1ZSL

Factor XI complexed with a pyrimidinone inhibitor

Summary for 1ZSL

• Entry DOI: 10.2210/pdb1zsl/pdb
• Related: 1ZHR
• Descriptor: Coagulation factor XI, 2-(2-(3,4-DICHLOROPHENYL)-5-(ISOPROPYLAMINO)-6-OXOPYRIMIDIN-1(6H)-YL)-N-((S)-1-OXO-1-(THIAZOL-2-YL)-5-GUANIDINOPENTAN-2-YL)ACETAMIDE (3 entities in total)
• Functional Keywords: serine protease, coagulation, covalent complex, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P03951
• Total number of polymer chains: 1
• Total formula weight: 27377.90

Authors

Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.,Abdel-Meguid, S. (deposition date: 2005-05-24, release date: 2006-05-09, Last modification date: 2023-08-23)

• Primary citation: Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.,Abdel-Meguid, S.; Pyrimidinone Inhibitors of a Thrombolytic Protease; To be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)