Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6U9B

Hsp90a NTD covalently bound to sulfonyl fluoride 5 at K58

Summary for 6U9B
Entry DOI10.2210/pdb6u9b/pdb
Related6U98 6U99 6U9A
DescriptorHeat shock protein HSP 90-alpha, 3-{[(3S)-3-({6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}methyl)piperidin-1-yl]methyl}benzene-1-sulfonyl fluoride (3 entities in total)
Functional Keywordsinhibitor, lysine-targeted inhibitor, chaperone, chaperone-inhibitor complex, chaperone/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight29362.52
Authors
Cuesta, A.,Wan, X.,Taunton, J. (deposition date: 2019-09-07, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citationCuesta, A.,Wan, X.,Burlingame, A.L.,Taunton, J.
Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.
J.Am.Chem.Soc., 142:3392-3400, 2020
Cited by
PubMed: 32009391
DOI: 10.1021/jacs.9b09684
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon