7T1U
Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide
Summary for 7T1U
Entry DOI | 10.2210/pdb7t1u/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION, ... (4 entities in total) |
Functional Keywords | src homology 2 (sh2), rationally engineered, phosphotyrosine, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 27553.80 |
Authors | Martyn, G.D.,Singer, A.U.,Manczyk, N.,Veggiani, G.,Kurinov, I.,Sicheri, F.,Sidhu, S.S. (deposition date: 2021-12-02, release date: 2022-08-24, Last modification date: 2023-11-15) |
Primary citation | Martyn, G.D.,Veggiani, G.,Kusebauch, U.,Morrone, S.R.,Yates, B.P.,Singer, A.U.,Tong, J.,Manczyk, N.,Gish, G.,Sun, Z.,Kurinov, I.,Sicheri, F.,Moran, M.F.,Moritz, R.L.,Sidhu, S.S. Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17:1472-1484, 2022 Cited by PubMed: 35613471DOI: 10.1021/acschembio.2c00051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report