7ANW

hSARM1 NAD+ complex

Summary for 7ANW

Entry DOI	10.2210/pdb7anw/pdb
EMDB information	11187 11834
Descriptor	NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (2 entities in total)
Functional Keywords	nadase, arm domain, sam domain, tir domain, apoptosis
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	644027.90
Authors	Sporny, M.,Guez-Haddad, J.,Khazma, T.,Yaron, A.,Mim, C.,Isupov, M.N.,Zalk, R.,Dessau, M.,Hons, M.,Opatowsky, Y. (deposition date: 2020-10-13, release date: 2020-11-11, Last modification date: 2020-12-09)
Primary citation	Sporny, M.,Guez-Haddad, J.,Khazma, T.,Yaron, A.,Dessau, M.,Shkolnisky, Y.,Mim, C.,Isupov, M.N.,Zalk, R.,Hons, M.,Opatowsky, Y. Structural basis for SARM1 inhibition and activation under energetic stress. Elife, 9:-, 2020 Cited by PubMed: 33185189 DOI: 10.7554/eLife.62021 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.68 Å)

Structure validation