:HEPATOCYTE GROWTH FACTOR, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
著者Ultsch, M.H., Lokker, N.A., Godowski, P.J., De Vos, A.M.
登録日1998-06-10
公開日1998-11-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.
Structure, 6, 1998
1BJ1
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
分子名称:Fab fragment, light chain, heavy chain, ...
著者Muller, Y.A., Christinger, H.W., De Vos, A.M.
登録日1998-06-30
公開日1999-01-13
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
1BP3
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THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
分子名称:PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION
著者Somers, W., Ultsch, M., De Vos, A.M., Kossiakoff, A.A.
登録日1998-08-12
公開日1998-08-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
1D0G
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CRYSTAL STRUCTURE OF DEATH RECEPTOR 5 (DR5) BOUND TO APO2L/TRAIL
分子名称:DEATH RECEPTOR-5, APOPTOSIS-2 LIGAND, ZINC ION, ...
著者Hymowitz, S.G., Christinger, H.W., Fuh, G., O'Connell, M.P., Kelley, R.F., Ashkenazi, A., de Vos, A.M.
登録日1999-09-09
公開日1999-10-22
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
Mol.Cell, 4, 1999
1DG6
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CRYSTAL STRUCTURE OF APO2L/TRAIL
分子名称:APO2L/TNF-RELATED APOPOTIS INDUCING LIGAND (TRAIL), ZINC ION, CHLORIDE ION
著者Hymowitz, S.G., O'ConnelL, M.P., Ultsch, M.H., de Vos, A.M., Kelley, R.F.
登録日1999-11-23
公開日2000-01-26
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Biochemistry, 39, 2000
1DN2
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FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2
分子名称:IMMUNOGLOBULIN LAMBDA HEAVY CHAIN, ENGINEERED PEPTIDE, N-ACETYL-D-GLUCOSAMINE, ...
著者DeLano, W.L., Ultsch, M.H., de Vos, A.M., Wells, J.A.
登録日1999-12-15
公開日2000-05-17
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Convergent solutions to binding at a protein-protein interface.
Science, 287, 2000
1FLT
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VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR, FMS-LIKE TYROSINE KINASE 1
著者Wiesmann, C., De Vos, A.M.
登録日1997-11-20
公開日1999-01-13
最終更新日2012-05-02
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
1HUW
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THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
分子名称:HUMAN GROWTH HORMONE
著者Ultsch, M.H., Somers, W.S., Kossiakoff, A.A., De Vos, A.M.
登録日1993-09-22
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
1IMX
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1.8 ANGSTROM CRYSTAL STRUCTURE OF IGF-1
分子名称:Insulin-like Growth Factor 1A, BROMIDE ION, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE
著者Vajdos, F.F., Ultsch, M., Schaffer, M.L., Deshayes, K.D., Liu, J., Skelton, N.J., de Vos, A.M.
登録日2001-05-11
公開日2001-09-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.
Biochemistry, 40, 2001
1JPY
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CRYSTAL STRUCTURE OF IL-17F
分子名称:interleukin 17F, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
著者Hymowitz, S.G., Filvaroff, E.H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R., Pan, G., Gurney, A.L., de Vos, A.M., Starovasnik, M.A.
登録日2001-08-03
公開日2001-09-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20, 2001
1KF9
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PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
分子名称:PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238)
著者Schiffer, C.A., Ultsch, M., Walsh, S., Somers, W., De Vos, A.M., Kossiakoff, A.A.
登録日2001-11-19
公開日2002-11-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
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