Author results

4F59
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TRIPLE MUTANT SRC SH2 DOMAIN
分子名称:Proto-oncogene tyrosine-protein kinase Src
著者Kaneko, T., Huang, H., Cao, X., Li, C., Voss, C., Sidhu, S.S., Li, S.S.
登録日2012-05-12
公開日2012-10-03
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4F5A
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TRIPLE MUTANT SRC SH2 DOMAIN BOUND TO PHOSPHATE ION
分子名称:Proto-oncogene tyrosine-protein kinase Src, PHOSPHATE ION
著者Kaneko, T., Huang, H., Cao, X., Li, C., Voss, C., Sidhu, S.S., Li, S.S.
登録日2012-05-12
公開日2012-10-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4F5B
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TRIPLE MUTANT SRC SH2 DOMAIN BOUND TO PHOSPHOTYROSINE
分子名称:Proto-oncogene tyrosine-protein kinase Src, O-PHOSPHOTYROSINE
著者Kaneko, T., Huang, H., Cao, X., Li, C., Voss, C., Sidhu, S.S., Li, S.S.
登録日2012-05-12
公開日2012-10-03
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
1TZH
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CRYSTAL STRUCTURE OF THE FAB YADS1 COMPLEXED WITH H-VEGF
分子名称:Vascular endothelial growth factor A, Fab YADS1 Light Chain, Fab YADS1 Heavy Chain
著者Fellouse, F.A., Wiesmann, C., Sidhu, S.S.
登録日2004-07-09
公開日2004-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
1TZI
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CRYSTAL STRUCTURE OF THE FAB YADS2 COMPLEXED WITH H-VEGF
分子名称:Fab YADS2 Light Chain, Fab YADS2 Heavy Chain, Vascular endothelial growth factor A
著者Fellouse, F.A., Wiesmann, C., Sidhu, S.S.
登録日2004-07-10
公開日2004-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
2H2B
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CRYSTAL STRUCTURE OF ZO-1 PDZ1 BOUND TO A PHAGE-DERIVED LIGAND (WRRTTYL)
分子名称:Tight junction protein ZO-1, ACETIC ACID
著者Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
登録日2006-05-18
公開日2006-06-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H2C
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CRYSTAL STRUCTURE OF ZO-1 PDZ1 BOUND TO A PHAGE-DERIVED LIGAND (WRRTTWV)
分子名称:Tight junction protein ZO-1
著者Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
登録日2006-05-18
公開日2006-06-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H3L
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CRYSTAL STRUCTURE OF ERBIN PDZ
分子名称:LAP2 protein
著者Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
登録日2006-05-22
公開日2006-06-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H3M
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CRYSTAL STRUCTURE OF ZO-1 PDZ1
分子名称:Tight junction protein ZO-1, SULFATE ION
著者Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
登録日2006-05-22
公開日2006-06-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
1L7I
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CRYSTAL STRUCTURE OF THE ANTI-ERBB2 FAB2C4
分子名称:chimera of Fab2C4: "humanized" murine monoclonal antibody, SULFATE ION
著者Vajdos, F.F., Adams, C.W., Breece, T.N., Presta, L.G., de Vos, A.M., Sidhu, S.S.
登録日2002-03-15
公開日2002-07-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis.
J.Mol.Biol., 320, 2002
1LB7
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IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1
分子名称:IGF-1 ANTAGONIST F1-1
著者Deshayes, K., Schaffer, M.L., Skelton, N.J., Nakamura, G.R., Kadkhodayan, S., Sidhu, S.S.
登録日2002-04-02
公開日2002-06-19
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function.
Chem.Biol., 9, 2002
1N7T
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ERBIN PDZ DOMAIN BOUND TO A PHAGE-DERIVED PEPTIDE
分子名称:99-mer peptide of densin-180-like protein, phage-derived peptide
著者Skelton, N.J., Koehler, M.F.T., Zobel, K., Wong, W.L., Yeh, S., Pisabarro, M.T., Yin, J.P., Lasky, L.A., Sidhu, S.S.
登録日2002-11-16
公開日2003-01-28
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain.
J.Biol.Chem., 278, 2003
1SHM
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CONVERGENT SOLUTIONS TO VHH DOMAIN STABILIZATION FROM NATURAL AND IN VITRO EVOLUTION
分子名称:ANTIBODY RIG
著者Bond, C.J., Wiesmann, C., Marsters, J.C., Sidhu, S.S.
登録日2004-02-26
公開日2005-03-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A structure-based database of antibody variable domain diversity.
J.Mol.Biol., 348, 2005
1ZA3
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THE CRYSTAL STRUCTURE OF THE YSD1 FAB BOUND TO DR5
分子名称:Fab-YSd1 light chain, Fab-YSd1 heavy chain, Tumor necrosis factor receptor superfamily member 10B
著者Fellouse, F.A., Li, B., Compaan, D.M., Peden, A.A., Hymowitz, S.G., Sidhu, S.S.
登録日2005-04-05
公開日2005-06-14
最終更新日2014-02-05
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Molecular recognition by a binary code.
J.Mol.Biol., 348, 2005
2JOA
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HTRA1 BOUND TO AN OPTIMIZED PEPTIDE: NMR ASSIGNMENT OF PDZ DOMAIN AND LIGAND RESONANCES
分子名称:Serine protease HTRA1, Peptide H1-C1
著者Runyon, S.T., Zhang, Y., Appleton, B.A., Sazinksy, S.L., Wu, P., Pan, B., Wiesmann, C., Skelton, N.J., Sidhu, S.S.
登録日2007-03-01
公開日2007-11-20
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3
Protein Sci., 16, 2007
2R8S
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HIGH RESOLUTION STRUCTURE OF A SPECIFIC SYNTHETIC FAB BOUND TO P4-P6 RNA RIBOZYME DOMAIN
分子名称:P4-P6 RNA RIBOZYME DOMAIN, Fab light chain, Fab heavy chain, ...
著者Ye, J.D., Tereshko, V., Sidhu, S.S., Koide, S., Kossiakoff, A.A., Piccirilli, J.A.
登録日2007-09-11
公開日2007-12-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Synthetic antibodies for specific recognition and crystallization of structured RNA
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EFD
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THE CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF KCSA
分子名称:FabL, FabH, KcsA
著者Uysal, S., Vasquez, V., Tereshko, V., Esaki, K., Fellouse, F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A.
登録日2008-09-08
公開日2009-04-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of full-length KcsA in its closed conformation.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EFF
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THE CRYSTAL STRUCTURE OF FULL-LENGTH KCSA IN ITS CLOSED CONFORMATION
分子名称:FAB, Voltage-gated potassium channel
著者Uysal, S., Vasquez, V., Tereshko, T., Esaki, K., Fellouse, F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A.
登録日2008-09-08
公開日2009-04-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal structure of full-length KcsA in its closed conformation.
Proc.Natl.Acad.Sci.USA, 106, 2009
3PNW
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CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN TDRD3 IN COMPLEX WITH AN ANTI-TDRD3 FAB
分子名称:FAB light chain, FAB heavy chain, Tudor domain-containing protein 3, ...
著者Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC)
登録日2010-11-19
公開日2010-12-01
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies.
J.Mol.Biol., 425, 2013
5JG6
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APC11-UBV SHOWS ROLE OF NONCOVALENT RING-UBIQUITIN INTERACTIONS IN PROCESSIVE MULTIUBIQUITINATION AND UBIQUITIN CHAIN ELONGATION BY APC/C
分子名称:Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION
著者Brown, N.G., Zhang, W., Yu, S., Miller, D.J., Sidhu, S.S., Schulman, B.A.
登録日2016-04-19
公開日2016-06-15
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.0013 Å)
主引用文献Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5VEI
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN OF HUMAN SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 2
分子名称:Sorbin and SH3 domain-containing protein 2, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Huang, H., Gu, J., Liu, K., Sidhu, S.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-04-04
公開日2017-08-02
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2
To be Published
6CPM
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STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A THIRD-GENERATION INHIBITORY UBV
分子名称:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1d, CALCIUM ION, ...
著者Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
登録日2018-03-13
公開日2019-01-23
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.011 Å)
主引用文献Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6CRN
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STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A HIGH-AFFINITY FIRST-GENERATION UBV
分子名称:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION
著者Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
登録日2018-03-19
公開日2019-01-23
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6DJ9
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STRUCTURE OF THE USP15 DUSP DOMAIN IN COMPLEX WITH A HIGH-AFFINITY UBIQUITIN VARIANT (UBV)
分子名称:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin Variant UbV 15.D
著者Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
登録日2018-05-24
公開日2019-01-23
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6EDF
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FRAGMENT OF A TYROSINE-PROTEIN KINASE
分子名称:FYN, GLYCEROL, UNKNOWN ATOM OR ION
著者Tempel, W., Huang, H., Sochirca, I., Liu, K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Sidhu, S.S., Min, J., Structural Genomics Consortium (SGC)
登録日2018-08-09
公開日2018-08-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Fragment of a tyrosine-protein kinase
To be Published