8JH6

Crystal structure of apixaban-bound racemic ABLE

Summary for 8JH6

Entry DOI	10.2210/pdb8jh6/pdb
Descriptor	D-ABLE, L-ABLE, 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ... (4 entities in total)
Functional Keywords	small molecule-binding protein, racemic protein, de novo protein
Biological source	synthetic construct More
Total number of polymer chains	2
Total formula weight	28543.90
Authors	Zhao, K.,Li, T. (deposition date: 2023-05-22, release date: 2024-05-29, Last modification date: 2025-06-04)
Primary citation	Zhao, K.,Li, T. Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants Nat Biomed Eng, 2025 Cited by DOI: 10.1038/s41551-025-01404-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation