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5LZS
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STRUCTURE OF THE MAMMALIAN RIBOSOMAL ELONGATION COMPLEX WITH AMINOACYL-TRNA, EEF1A, AND DIDEMNIN B
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZT
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STRUCTURE OF THE MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ERF1 AND ERF3.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZU
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STRUCTURE OF THE MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ACCOMMODATED ERF1
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
4YHF
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BRUTON'S TYROSINE KINASE IN COMPLEX WITH A T-BUTYL CYANOACRYLAMIDE INHIBITOR
Descriptor:Tyrosine-protein kinase BTK, (2S)-2-({(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile, SODIUM ION, ...
Authors:Paavilainen, V.O., McFarland, J.M., Taunton, J.
Deposit date:2015-02-27
Release date:2015-05-13
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Prolonged and tunable residence time using reversible covalent kinase inhibitors.
Nat.Chem.Biol., 11, 2015
5K9I
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CRYSTAL STRUCTURE OF C-SRC IN COMPLEX WITH A COVALENT LYSINE PROBE
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride
Authors:Wan, X., Ouyang, S., Zhao, Q., Taunton, J.
Deposit date:2016-05-31
Release date:2017-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.
J. Am. Chem. Soc., 139, 2017
5LZV
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STRUCTURE OF THE MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ACCOMMODATED ERF1(AAQ) AND ABCE1.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZW
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A TRUNCATED MRNA.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZX
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A UGA STOP CODON.
Descriptor:uL2, Ul3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZY
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A POLYADENYLATED MRNA.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.99 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZZ
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L (COMBINED)
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
4D9T
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RSK2 C-TERMINAL KINASE DOMAIN WITH INHIBITOR (E)-METHYL 3-(4-AMINO-7-(3-HYDROXYPROPYL)-5-P-TOLYL-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-2-CYANOACRYLATE
Descriptor:Ribosomal protein S6 kinase alpha-3, methyl (2S)-3-{4-amino-7-[(1E)-3-hydroxyprop-1-en-1-yl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl}-2-cyanopropanoate, SODIUM ION
Authors:Serafimova, I.M., Pufall, M.A., Krishnan, S., Duda, K., Cohen, M.S., Maglathlin, R.L., McFarland, J.M., Miller, R.M., Frodin, M., Taunton, J.
Deposit date:2012-01-12
Release date:2012-04-25
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
Nat.Chem.Biol., 8, 2012
4D9U
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RSK2 C-TERMINAL KINASE DOMAIN, (E)-TERT-BUTYL 3-(4-AMINO-7-(3-HYDROXYPROPYL)-5-P-TOLYL-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-2-CYANOACRYLATE
Descriptor:Ribosomal protein S6 kinase alpha-3, tert-butyl (2S)-3-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyanopropanoate, SODIUM ION
Authors:Serafimova, I.M., Pufall, M.A., Krishnan, S., Duda, K., Cohen, M.S., Maglathlin, R.L., McFarland, J.M., Miller, R.M., Frodin, M., Taunton, J.
Deposit date:2012-01-12
Release date:2012-04-11
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
Nat.Chem.Biol., 8, 2012
4JG6
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RSK2 CTD BOUND TO 2-CYANO-3-(1H-INDAZOL-5-YL)ACRYLAMIDE
Descriptor:Ribosomal protein S6 kinase alpha-3, (2S)-2-cyano-3-(1H-indazol-5-yl)propanamide, SODIUM ION
Authors:Miller, R.M., Paavilainen, V.O., Krishnan, S., Serafimova, I.M., Taunton, J.
Deposit date:2013-02-28
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
4JG7
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STRUCTURE OF RSK2 CTD BOUND TO 3-(3-(1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)PHENYL)-2-CYANOACRYLAMIDE
Descriptor:Ribosomal protein S6 kinase alpha-3, (2R)-2-cyano-3-[3-(1H-pyrrolo[2,3-b]pyridin-3-ylcarbonyl)phenyl]propanamide, SODIUM ION
Authors:Miller, R.M., Paavilainen, V.O., Krishnan, S., Serafimova, I.M., Taunton, J.
Deposit date:2013-02-28
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.0002 Å)
Cite:Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
4JG8
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STRUCTURE OF RSK2 T493M CTD MUTANT BOUND TO 2-CYANO-N-(1-HYDROXY-2-METHYLPROPAN-2-YL)-3-(3-(3,4,5-TRIMETHOXYPHENYL)-1H-INDAZOL-5-YL)ACRYLAMIDE
Descriptor:Ribosomal protein S6 kinase alpha-3, (2S)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]propanamide
Authors:Miller, R.M., Paavilainen, V.O., Krishnan, S., Serafimova, I.M., Taunton, J.
Deposit date:2013-02-28
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.1002 Å)
Cite:Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
4M8T
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RSK2 T493M C-TERMINAL KINASE DOMAIN IN COMPLEX WITH 3-(3-(1H-PYRAZOL-4-YL)PHENYL)-2-CYANOACRYLAMIDE
Descriptor:Ribosomal protein S6 kinase alpha-3, (2E)-2-cyano-3-[3-(1H-pyrazol-4-yl)phenyl]prop-2-enamide, SODIUM ION
Authors:Miller, R.M., Taunton, J.
Deposit date:2013-08-13
Release date:2014-10-22
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Covalent docking of large libraries for the discovery of chemical probes.
Nat.Chem.Biol., 10, 2014
4MAO
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RSK2 T493M C-TERMINAL KINASE DOMAIN IN COMPLEX WITH RMM58
Descriptor:Ribosomal protein S6 kinase alpha-3, (2Z)-2-(1H-1,2,4-triazol-1-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enenitrile, SODIUM ION
Authors:Miller, R.M., Taunton, J.
Deposit date:2013-08-16
Release date:2014-10-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
J.Am.Chem.Soc., 136, 2014
6U06
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DISCOVERY OF LYSINE-TARGETED EIF4E INHIBITORS THROUGH COVALENT DOCKING
Descriptor:Eukaryotic translation initiation factor 4E, 3-{[(4-cyanophenyl)methyl](1-oxo-1,2-dihydroisoquinolin-7-yl)sulfamoyl}benzene-1-sulfonyl fluoride
Authors:Wan, X.B., Shoichet, B.K., Taunton, J.
Deposit date:2019-08-13
Release date:2019-10-16
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Discovery of Novel Covalent eIF4E Lysine Inhibitors through Covalent Docking
To Be Published
6U09
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DISCOVERY OF LYSINE-TARGETED EIF4E INHIBITORS THROUGH COVALENT DOCKING
Descriptor:Eukaryotic translation initiation factor 4E, 3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl)methyl]sulfamoyl}benzene-1-sulfonyl fluoride
Authors:Wan, X.B., Shoichet, B.K., Taunton, J.
Deposit date:2019-08-13
Release date:2019-10-23
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of Novel Covalent eIF4E Lysine Inhibitors through Covalent Docking
to be published
6U98
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HSP90A NTD K58R BOUND REVERSIBLY TO SULFONYL FLUORIDE 6
Descriptor:Heat shock protein HSP 90-alpha, 3-{[(3R)-3-({6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}methyl)piperidin-1-yl]methyl}benzene-1-sulfonyl fluoride, POTASSIUM ION, ...
Authors:Cuesta, A., Wan, X., Taunton, J.
Deposit date:2019-09-06
Release date:2020-02-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.
J.Am.Chem.Soc., 2020
6U99
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HSP90A NTD COVALENTLY BOUND TO SULFONYL FLUORIDE PROBE 1 AT K58
Descriptor:Heat shock protein HSP 90-alpha, 3-{[(3-{6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}propyl)amino]methyl}benzene-1-sulfinic acid
Authors:Cuesta, A., Wan, X., Taunton, J.
Deposit date:2019-09-06
Release date:2020-02-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.
J.Am.Chem.Soc., 2020
6U9A
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HSP90A NTD K58R BOUND REVERSIBLY TO SULFONYL FLUORIDE 5
Descriptor:Heat shock protein HSP 90-alpha, 3-{[(3S)-3-({6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}methyl)piperidin-1-yl]methyl}benzene-1-sulfonyl fluoride
Authors:Cuesta, A., Wan, X., Taunton, J.
Deposit date:2019-09-07
Release date:2020-02-19
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.
J.Am.Chem.Soc., 2020
6U9B
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HSP90A NTD COVALENTLY BOUND TO SULFONYL FLUORIDE 5 AT K58
Descriptor:Heat shock protein HSP 90-alpha, 3-{[(3S)-3-({6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}methyl)piperidin-1-yl]methyl}benzene-1-sulfonyl fluoride
Authors:Cuesta, A., Wan, X., Taunton, J.
Deposit date:2019-09-07
Release date:2020-02-19
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.
J.Am.Chem.Soc., 2020
5U8L
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CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH A SULFONYL FLUORIDE PROBE XO44
Descriptor:Epidermal growth factor receptor, 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride, SULFATE ION, ...
Authors:Gajiwala, K.S., Ferre, R.
Deposit date:2016-12-14
Release date:2017-01-25
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.
J. Am. Chem. Soc., 139, 2017
3QBV
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STRUCTURE OF DESIGNED ORTHOGONAL INTERACTION BETWEEN CDC42 AND NUCLEOTIDE EXCHANGE DOMAINS OF INTERSECTIN
Descriptor:Cell division control protein 42 homolog, Intersectin-1, GUANOSINE-5'-DIPHOSPHATE
Authors:Kapp, G.T., Remenyi, A., Lim, W.A., Kortemme, T.
Deposit date:2011-01-14
Release date:2012-02-08
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
Proc.Natl.Acad.Sci.USA, 109, 2012
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