Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5K9I

Crystal structure of c-SRC in complex with a covalent lysine probe

Summary for 5K9I
Entry DOI10.2210/pdb5k9i/pdb
DescriptorProto-oncogene tyrosine-protein kinase Src, 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride (3 entities in total)
Functional Keywordscovalent lysine probe, transferase
Biological sourceGallus gallus (Chicken)
Cellular locationCell membrane : P00523
Total number of polymer chains2
Total formula weight66530.48
Authors
Wan, X.,Ouyang, S.,Zhao, Q.,Taunton, J. (deposition date: 2016-05-31, release date: 2017-02-01)
Primary citationZhao, Q.,Ouyang, X.,Wan, X.,Gajiwala, K.S.,Kath, J.C.,Jones, L.H.,Burlingame, A.L.,Taunton, J.
Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.
J. Am. Chem. Soc., 139:680-685, 2017
Cited by
PubMed: 28051857
DOI: 10.1021/jacs.6b08536
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon