8T7F

Structure of the S1 variant of Fab F1

Summary for 8T7F

• Entry DOI: 10.2210/pdb8t7f/pdb
• Related: 8T7G 8T7I
• Descriptor: S1 variant of Fab F1 heavy chain, S1 variant of Fab F1 light chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: enhanced crystallization, epha2 binding, engineered protein, fab, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 293536.06

Authors

Singer, A.U.,Bruce, H.A.,Enderle, L.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-06-20, release date: 2023-11-22, Last modification date: 2024-01-10)

• Primary citation: Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S.; Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.; Protein Sci., 33:e4824-e4824, 2024; PubMed: 37945533; DOI: 10.1002/pro.4824

Experimental method

X-RAY DIFFRACTION (3.5 Å)