8F93
WDR5 covalently modified at Y228 by (R)-2-SF
Summary for 8F93
Entry DOI | 10.2210/pdb8f93/pdb |
Descriptor | WD repeat-containing protein 5, 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, GLYCEROL, ... (6 entities in total) |
Functional Keywords | covalent inhibition, y228, sulfonyl fluoride, ppi, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 71079.19 |
Authors | Taunton, J.,Craven, G.B.,Chen, Y. (deposition date: 2022-11-23, release date: 2023-05-31, Last modification date: 2023-11-15) |
Primary citation | Chen, Y.,Craven, G.B.,Kamber, R.A.,Cuesta, A.,Zhersh, S.,Moroz, Y.S.,Bassik, M.C.,Taunton, J. Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15:1616-1625, 2023 Cited by PubMed: 37460812DOI: 10.1038/s41557-023-01281-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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