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4EL6
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CRYSTAL STRUCTURE OF IPSE/ALPHA-1 FROM SCHISTOSOMA MANSONI EGGS
Descriptor:IL-4-inducing protein
Authors:Mayerhofer, H., Meyer, H., Tripsianes, K., Barths, D., Blindow, S., Bade, S., Madl, T., Frey, A., Haas, H., Sattler, M., Schramm, G., Mueller-Dieckmann, J.
Deposit date:2012-04-10
Release date:2013-04-10
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structure and functional analysis of IPSE/alpha-1, an IL-4-inducing factor secreted from Schistosoma mansoni eggs, reveals an IgE-binding crystallin fold
To be Published
5NHY
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BAY-707 IN COMPLEX WITH MTH1
Descriptor:7,8-dihydro-8-oxoguanine triphosphatase, ~{N}-ethyl-4-[(3~{S})-3-methylmorpholin-4-yl]-1~{H}-pyrrolo[2,3-b]pyridine-2-carboxamide, SULFATE ION, ...
Authors:Ellermann, M., Eheim, A., Giese, A., Bunse, S., Nowak-Reppel, K., Neuhaus, R., Weiske, J., Quanz, M., Glasauer, A., Meyer, H., Queisser, N., Irlbacher, H., Bader, B., Rahm, F., Viklund, J., Andersson, M., Ericsson, U., Ginman, T., Forsblom, R., Lindstrom, J., Silvander, C., Tresaugues, L., Gorjanacz, M.
Deposit date:2017-03-22
Release date:2017-07-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
ACS Chem. Biol., 12, 2017
1ZSL
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FACTOR XI COMPLEXED WITH A PYRIMIDINONE INHIBITOR
Descriptor:Coagulation factor XI, 2-(2-(3,4-DICHLOROPHENYL)-5-(ISOPROPYLAMINO)-6-OXOPYRIMIDIN-1(6H)-YL)-N-((S)-1-OXO-1-(THIAZOL-2-YL)-5-GUANIDINOPENTAN-2-YL)ACETAMIDE
Authors:Nagafuji, P., Jin, L., Rynkiewicz, M., Quinn, J., Bibbins, F., Meyers, H., Babine, R., Strickler, J., Abdel-Meguid, S.
Deposit date:2005-05-24
Release date:2006-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Pyrimidinone Inhibitors of a Thrombolytic Protease
To be Published
1ZTJ
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH 2-(5-BENZYLAMINO-2-METHYLSULFANYL-6-OXO-6H-PYRIMIDIN-1-YL)-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-ACETAMIDE
Descriptor:Coagulation factor XI, SULFATE ION, BICARBONATE ION, ...
Authors:Nagafuji, P., Jin, L., Rynkiewicz, M., Quinn, J., Bibbins, F., Meyers, H., Babine, R.E., Strickler, J.E., Abdel-Meguid, S.S.
Deposit date:2005-05-27
Release date:2006-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Pyrimidinone Inhibitors of a Thrombolytic Protease
To be Published
1ZTK
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH 2-(5-AMINO-6-OXO-2-M-TOLYL-6H-PYRIMIDIN-1-YL)-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-ACETAMIDE
Descriptor:Coagulation factor XI, SULFATE ION, 2-(5-AMINO-6-OXO-2-M-TOLYL-6H-PYRIMIDIN-1-YL)-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-ACETAMIDE
Authors:Nagafuji, P., Jin, L., Rynkiewicz, M., Quinn, J., Bibbins, F., Meyers, H., Babine, R.E., Strickler, J.E., Abdel-Meguid, S.S.
Deposit date:2005-05-27
Release date:2006-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pyrimidinone Inhibitors of a Thrombolytic Protease
To be Published
1ZTL
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-2-{6-OXO-5-[(QUINOLIN-8-YLMETHYL)-AMINO]-2-M-TOLYL-6H-PYRIMIDIN-1-YL}-ACETAMIDE
Descriptor:Coagulation factor XI, SULFATE ION, N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-2-{6-OXO-5-[(QUINOLIN-8-YLMETHYL)-AMINO]-2-M-TOLYL-6H-PYRIMIDIN-1-YL}-ACETAMIDE
Authors:Nagafuji, P., Jin, L., Rynkiewicz, M., Quinn, J., Bibbins, F., Meyers, H., Babine, R., Strickler, J.E., Abdel-Meguid, S.S.
Deposit date:2005-05-27
Release date:2006-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Pyrimidinone Inhibitors of a Thrombolytic Protease
To be Published
5BPK
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VARYING BINDING MODES OF INHIBITORS AND STRUCTURAL DIFFERENCES IN THE BINDING POCKETS OF DIFFERENT GAMMA-GLUTAMYLTRANSPEPTIDASES
Descriptor:Gamma-glutamyltranspeptidase (Ggt), 1,2-ETHANEDIOL, (2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
Authors:Bolz, C., Bach, N.C., Meyer, H., Mueller, G., Dawidowski, M., Popowicz, G., Sieber, S.A., Skerra, A., Gerhard, M.
Deposit date:2015-05-28
Release date:2016-05-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
To Be Published
2XL1
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STRUCTURAL BASIS OF TRANSLATIONAL STALLING BY HUMAN CYTOMEGALOVIRUS (HCMV) AND FUNGAL ARGININE ATTENUATOR PEPTIDE (AAP)
Descriptor:ARGININE ATTENUATOR PEPTIDE
Authors:Meyer, N.H., Sattler, M.
Deposit date:2010-07-15
Release date:2010-10-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide.
Mol.Cell, 40, 2010
1E32
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STRUCTURE OF THE N-TERMINAL DOMAIN AND THE D1 AAA DOMAIN OF MEMBRANE FUSION ATPASE P97
Descriptor:P97, ADENOSINE-5'-DIPHOSPHATE
Authors:Zhang, X., Shaw, A., Bates, P.A., Gorman, M.A., Kondo, H., Dokurno, P., Leonard M, G., Sternberg, J.E., Freemont, P.S.
Deposit date:2000-06-05
Release date:2001-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Aaa ATPase P97
Mol.Cell, 6, 2000
1LDM
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REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE
Descriptor:M4 LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID
Authors:Griffith, J.P., Rossmann, M.G.
Deposit date:1987-11-25
Release date:1989-07-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.
J.Mol.Biol., 198, 1987
3LDH
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A COMPARISON OF THE STRUCTURES OF APO DOGFISH M4 LACTATE DEHYDROGENASE AND ITS TERNARY COMPLEXES
Descriptor:LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID
Authors:White, J.L., Hackert, M.L., Buehner, M., Adams, M.J., Ford, G.C., Lentzjunior, P.J., Smiley, I.E., Steindel, S.J., Rossmann, M.G.
Deposit date:1974-06-06
Release date:1977-04-29
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes.
J.Mol.Biol., 102, 1976
6LDH
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REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE
Descriptor:M4 APO-LACTATE DEHYDROGENASE, SULFATE ION
Authors:Abad-Zapatero, C., Rossmann, M.G.
Deposit date:1987-11-25
Release date:1989-07-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.
J.Mol.Biol., 198, 1987
8LDH
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REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE
Descriptor:M4 APO-LACTATE DEHYDROGENASE, CITRIC ACID
Authors:Abad-Zapatero, C., Rossmann, M.G.
Deposit date:1988-01-04
Release date:1989-07-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.
J.Mol.Biol., 198, 1987