6ZFX

hSARM1 GraFix-ed

Summary for 6ZFX

Entry DOI	10.2210/pdb6zfx/pdb
EMDB information	11187
Descriptor	NAD(+) hydrolase SARM1, (~{E})-4-methylnon-4-enedial (2 entities in total)
Functional Keywords	nadase, arm domain, sam domain, tir domain, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	642461.79
Authors	Sporny, M.,Guez-Haddad, J.,Khazma, T.,Yaron, A.,Dessau, M.,Mim, C.,Isupov, M.N.,Zalk, R.,Hons, M.,Opatowsky, Y. (deposition date: 2020-06-18, release date: 2020-11-18, Last modification date: 2022-11-09)
Primary citation	Sporny, M.,Guez-Haddad, J.,Khazma, T.,Yaron, A.,Dessau, M.,Shkolnisky, Y.,Mim, C.,Isupov, M.N.,Zalk, R.,Hons, M.,Opatowsky, Y. Structural basis for SARM1 inhibition and activation under energetic stress. Elife, 9:-, 2020 Cited by PubMed: 33185189 DOI: 10.7554/eLife.62021 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.88 Å)

Structure validation