8C3N
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8C3J
| Stapled peptide SP2 in complex with humanised RadA mutant HumRadA22 | Descriptor: | 2-[(4,6-diethyl-1,3,5-triazin-2-yl)-methyl-amino]ethanoic acid, Breast cancer type 2 susceptibility protein, DNA repair and recombination protein RadA | Authors: | Pantelejevs, T, Hyvonen, M. | Deposit date: | 2022-12-26 | Release date: | 2023-11-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chem Sci, 14, 2023
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8BR9
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7QV8
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7NUF
| Vaccinia virus protein 018 in complex with STAT1 | Descriptor: | ACETYL GROUP, SULFATE ION, Signal transducer and activator of transcription 1-alpha/beta, ... | Authors: | Pantelejevs, T, Talbot-Cooper, C, Smith, G.L, Hyvonen, M. | Deposit date: | 2021-03-12 | Release date: | 2021-07-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.0004015 Å) | Cite: | Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. Cell Host Microbe, 30, 2022
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6Y4Q
| Structure of a stapled peptide bound to MDM2 | Descriptor: | ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER, E3 ubiquitin-protein ligase Mdm2, ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide | Authors: | Pantelejevs, T, Bakanovych, I. | Deposit date: | 2020-02-22 | Release date: | 2020-05-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Org.Biomol.Chem., 18, 2020
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6TUU
| Leishmania infantum Rad51 surrogate LiRadA10 in complex with 5,6,7,8-tetrahydro-2-naphthoic acid | Descriptor: | 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid, CHLORIDE ION, DNA repair and recombination protein RadA, ... | Authors: | Pantelejevs, T, Hyvonen, M. | Deposit date: | 2020-01-08 | Release date: | 2021-01-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Development of dedicated crystallographic systems for structure-guided drug discovery To Be Published
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6HQU
| Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility, DNA repair and recombination protein RadA, ... | Authors: | Pantelejevs, T, Lindenburg, L, Hyvonen, M, Hollfelder, F. | Deposit date: | 2018-09-25 | Release date: | 2019-10-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. Proc.Natl.Acad.Sci.USA, 118, 2021
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3Q1R
| Crystal structure of a bacterial RNase P holoenzyme in complex with TRNA and in the presence of 5' leader | Descriptor: | MAGNESIUM ION, RNase P RNA, Ribonuclease P protein component, ... | Authors: | Reiter, N.J, Ostermanm, A, Torres-Larios, A, Swinger, K.K, Pan, T, Mondragon, A. | Deposit date: | 2010-12-17 | Release date: | 2011-03-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (4.21 Å) | Cite: | Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA. Nature, 468, 2010
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3Q1Q
| Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, RNase P RNA, ... | Authors: | Reiter, N.J, Osterman, A, Torres-Larios, A, Swinger, K.K, Pan, T, Mondragon, A. | Deposit date: | 2010-12-17 | Release date: | 2011-03-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA. Nature, 468, 2010
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2A2E
| Crystal structure of the RNA subunit of Ribonuclease P. Bacterial A-type. | Descriptor: | OSMIUM ION, RNA subunit of RNase P | Authors: | Torres-Larios, A, Swinger, K.K, Krasilnikov, A.S, Pan, T, Mondragon, A. | Deposit date: | 2005-06-22 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | Crystal structure of the RNA component of bacterial ribonuclease P. Nature, 437, 2005
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1U9S
| Crystal structure of the specificity domain of Ribonuclease P of the A-type | Descriptor: | BARIUM ION, RIBONUCLEASE P | Authors: | Krasilnikov, A.S, Xiao, Y, Pan, T, Mondragon, A. | Deposit date: | 2004-08-10 | Release date: | 2004-10-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Basis for structural diversity in homologous RNAs. Science, 306, 2004
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1NBS
| Crystal structure of the specificity domain of Ribonuclease P RNA | Descriptor: | LEAD (II) ION, MAGNESIUM ION, RIBONUCLEASE P RNA | Authors: | Krasilnikov, A.S, Yang, X, Pan, T, Mondragon, A. | Deposit date: | 2002-12-03 | Release date: | 2003-02-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Crystal structure of the specificity domain of Ribonuclease P Nature, 421, 2003
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7ZWD
| Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | Deposit date: | 2022-05-19 | Release date: | 2022-11-30 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
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7ZX7
| Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (CC) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | Deposit date: | 2022-05-20 | Release date: | 2022-11-30 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
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7ZXE
| Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) | Descriptor: | Non-template strand, TATA-box-binding protein, Template strand, ... | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | Deposit date: | 2022-05-20 | Release date: | 2022-11-30 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
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7ZX8
| Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | Deposit date: | 2022-05-20 | Release date: | 2022-12-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
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7ZWC
| Structure of SNAPc:TBP-TFIIA-TFIIB sub-complex bound to U5 snRNA promoter | Descriptor: | Non-template strand, TATA-box-binding protein, Template strand, ... | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | Deposit date: | 2022-05-19 | Release date: | 2022-11-30 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
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5V47
| Crystal structure of the SR1 domain of lizard sacsin | Descriptor: | Lizard sacsin, SULFATE ION | Authors: | Pan, T, Menade, M, Kozlov, G, Gehring, K. | Deposit date: | 2017-03-08 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations. J. Biol. Chem., 293, 2018
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6O76
| Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain | Descriptor: | CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic | Authors: | Kuhle, B, Yang, X.L. | Deposit date: | 2019-03-07 | Release date: | 2019-09-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.787 Å) | Cite: | CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells. Proc.Natl.Acad.Sci.USA, 116, 2019
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1LDZ
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5KNN
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2LDZ
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6JBH
| Cryo-EM structure and transport mechanism of a wall teichoic acid ABC transporter | Descriptor: | TarG, TarH | Authors: | Chen, L, Hou, W.T, Fan, T, Li, Y.H, Liu, B.H, Jiang, Y.L, Sun, L.F, Chen, Y, Zhou, C.Z. | Deposit date: | 2019-01-25 | Release date: | 2020-03-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter. Mbio, 11, 2020
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5W6M
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