6U99
Hsp90a NTD covalently bound to sulfonyl fluoride probe 1 at K58
Summary for 6U99
Entry DOI | 10.2210/pdb6u99/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 3-{[(3-{6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}propyl)amino]methyl}benzene-1-sulfinic acid (3 entities in total) |
Functional Keywords | inhibitor, lysine-targeted inhibitor, chaperone, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29304.46 |
Authors | Cuesta, A.,Wan, X.,Taunton, J. (deposition date: 2019-09-06, release date: 2020-02-19, Last modification date: 2023-10-11) |
Primary citation | Cuesta, A.,Wan, X.,Burlingame, A.L.,Taunton, J. Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90. J.Am.Chem.Soc., 142:3392-3400, 2020 Cited by PubMed: 32009391DOI: 10.1021/jacs.9b09684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report