6QU7

Crystal structure of human DHODH in complex with BAY 2402234

Summary for 6QU7

• Entry DOI: 10.2210/pdb6qu7/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, OROTIC ACID, FLAVIN MONONUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: dhodh, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41286.92

Authors

Friberg, A.,Gradl, S. (deposition date: 2019-02-26, release date: 2019-06-05, Last modification date: 2019-10-16)

• Primary citation: Christian, S.,Merz, C.,Evans, L.,Gradl, S.,Seidel, H.,Friberg, A.,Eheim, A.,Lejeune, P.,Brzezinka, K.,Zimmermann, K.,Ferrara, S.,Meyer, H.,Lesche, R.,Stoeckigt, D.,Bauser, M.,Haegebarth, A.,Sykes, D.B.,Scadden, D.T.,Losman, J.A.,Janzer, A.; The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.; Leukemia, 33:2403-2415, 2019; PubMed: 30940908; DOI: 10.1038/s41375-019-0461-5

Experimental method

X-RAY DIFFRACTION (1.52 Å)