5K9I
Crystal structure of c-SRC in complex with a covalent lysine probe
Summary for 5K9I
Entry DOI | 10.2210/pdb5k9i/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride (3 entities in total) |
Functional Keywords | covalent lysine probe, transferase |
Biological source | Gallus gallus (Chicken) |
Cellular location | Cell membrane : P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66530.48 |
Authors | |
Primary citation | Zhao, Q.,Ouyang, X.,Wan, X.,Gajiwala, K.S.,Kath, J.C.,Jones, L.H.,Burlingame, A.L.,Taunton, J. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. J. Am. Chem. Soc., 139:680-685, 2017 Cited by PubMed: 28051857DOI: 10.1021/jacs.6b08536 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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