Author results

1T3L
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STRUCTURAL ANALYSIS OF THE VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT FUNCTIONAL CORE IN COMPLEX WITH ALPHA1 INTERACTION DOMAIN
Descriptor:Dihydropyridine-sensitive L-type, calcium channel beta-2 subunit, Voltage-dependent L-type calcium channel alpha-1S subunit
Authors:Opatowsky, Y., Chen, C.-C., Campbell, K.P., Hirsch, J.A.
Deposit date:2004-04-27
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of Voltage-Dependent Calcium Channel Beta Subunit Functional Core and Its Complex with the Alpha1 Interaction Domain
NEURON, 42, 2004
1T3S
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STRUCTURAL ANALYSIS OF THE VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT FUNCTIONAL CORE
Descriptor:Dihydropyridine-sensitive L-type, calcium channel beta-2 subunit, MERCURY (II) ION
Authors:Opatowsky, Y., Chen, C.-C., Campbell, K.P., Hirsch, J.A.
Deposit date:2004-04-27
Release date:2004-05-25
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain.
Neuron, 42, 2004
2HT6
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CRYSTAL STRUCTURE OF HUMAN GEM G-DOMAIN BOUND TO GDP
Descriptor:GTP-binding protein GEM, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Opatowsky, Y., Hirsch, J.A.
Deposit date:2006-07-25
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-function studies of the G-domain from human gem, a novel small G-protein.
Febs Lett., 580, 2006
4PQJ
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CRYSTAL STRUCTURE OF A PHOSPHATE BINDING PROTEIN
Descriptor:Phosphate binding protein, PHOSPHATE ION
Authors:Opatowsky, Y., Neznansky, A.
Deposit date:2014-03-03
Release date:2015-03-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of a phosphate binding protein
TO BE PUBLISHED
4RTT
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CYRSTAL STRUCTURE OF SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2 FRAGMENT
Descriptor:SLIT-ROBO Rho GTPase-activating protein 2, SULFATE ION
Authors:Opatowsky, Y., Guez-Hadad, J.
Deposit date:2014-11-16
Release date:2015-11-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.
Structure, 23, 2015
4RUG
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CYRSTAL STRUCTURE OF SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2 FRAGMENT
Descriptor:SLIT-ROBO Rho GTPase-activating protein 2
Authors:Opatowsky, Y., Guez-Hadad, J.
Deposit date:2014-11-19
Release date:2015-11-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.
Structure, 23, 2015
5NOI
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HUMAN ROBO2 EXTRACELLULAR DOMAINS 4-5
Descriptor:Roundabout homolog 2
Authors:Opatowsky, Y., Barak, R.
Deposit date:2017-04-12
Release date:2017-10-25
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Robo Ig4 Is a Dimerization Domain.
J. Mol. Biol., 429, 2017
3KVQ
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CRYSTAL STRUCTURE OF VEGFR2 EXTRACELLULAR DOMAIN D7
Descriptor:Vascular endothelial growth factor receptor 2
Authors:Yang, Y., Opatowsky, Y., Xie, P., Schlessinger, J.
Deposit date:2009-11-30
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Proc.Natl.Acad.Sci.USA, 107, 2010
2E9W
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF KIT IN COMPLEX WITH STEM CELL FACTOR (SCF)
Descriptor:Mast/stem cell growth factor receptor, Kit ligand, N-ACETYL-D-GLUCOSAMINE
Authors:Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., Schlessinger, J.
Deposit date:2007-01-27
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
2EC8
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CRYSTAL STRUCTURE OF THE EXCTRACELLULAR DOMAIN OF THE RECEPTOR TYROSINE KINASE, KIT
Descriptor:Mast/stem cell growth factor receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., Schlessinger, J.
Deposit date:2007-02-11
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
4HLJ
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AXON GUIDANCE RECEPTOR
Descriptor:Roundabout homolog 1, PENTAETHYLENE GLYCOL
Authors:Barak, R., Opatowsky, Y.
Deposit date:2012-10-17
Release date:2013-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Axon Guidance Receptor
To be Published
4OMB
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PHOSPHATE BINDING PROTEIN
Descriptor:Phosphate binding protein, PHOSPHATE ION, PLATINUM (II) ION
Authors:Neznansky, A., Opatowsky, Y.
Deposit date:2014-01-27
Release date:2014-12-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Pseudomonas aeruginosa phosphate transport protein PstS plays a phosphate-independent role in biofilm formation.
Faseb J., 28, 2014
5I6J
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CRYSTAL STRUCTURE OF SRGAP2 F-BARX
Descriptor:SLIT-ROBO Rho GTPase-activating protein 2
Authors:Sporny, M., Guez-Haddad, J., Isupov, M.N., Opatowsky, Y.
Deposit date:2016-02-16
Release date:2017-03-08
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural History of Human SRGAP2 Proteins.
Mol. Biol. Evol., 34, 2017
5I6R
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CRYSTAL STRUCTURE OF SRGAP2 F-BARX WT FORM-1
Descriptor:SLIT-ROBO Rho GTPase-activating protein 2, D-MALATE, ACETATE ION, ...
Authors:Sporny, M., Guez-Haddad, J., Isupov, M.N., Opatowsky, Y.
Deposit date:2016-02-16
Release date:2017-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
5I7D
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CRYSTAL STRUCTURE OF SRGAP2 F-BARX WT FORM-2
Descriptor:SLIT-ROBO Rho GTPase-activating protein 2
Authors:Sporny, M., Guez-Haddad, J., Isupov, M.N., Opatowsky, Y.
Deposit date:2016-02-17
Release date:2017-08-30
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
6I9S
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HROBO2 EXTRACELLULAR DOMAINS 2-3
Descriptor:Roundabout homolog 2, SODIUM ION
Authors:Barak, R., Isupov, N.M., Opatowsky, Y.
Deposit date:2018-11-25
Release date:2019-03-13
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019
6IAA
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HROBO2 ECTODOMAIN
Descriptor:Roundabout homolog 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Barak, R., Isupov, N.M., Opatowsky, Y.
Deposit date:2018-11-26
Release date:2019-03-13
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019
4PGZ
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STRUCTURAL BASIS OF KIT ACTIVATION BY ONCOGENIC MUTATIONS IN THE EXTRACELLULAR REGION REVEALS A ZIPPER-LIKE MECHANISM FOR LIGAND-DEPENDENT OR ONCOGENIC RECEPTOR TYROSINE KINASE ACTIVATION
Descriptor:Mast/stem cell growth factor receptor Kit, N-ACETYL-D-GLUCOSAMINE, COBALT (II) ION
Authors:Reshetnyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.
Deposit date:2014-05-03
Release date:2015-03-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015