Author results

1SZC
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STRUCTURAL BASIS FOR NICOTINAMIDE CLEAVAGE AND ADP-RIBOSE TRANSFER BY NAD+-DEPENDENT SIR2 HISTONE/PROTEIN DEACETYLASES
Descriptor:NAD-dependent deacetylase HST2, Histone H4 peptide, ZINC ION, ...
Authors:Zhao, K., Harshaw, R., Chai, X., Marmorstein, R.
Deposit date:2004-04-05
Release date:2004-06-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1SZD
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STRUCTURAL BASIS FOR NICOTINAMIDE CLEAVAGE AND ADP-RIBOSE TRANSFER BY NAD+-DEPENDENT SIR2 HISTONE/PROTEIN DEACETYLASES
Descriptor:NAD-dependent deacetylase HST2, Histone H4 peptide, CHLORIDE ION, ...
Authors:Zhao, K., Harshaw, R., Chai, X., Marmorstein, R.
Deposit date:2004-04-05
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1JIA
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STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Zhao, K., Lin, Z.
Deposit date:1997-06-09
Release date:1998-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structure of a basic phospholipase A2 from Agkistrodon halys Pallas at 2.13 A resolution.
Acta Crystallogr.,Sect.D, 54, 1998
1Q17
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STRUCTURE OF THE YEAST HST2 PROTEIN DEACETYLASE IN TERNARY COMPLEX WITH 2'-O-ACETYL ADP RIBOSE AND HISTONE PEPTIDE
Descriptor:HST2 protein, ZINC ION, CHLORIDE ION, ...
Authors:Zhao, K., Chai, X., Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-11-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2'-O-Acetyl ADP Ribose and Histone Peptide.
Structure, 11, 2003
1Q1A
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STRUCTURE OF THE YEAST HST2 PROTEIN DEACETYLASE IN TERNARY COMPLEX WITH 2'-O-ACETYL ADP RIBOSE AND HISTONE PEPTIDE
Descriptor:HST2 protein, Histone H4, ZINC ION, ...
Authors:Zhao, K., Chai, X., Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-Acetyl ADP ribose and histone peptide.
Structure, 11, 2003
1HU8
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CRYSTAL STRUCTURE OF THE MOUSE P53 CORE DNA-BINDING DOMAIN AT 2.7A RESOLUTION
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Zhao, K., Chai, X., Johnston, K., Clements, A., Marmorstein, R.
Deposit date:2001-01-04
Release date:2001-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution.
J.Biol.Chem., 276, 2001
1NFH
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STRUCTURE OF A SIR2 SUBSTRATE, ALBA, REVEALS A MECHANISM FOR DEACTYLATION-INDUCED ENHANCEMENT OF DNA-BINDING
Descriptor:conserved hypothetical protein AF1956
Authors:Zhao, K., Chai, X., Marmorstein, R.
Deposit date:2002-12-15
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of a Sir2 substrate, Alba, reveals a mechanism for deacetylation-induced enhancement of DNA-binding
J.Biol.Chem., 278, 2003
1NFJ
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STRUCTURE OF A SIR2 SUBSTRATE, ALBA, REVEALS A MECHANISM FOR DEACTYLATION-INDUCED ENHANCEMENT OF DNA-BINDING
Descriptor:conserved hypothetical protein AF1956
Authors:Zhao, K., Chai, X., Marmorstein, R.
Deposit date:2002-12-15
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a Sir2 substrate, alba, reveals a mechanism for deacetylation-induced enhancement of DNA-binding
J.Biol.Chem., 278, 2003
1Q14
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STRUCTURE AND AUTOREGULATION OF THE YEAST HST2 HOMOLOG OF SIR2
Descriptor:HST2 protein, ZINC ION, CHLORIDE ION
Authors:Zhao, K., Chai, X., Clements, A., Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and autoregulation of the Yeast Hst2 homolog of Sir2
Nat.Struct.Biol., 10, 2003
1S5P
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STRUCTURE AND SUBSTRATE BINDING PROPERTIES OF COBB, A SIR2 HOMOLOG PROTEIN DEACETYLASE FROM ESCHERICIA COLI.
Descriptor:NAD-dependent deacetylase, HISTONE H4 (RESIDUES 12-19), ZINC ION
Authors:Zhao, K., Chai, X., Marmorstein, R.
Deposit date:2004-01-21
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structure and Substrate Binding Properties of cobB, a Sir2 Homolog Protein Deacetylase from Eschericia coli.
J.Mol.Biol., 337, 2004
5H19
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED162
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5GSA
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EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-08-15
Release date:2017-02-01
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
5H13
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED396
Descriptor:Polycomb protein EED, GLYCEROL, PRASEODYMIUM ION, ...
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H14
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EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR EED666
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, GLYCEROL, ...
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H15
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED709
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H17
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED210
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, (3R,4aS,10aS)-6-methoxy-3-[(3-methoxyphenyl)methyl]-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H24
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR COMPOUND 8
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-14
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5H25
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR COMPOUND 11
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-14
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
3TG4
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STRUCTURE OF SMYD2 IN COMPLEX WITH SAM
Descriptor:N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION, ...
Authors:Zhao, K., Wang, L.
Deposit date:2011-08-17
Release date:2011-08-31
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation
J.Biol.Chem., 2011
3TG5
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STRUCTURE OF SMYD2 IN COMPLEX WITH P53 AND SAH
Descriptor:N-lysine methyltransferase SMYD2, Cellular tumor antigen p53, GLYCEROL, ...
Authors:Zhao, K., Wang, L.
Deposit date:2011-08-17
Release date:2011-08-31
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation
J.Biol.Chem., 2011
4QQN
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PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH COMPOUND MTV044246
Descriptor:PRMT3 protein, 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, GLYCEROL, ...
Authors:Dong, A., Dobrovetsky, E., Tempel, W., He, H., Zhao, K., Smil, D., Landon, M., Luo, X., Chen, Z., Dai, M., Yu, Z., Lin, Y., Zhang, H., Zhao, K., Schapira, M., Brown, P.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-09-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).
J. Med. Chem., 61, 2018
1ZX2
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CRYSTAL STRUCTURE OF YEAST UBP3-ASSOCIATED PROTEIN BRE5
Descriptor:UBP3-associated protein BRE5
Authors:Li, K., Zhao, K., Ossareh-Nazari, B., Da, G., Dargemont, C., Marmorstein, R.
Deposit date:2005-06-06
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor
J.Biol.Chem., 280, 2005
4RYL
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HUMAN PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH 1-ISOQUINOLIN-6-YL-3-[2-OXO-2-(PYRROLIDIN-1-YL)ETHYL]UREA
Descriptor:PRMT3 protein, 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, UNKNOWN ATOM OR ION
Authors:Dong, A., Dobrovetsky, E., Kaniskan, H.U., Szewczyk, M., Yu, Z., Eram, M.S., Yang, X., Schmidt, K., Luo, X., Dai, M., He, F., Zang, I., Lin, Y., Kennedy, S., Li, F., Tempel, W., Smil, D., Min, S.J., Landon, M., Lin-Jones, J., Huang, X.P., Roth, B.L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Brown, P.J., Zhao, K., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)
Deposit date:2014-12-15
Release date:2015-02-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
Angew.Chem.Int.Ed.Engl., 54, 2015
2B9D
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CRYSTAL STRUCTURE OF HPV E7 CR3 DOMAIN
Descriptor:E7 protein, ZINC ION
Authors:Liu, X., Clements, A., Zhao, K., Marmorstein, R.
Deposit date:2005-10-11
Release date:2005-10-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.
J.Biol.Chem., 281, 2006
2FQ3
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STRUCTURE AND FUNCTION OF THE SWIRM DOMAIN, A CONSERVED PROTEIN MODULE FOUND IN CHROMATIN REGULATORY COMPLEXES
Descriptor:Transcription regulatory protein SWI3
Authors:Da, G., Lenkart, J., Zhao, K., Shiekhattar, R., Cairns, B.R., Marmorstein, R.
Deposit date:2006-01-17
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes
Proc.Natl.Acad.Sci.Usa, 103, 2006
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